Cross-talk between PDGF and S1P signalling elucidates the inhibitory effect and potential antifibrotic action of the immunomodulator FTY720 in activated HSC-cultures
Brunati A, Tibaldi E, Carraro A, Gringeri E, D’Amico F, Toninello A, Massimino M, Pagano M, Nalesso G, Cillo U. Cross-talk between PDGF and S1P signalling elucidates the inhibitory effect and potential antifibrotic action of the immunomodulator FTY720 in activated HSC-cultures. Biochimica Et Biophysica Acta 2007, 1783: 347-359. PMID: 18157950, DOI: 10.1016/j.bbamcr.2007.11.008.Peer-Reviewed Original ResearchConceptsPlatelet-derived growth factorHepatic stellate cellsTyrosine phosphorylation of PDGF receptorsSignaling pathwayPlatelet-derived growth factor stimulationCross-talkPlatelet-derived growth factor signaling pathwaysPhosphorylation of PDGF receptorS1P signalingStimulation of chemotaxisPlasma membranePhosphorylated formSphingosine-1-phosphateEffect of FTY720Activation of hepatic stellate cellsReceptor-independent wayFTY720 phosphorylationDevelopment of hepatic fibrosisS1P signaling pathwayPDGF receptorsCell typesCell proliferationPhosphorylationAntifibrotic actionMechanism of actionA New Experimental Model of Isolated Perfused Pig Liver to Support Acute Hepatic Failure
Carraro A, Gringeri E, Calabrese F, Violi P, Brolese A, Zanus G, Boccagni P, Valente M, Bassi D, D’Amico F, D’Amico D, Cillo U. A New Experimental Model of Isolated Perfused Pig Liver to Support Acute Hepatic Failure. Transplantation Proceedings 2007, 39: 2028-2030. PMID: 17692683, DOI: 10.1016/j.transproceed.2007.05.070.Peer-Reviewed Original ResearchConceptsPerfused liver modelIsolated porcine liverLiver transplantationLiver failureAwaiting transplantationOrgan procurement ratesHepatic functionEffective treatmentEx vivo perfused liver modelPortal bloodHemodynamic homeostasisIsolated liverPerfused pig liverLiverLiver supportRecipient pigsTransplantationPatientsIsolated perfused pig liverLiver modelProcurement ratesMetabolic capacity