2012
Use of N‐acetylcysteine during liver procurement: A prospective randomized controlled study
D'Amico F, Vitale A, Piovan D, Bertacco A, Morales R, Frigo A, Bassi D, Bonsignore P, Gringeri E, Valmasoni M, Garbo G, Lodo E, D'Amico FE, Scopelliti M, Carraro A, Gambato M, Brolese A, Zanus G, Neri D, Cillo U. Use of N‐acetylcysteine during liver procurement: A prospective randomized controlled study. Liver Transplantation 2012, 19: 135-144. PMID: 22859317, DOI: 10.1002/lt.23527.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcysteineAdolescentAdultAgedAntioxidantsChi-Square DistributionFemaleGraft SurvivalHumansInfusions, IntravenousItalyKaplan-Meier EstimateLiver TransplantationMaleMiddle AgedPortal VeinPrimary Graft DysfunctionProportional Hazards ModelsProspective StudiesSingle-Blind MethodTime FactorsTissue and Organ HarvestingTreatment OutcomeYoung AdultConceptsGraft survivalLiver transplantationNAC groupLiver procurementN-acetylcysteineControl groupSuboptimal graftsEffect of NACNAC protocolIschemia/reperfusion damageFirst liver transplantationEarly graft functionGraft survival ratesChronic liver diseaseSingle-blinded procedureGraft functionLT outcomesPostoperative complicationsPrimary endpointCox analysisNAC infusionRandomized studyLiver diseaseAdult candidatesPrimary dysfunction
2007
Cross-talk between PDGF and S1P signalling elucidates the inhibitory effect and potential antifibrotic action of the immunomodulator FTY720 in activated HSC-cultures
Brunati A, Tibaldi E, Carraro A, Gringeri E, D’Amico F, Toninello A, Massimino M, Pagano M, Nalesso G, Cillo U. Cross-talk between PDGF and S1P signalling elucidates the inhibitory effect and potential antifibrotic action of the immunomodulator FTY720 in activated HSC-cultures. Biochimica Et Biophysica Acta 2007, 1783: 347-359. PMID: 18157950, DOI: 10.1016/j.bbamcr.2007.11.008.Peer-Reviewed Original ResearchConceptsPlatelet-derived growth factorHepatic stellate cellsTyrosine phosphorylation of PDGF receptorsSignaling pathwayPlatelet-derived growth factor stimulationCross-talkPlatelet-derived growth factor signaling pathwaysPhosphorylation of PDGF receptorS1P signalingStimulation of chemotaxisPlasma membranePhosphorylated formSphingosine-1-phosphateEffect of FTY720Activation of hepatic stellate cellsReceptor-independent wayFTY720 phosphorylationDevelopment of hepatic fibrosisS1P signaling pathwayPDGF receptorsCell typesCell proliferationPhosphorylationAntifibrotic actionMechanism of action
2005
Role of blood AFP mRNA and tumor grade in the preoperative prognostic evaluation of patients with hepatocellular carcinoma
Cillo U, Vitale A, Navaglia F, Basso D, Montin U, Bassanello M, D'Amico F, Ciarleglio F, Brolese A, Zanus G, De Pascale V, Plebani M, D'Amico D. Role of blood AFP mRNA and tumor grade in the preoperative prognostic evaluation of patients with hepatocellular carcinoma. World Journal Of Gastroenterology 2005, 11: 6920-6925. PMID: 16437593, PMCID: PMC4717031, DOI: 10.3748/wjg.v11.i44.6920.Peer-Reviewed Original ResearchConceptsTumor gradeHepatocellular carcinomaRadical therapyAFP mRNASurgical therapyMRNA statusPrognostic evaluation of HCC patientsAssessment of tumor gradePrognostic evaluation of patientsDiagnosis of hepatocellular carcinomaNodule sizeDetermination of tumor gradeEvaluation of HCC patientsPreoperative tumor gradeMedian follow-upPercutaneous ablative proceduresTumor-related variablesSignificant survival predictorsPotential prognostic roleCohort of patientsEvaluation of patientsSignificant prognosticatorsPrognostic rolePercutaneous biopsyPerformance status