2024
International reproducibility study of thymic epithelial tumors staging: pT stage is an issue. proposals for improvement. A RYTHMIC/ITMIG study
Molina T, Roden A, Szolkowska M, Shimizu S, Moreira A, Chalabreysse L, Besse B, de Montpréville V, Marom E, Detterbeck F, Girard N, Nicholson A, Marx A. International reproducibility study of thymic epithelial tumors staging: pT stage is an issue. proposals for improvement. A RYTHMIC/ITMIG study. Lung Cancer 2024, 189: 107479. PMID: 38306885, DOI: 10.1016/j.lungcan.2024.107479.Peer-Reviewed Original ResearchThymic epithelial tumorsInternational Thymic Malignancy Interest GroupPT stageTNM classificationMediastinal pleuraInternational panel of pathologistsPathological tumor stagePanel of pathologistsCohort of casesEpithelial tumorsTumor stageTNM systemInterobserver reproducibilityAncillary testsExpert pathologistsPleuraValidation seriesTNMPathologistsLungPericardiumInternational panelPotential interventionsInternational levelTumor
2021
The 2021 WHO Classification of Tumors of the Thymus and Mediastinum: What Is New in Thymic Epithelial, Germ Cell, and Mesenchymal Tumors?
Marx A, Chan JKC, Chalabreysse L, Dacic S, Detterbeck F, French CA, Hornick JL, Inagaki H, Jain D, Lazar AJ, Marino M, Marom EM, Moreira AL, Nicholson AG, Noguchi M, Nonaka D, Papotti MG, Porubsky S, Sholl LM, Tateyama H, Thomas de Montpréville V, Travis WD, Rajan A, Roden AC, Ströbel P. The 2021 WHO Classification of Tumors of the Thymus and Mediastinum: What Is New in Thymic Epithelial, Germ Cell, and Mesenchymal Tumors? Journal Of Thoracic Oncology 2021, 17: 200-213. PMID: 34695605, DOI: 10.1016/j.jtho.2021.10.010.Peer-Reviewed Original ResearchConceptsThymic epithelial tumorsGerm cell tumorsCell tumorsMesenchymal neoplasmsWHO classificationEpithelial tumorsMediastinal germ cell tumorsLow tumor mutational burdenTumor mutational burdenNew tumor entityClear cell carcinomaPositron emission tomographyClassification of tumorsThymic EpithelialThymic carcinomaFifth editionB3 thymomaTargetable mutationsCell carcinomaMesenchymal tumorsMetaplastic thymomaImmunohistochemical characterizationClinical informationMutational burdenDiagnostic advances
2019
A Recurrence Predictive Model for Thymic Tumors and Its Implication for Postoperative Management: a Chinese Alliance for Research in Thymomas Database Study
Liu H, Gu Z, Qiu B, Detterbeck FC, Roden AC, Ruffini E, Okumura M, Girard N, Xiang Y, Liu Y, Du Z, Hao Y, Fu J, Zhang P, Pang L, Chen K, Wang Y, Yu Z, Mao T, Fang W, Group A. A Recurrence Predictive Model for Thymic Tumors and Its Implication for Postoperative Management: a Chinese Alliance for Research in Thymomas Database Study. Journal Of Thoracic Oncology 2019, 15: 448-456. PMID: 31726106, DOI: 10.1016/j.jtho.2019.10.018.Peer-Reviewed Original ResearchConceptsHigh-risk patientsAdjuvant therapyPostoperative yearThymic carcinomaComplete resectionPostoperative managementNeuroendocrine tumorsBootstrap-corrected C-indexChinese AlliancePostoperative adjuvant therapyIndependent predictive factorsLow-risk patientsMultivariate Cox regressionOverall survival rateAppropriate postoperative managementThymic epithelial tumorsHigh-risk groupLow-risk groupIIIA tumorsLocoregional recurrenceDisease recurrenceB3 thymomaHistologic typeNomogram modelT stage
2018
Eighth Edition Staging of Thoracic Malignancies: Implications for the Reporting Pathologist
Nicholson AG, Tsao MS, Travis WD, Patil DT, Galateau-Salle F, Marino M, Dacic S, Beasley MB, Butnor KJ, Yatabe Y, Pass HI, Rusch VW, Detterbeck FC, Asamura H, Rice TW, Rami-Porta R. Eighth Edition Staging of Thoracic Malignancies: Implications for the Reporting Pathologist. Archives Of Pathology & Laboratory Medicine 2018, 142: 645-661. PMID: 29480761, DOI: 10.5858/arpa.2017-0245-ra.Peer-Reviewed Original ResearchConceptsAmerican Joint CommitteeInternational Cancer ControlThoracic malignanciesReporting pathologistCancer controlJoint CommitteeWorldwide Esophageal Cancer CollaborationInternational Thymic Malignancy Interest GroupUS National Cancer DatabaseInternational Mesothelioma Interest GroupEighth edition stagingNational Cancer DatabaseThymic epithelial tumorsPrognostic Factors CommitteeEdition stagingStaging ManualEsophagogastric junctionThoracic cancerLung cancerCancer DatabaseRespective tumorsEpithelial tumorsEpithelial cancersCancerStaging
