2012
Use of N‐acetylcysteine during liver procurement: A prospective randomized controlled study
D'Amico F, Vitale A, Piovan D, Bertacco A, Morales R, Frigo A, Bassi D, Bonsignore P, Gringeri E, Valmasoni M, Garbo G, Lodo E, D'Amico FE, Scopelliti M, Carraro A, Gambato M, Brolese A, Zanus G, Neri D, Cillo U. Use of N‐acetylcysteine during liver procurement: A prospective randomized controlled study. Liver Transplantation 2012, 19: 135-144. PMID: 22859317, DOI: 10.1002/lt.23527.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcysteineAdolescentAdultAgedAntioxidantsChi-Square DistributionFemaleGraft SurvivalHumansInfusions, IntravenousItalyKaplan-Meier EstimateLiver TransplantationMaleMiddle AgedPortal VeinPrimary Graft DysfunctionProportional Hazards ModelsProspective StudiesSingle-Blind MethodTime FactorsTissue and Organ HarvestingTreatment OutcomeYoung AdultConceptsGraft survivalLiver transplantationNAC groupLiver procurementN-acetylcysteineControl groupSuboptimal graftsEffect of NACNAC protocolIschemia/reperfusion damageFirst liver transplantationEarly graft functionGraft survival ratesChronic liver diseaseSingle-blinded procedureGraft functionLT outcomesPostoperative complicationsPrimary endpointCox analysisNAC infusionRandomized studyLiver diseaseAdult candidatesPrimary dysfunction
2003
Thermal homeostasis and liver transplantation.
D'Amico D, Vitale A, Cillo U, Boccagni P, Brolese A, Zanus G, Bassanello M, Montin U, Gringeri E, D'Amico F, Ciarleglio F, Cappuzzo G, Carraro A. Thermal homeostasis and liver transplantation. Acta BioMedica 2003, 74 Suppl 2: 30-3. PMID: 15055030.Peer-Reviewed Original ResearchConceptsGraft ischemia-reperfusion injuryGraft function recoveryPostoperative graft functionIschemia-reperfusion injuryInfluence of hypothermiaIntraoperative heat lossGraft functionLiver transplantationSevere hypothermiaCoagulation systemNormothermic oxygenated perfusionFunctional recoveryExtracorporeal circuitDonor poolAngiogenic mechanismsHypothermiaActive warmingOxygenated perfusionThermal homeostasisClinical researchGraftCardiovascular activityLiverDeleterious effectsHomeostasis