2024
The Italian experience on liver transplantation for unresectable peri-hilar cholangiocarcinoma: a national survey and future perspectives
Gringeri E, Furlanetto A, Billato I, Cescon M, De Carlis L, Mazzaferro V, Romagnoli R, De Simone P, Vivarelli M, Di Benedetto F, Ravaioli M, Lauterio A, Sposito C, Patrono D, Ghinolfi D, Moccheggiani F, Di Sandro S, D’Amico F, Lanari J, Gambato M, Trapani S, Bergamo F, Cardillo M, Burra P, Cillo U. The Italian experience on liver transplantation for unresectable peri-hilar cholangiocarcinoma: a national survey and future perspectives. Updates In Surgery 2024, 1-9. PMID: 39210194, DOI: 10.1007/s13304-024-01889-1.Peer-Reviewed Original ResearchNeoadjuvant radio-chemotherapyPerihilar cholangiocarcinomaLiver transplantationGroup 1Radio-chemotherapyGroup 2Standard of care chemotherapyRisk of cancer-related deathInclusion criteriaPeri-hilar cholangiocarcinomaRecurrence-free survivalResults of LTRisk regression analysisCancer-related deathsLiver transplant centersMayo protocolNeoadjuvant regimenNeoadjuvant treatmentCare chemotherapyOverall survivalProspective studyMayo ClinicHazard ratioTransplant centersIneffective treatmentAdvocating for a “shift-to-left” in transplant oncology: left grafts, RAPID and dual graft
Cillo U, Furlanetto A, Gringeri E, Bertacco A, Marchini A, Rosso E, Bassi D, D’Amico F, Line P. Advocating for a “shift-to-left” in transplant oncology: left grafts, RAPID and dual graft. Updates In Surgery 2024, 1-14. PMID: 39120859, DOI: 10.1007/s13304-024-01919-y.Peer-Reviewed Original ResearchLiving donor liver transplantationRisk of small-for-size syndromeSmall-for-size syndromeDual-graft living donor liver transplantationHigh-volume transplant centerDonor liver transplantationDonor-recipient matchingShortage of graftsLeft-lobeLiver transplantationRight-lobeOncological indicationsTransplant oncologyDonor hepatectomyDual graftsTransplant centersHigh riskLeft graftGraftFull-left/Full-right Liver Splitting With Middle Hepatic Vein and Caval Partition During Dual Hypothermic Oxygenated Machine Perfusion
Cillo U, Lauterio A, Furlanetto A, Canitano N, Polacco M, Buscemi V, De Carlis R, Boetto R, D’Amico F, Bassi D, De Carlis L, Gringeri E. Full-left/Full-right Liver Splitting With Middle Hepatic Vein and Caval Partition During Dual Hypothermic Oxygenated Machine Perfusion. Transplantation 2024, 108: 1417-1421. PMID: 38755751, DOI: 10.1097/tp.0000000000005039.Peer-Reviewed Original ResearchMiddle hepatic veinHypothermic oxygenated machine perfusionOxygenated machine perfusionHepatic veinVena cavaMachine perfusionEffects of ischemia-reperfusion injuryLiver splittingDual hypothermic oxygenated machine perfusionIschemia-reperfusion injuryProlonged cold ischemiaSplit liver transplantationEx situ splittingPediatric patientsVenous reconstructionParenchymal transectionAdult patientsLiver transplantationHepatocellular carcinomaVenous congestionRight graftCold ischemiaVenous outflowProlonged ischemiaImprove outcomesWhat Is the Role of Minimally Invasive Liver Surgery in Treating Patients with Hepatocellular Carcinoma on Cirrhosis?