2017
Paraneoplastic Syndromes and Thymic Malignancies: An Examination of the International Thymic Malignancy Interest Group Retrospective Database
Padda SK, Yao X, Antonicelli A, Riess JW, Shang Y, Shrager JB, Korst R, Detterbeck F, Huang J, Burt BM, Wakelee HA, Badve SS. Paraneoplastic Syndromes and Thymic Malignancies: An Examination of the International Thymic Malignancy Interest Group Retrospective Database. Journal Of Thoracic Oncology 2017, 13: 436-446. PMID: 29191778, PMCID: PMC5983900, DOI: 10.1016/j.jtho.2017.11.118.Peer-Reviewed Original ResearchConceptsThymic epithelial tumorsIndependent prognostic factorOverall survivalPrognostic factorsPrognostic roleRetrospective databaseCox proportional hazards modelKaplan-Meier methodRecurrence-free survivalProportional hazards modelParaneoplastic syndromeCumulative incidenceResection statusTotal thymectomyMyasthenia gravisThymic malignanciesHistologic typeSyndrome statusFemale sexTreatment characteristicsEpithelial tumorsHazards modelLower CIRSyndromeMultivariate analysisPositron Emission Tomography in Thymic Tumors: Analysis Using a Prospective Research Database
Korst RJ, Fernando S, Catlin AC, Rutledge JR, Girard N, Huang J, Detterbeck F, Database C. Positron Emission Tomography in Thymic Tumors: Analysis Using a Prospective Research Database. The Annals Of Thoracic Surgery 2017, 104: 1815-1820. PMID: 29033016, PMCID: PMC5785101, DOI: 10.1016/j.athoracsur.2017.06.053.Peer-Reviewed Original ResearchConceptsPositron emission tomographyInternational Thymic Malignancy Interest GroupHistologic typeThymic malignanciesPretreatment workupPathologic stageEmission tomographyProspective databaseThymic tumorsTumor stageMaximum standardized uptake valueProspective research databaseHistologic tumor typeThymic epithelial tumorsStandardized uptake valueCharacteristic curveAnalysis of receiverClinicopathologic featuresRare tumorEpithelial tumorsLarge cohortResearch DatabaseUptake valueTumor typesPatients
2016
Dataset for reporting of thymic epithelial tumours: recommendations from the International Collaboration on Cancer Reporting (ICCR)
Nicholson AG, Detterbeck F, Marx A, Roden AC, Marchevsky AM, Mukai K, Chen G, Marino M, Bakker M, Yang W, Judge M, Hirschowitz L. Dataset for reporting of thymic epithelial tumours: recommendations from the International Collaboration on Cancer Reporting (ICCR). Histopathology 2016, 70: 522-538. PMID: 27735079, DOI: 10.1111/his.13099.Peer-Reviewed Original ResearchComparison of outcomes between neuroendocrine thymic tumours and other subtypes of thymic carcinomas: a joint analysis of the European Society of Thoracic Surgeons and the International Thymic Malignancy Interest Group†
Filosso PL, Yao X, Ruffini E, Ahmad U, Antonicelli A, Huang J, Guerrera F, Venuta F, van Raemdonck D, Travis W, Lucchi M, Rimner A, Thomas P, Weder W, Rocco G, Detterbeck F, Korst R. Comparison of outcomes between neuroendocrine thymic tumours and other subtypes of thymic carcinomas: a joint analysis of the European Society of Thoracic Surgeons and the International Thymic Malignancy Interest Group†. European Journal Of Cardio-Thoracic Surgery 2016, 50: 766-771. PMID: 27032473, PMCID: PMC6279171, DOI: 10.1093/ejcts/ezw107.Peer-Reviewed Original ResearchConceptsNeuroendocrine thymic tumoursRecurrence-free survivalThymic carcinomaOverall survivalSurvival rateThymic tumorsThoracic surgeonsFive-year recurrence-free survivalWorld Health Organization histological classificationRetrospective multicentre cohort studyInternational Thymic Malignancy Interest GroupMedian overall survivalMulticentre cohort studyEuropean SocietyKaplan-Meier methodThymic epithelial tumorsLarge clinical seriesLog-rank testComparison of outcomesGroup of tumorsR0 resectionCohort studyPrognostic factorsNET patientsTC patients
2015
The 2015 World Health Organization Classification of Tumors of the Thymus: Continuity and Changes