Vitale A, Angelico R, Sensi B, Lai Q, Kauffmann E, Scalera I, Serenari M, Ginesini M, Romano P, Furlanetto A, D’Amico F. What Is the Role of Minimally Invasive Liver Surgery in Treating Patients with Hepatocellular Carcinoma on Cirrhosis? Cancers 2024, 16: 966. PMID: 38473327, PMCID: PMC10930835, DOI: 10.3390/cancers16050966.Peer-Reviewed Original ResearchMinimally invasive liver surgeryOpen surgeryLiver surgerySignificant cardiovascular riskTrans-arterial approachResection outcomesLaparoscopic ablationResected casesLiver transplantationTreated patientsHepatocellular carcinomaEfficacious therapyCardiovascular riskSurgeryPatientsNarrative reviewTreatment hierarchyCurative techniqueHCCResectionCarcinomaCirrhosisTransplantationTherapy
2012
Use of N‐acetylcysteine during liver procurement: A prospective randomized controlled study
D'Amico F, Vitale A, Piovan D, Bertacco A, Morales R, Frigo A, Bassi D, Bonsignore P, Gringeri E, Valmasoni M, Garbo G, Lodo E, D'Amico FE, Scopelliti M, Carraro A, Gambato M, Brolese A, Zanus G, Neri D, Cillo U. Use of N‐acetylcysteine during liver procurement: A prospective randomized controlled study. Liver Transplantation 2012, 19: 135-144. PMID: 22859317, DOI: 10.1002/lt.23527.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcysteineAdolescentAdultAgedAntioxidantsChi-Square DistributionFemaleGraft SurvivalHumansInfusions, IntravenousItalyKaplan-Meier EstimateLiver TransplantationMaleMiddle AgedPortal VeinPrimary Graft DysfunctionProportional Hazards ModelsProspective StudiesSingle-Blind MethodTime FactorsTissue and Organ HarvestingTreatment OutcomeYoung AdultConceptsGraft survivalLiver transplantationNAC groupLiver procurementN-acetylcysteineControl groupSuboptimal graftsEffect of NACNAC protocolIschemia/reperfusion damageFirst liver transplantationEarly graft functionGraft survival ratesChronic liver diseaseSingle-blinded procedureGraft functionLT outcomesPostoperative complicationsPrimary endpointCox analysisNAC infusionRandomized studyLiver diseaseAdult candidatesPrimary dysfunction
2007
A New Experimental Model of Isolated Perfused Pig Liver to Support Acute Hepatic Failure
Carraro A, Gringeri E, Calabrese F, Violi P, Brolese A, Zanus G, Boccagni P, Valente M, Bassi D, D’Amico F, D’Amico D, Cillo U. A New Experimental Model of Isolated Perfused Pig Liver to Support Acute Hepatic Failure. Transplantation Proceedings 2007, 39: 2028-2030. PMID: 17692683, DOI: 10.1016/j.transproceed.2007.05.070.Peer-Reviewed Original ResearchConceptsPerfused liver modelIsolated porcine liverLiver transplantationLiver failureAwaiting transplantationOrgan procurement ratesHepatic functionEffective treatmentEx vivo perfused liver modelPortal bloodHemodynamic homeostasisIsolated liverPerfused pig liverLiverLiver supportRecipient pigsTransplantationPatientsIsolated perfused pig liverLiver modelProcurement ratesMetabolic capacity
2003
Thermal homeostasis and liver transplantation.
D'Amico D, Vitale A, Cillo U, Boccagni P, Brolese A, Zanus G, Bassanello M, Montin U, Gringeri E, D'Amico F, Ciarleglio F, Cappuzzo G, Carraro A. Thermal homeostasis and liver transplantation. Acta BioMedica 2003, 74 Suppl 2: 30-3. PMID: 15055030.Peer-Reviewed Original ResearchConceptsGraft ischemia-reperfusion injuryGraft function recoveryPostoperative graft functionIschemia-reperfusion injuryInfluence of hypothermiaIntraoperative heat lossGraft functionLiver transplantationSevere hypothermiaCoagulation systemNormothermic oxygenated perfusionFunctional recoveryExtracorporeal circuitDonor poolAngiogenic mechanismsHypothermiaActive warmingOxygenated perfusionThermal homeostasisClinical researchGraftCardiovascular activityLiverDeleterious effectsHomeostasis