Marx A, Chan JK, Coindre JM, Detterbeck F, Girard N, Harris NL, Jaffe ES, Kurrer MO, Marom EM, Moreira AL, Mukai K, Orazi A, Ströbel P. The 2015 World Health Organization Classification of Tumors of the Thymus: Continuity and Changes. Journal Of Thoracic Oncology 2015, 10: 1383-1395. PMID: 26295375, PMCID: PMC4581965, DOI: 10.1097/jto.0000000000000654.Peer-Reviewed Original ResearchConceptsWorld Health Organization classificationThymic epithelial tumorsOrganization classificationEpithelial tumorsThymic squamous cell carcinomaPositron emission tomography/Squamous cell carcinomaGerm cell tumorsNew tumor entityEmission tomography/Soft tissue tumorsClassification of tumorsDendritic cellsMediastinal lymphomaThymic tumorsCell carcinomaCell tumorsThoracic surgeryTomography/Therapeutic decisionsThymus sectionsMyeloid neoplasmsTumor entitiesDiagnostic criteriaClinical relevance
2014
The ITMIG/IASLC Thymic Epithelial Tumors Staging Project: A Proposed Lymph Node Map for Thymic Epithelial Tumors in the Forthcoming 8th Edition of the TNM Classification of Malignant Tumors
Bhora FY, Chen DJ, Detterbeck FC, Asamura H, Falkson C, Filosso PL, Giaccone G, Huang J, Kim J, Kondo K, Lucchi M, Marino M, Marom EM, Nicholson AG, Okumura M, Ruffini E, Van Schil P, Committee††† O, Boards‡‡‡ A. The ITMIG/IASLC Thymic Epithelial Tumors Staging Project: A Proposed Lymph Node Map for Thymic Epithelial Tumors in the Forthcoming 8th Edition of the TNM Classification of Malignant Tumors. Journal Of Thoracic Oncology 2014, 9: s88-s96. PMID: 25396317, DOI: 10.1097/jto.0000000000000293.Peer-Reviewed Original ResearchConceptsThymic malignanciesNodal diseaseNeck surgeryNode mapInternational Thymic Malignancy Interest GroupLymph node dissectionThymic epithelial tumorsLymph node mapPrior classification systemsPrognostic Factors CommitteeNode dissectionNodal involvementNode stagingTNM classificationLung cancerMalignant tumorsEpithelial tumorsOtolaryngology-HeadLymphatic drainageIASLC stagingAmerican AcademyMalignancyStagingAnatomical studyDiseaseA Practical Guide from the International Thymic Malignancy Interest Group (ITMIG) Regarding the Radiographic Assessment of Treatment Response of Thymic Epithelial Tumors Using Modified RECIST Criteria
Benveniste MF, Korst RJ, Rajan A, Detterbeck FC, Marom EM. A Practical Guide from the International Thymic Malignancy Interest Group (ITMIG) Regarding the Radiographic Assessment of Treatment Response of Thymic Epithelial Tumors Using Modified RECIST Criteria. Journal Of Thoracic Oncology 2014, 9: s119-s124. PMID: 25396308, DOI: 10.1097/jto.0000000000000296.Peer-Reviewed Original ResearchConceptsInternational Thymic Malignancy Interest GroupTumor measurementsProgression-free survivalThymic epithelial tumorsStandard outcome measuresMulti-institutional studyAccurate tumor measurementsRECIST criteriaTumor responseClinical trialsRadiographic assessmentTreatment responseEpithelial tumorsOutcome measuresResponse rateInterobserver variabilityThymomaPractical guideInterest group recommendationsChemotherapyPleuraTumorsITMIG Consensus Statement on the Use of the WHO Histological Classification of Thymoma and Thymic Carcinoma: Refined Definitions, Histological Criteria, and Reporting
Marx A, Ströbel P, Badve SS, Chalabreysse L, Chan JK, Chen G, de Leval L, Detterbeck F, Girard N, Huang J, Kurrer MO, Lauriola L, Marino M, Matsuno Y, Molina TJ, Mukai K, Nicholson AG, Nonaka D, Rieker R, Rosai J, Ruffini E, Travis WD. ITMIG Consensus Statement on the Use of the WHO Histological Classification of Thymoma and Thymic Carcinoma: Refined Definitions, Histological Criteria, and Reporting. Journal Of Thoracic Oncology 2014, 9: 596-611. PMID: 24722150, DOI: 10.1097/jto.0000000000000154.Peer-Reviewed Original ResearchConceptsThymic carcinomaThymic epithelial tumorsB3 thymomaEpithelial tumorsInternational Thymic Malignancy Interest GroupWorld Health Organization classificationPoor interobserver reproducibilityHistological patternOrganization classificationConsensus statementHistological classificationHistological criteriaThymoma subtypesThymomaAtypical typeGrading systemInterobserver reproducibilityTumorsCarcinomaReproducibility studyRefined criteriaMorphological overlapSubtypesVariable proportions
2013
Historical perspectives: The evolution of the thymic epithelial tumors staging system
Filosso PL, Ruffini E, Lausi PO, Lucchi M, Oliaro A, Detterbeck F. Historical perspectives: The evolution of the thymic epithelial tumors staging system. Lung Cancer 2013, 83: 126-132. PMID: 24377980, DOI: 10.1016/j.lungcan.2013.09.013.Peer-Reviewed Original Research