Daniel Jacobs, MD
Hospital ResidentAbout
Research
Publications
2025
Targeting an essential viral oncoprotein with an IL-7-enhanced mRNA vaccine induces durable immunity to Merkel cell carcinoma
Frey A, Clulo K, Fei Y, Dumit T, Scallo F, Williams J, Chang E, Perry C, Wirth L, Jacobs D, Braun D, Bosenberg M, Tran T, Clune J, Kluger H, Olino K, Ishizuka J. Targeting an essential viral oncoprotein with an IL-7-enhanced mRNA vaccine induces durable immunity to Merkel cell carcinoma. Cell Reports 2025, 44: 116359. PMID: 41042672, DOI: 10.1016/j.celrep.2025.116359.Peer-Reviewed Original ResearchMerkel cell carcinomaMRNA vaccinesCell carcinomaCD8+ T cell memoryAntigen-specific T cell expansionTumor cell expressionT cell expansionT cell memoryTumor cell survivalTumor controlMemory differentiationAntigen lossResponse durabilityMurine studiesAntigen exposureIL-7Mouse modelOptimal vaccine targetsCell expressionMRNA technologyPatient samplesMRNA therapeuticsStrong antigensTumorViral oncoproteinsHealth-Related Quality of Life Metrics in Patients With Retrograde Cricopharyngeus Dysfunction
Jacobs D, Duffy J, Lerner B, Lerner M. Health-Related Quality of Life Metrics in Patients With Retrograde Cricopharyngeus Dysfunction. Annals Of Otology Rhinology & Laryngology 2025, 134: 663-670. PMID: 40420548, DOI: 10.1177/00034894251342088.Peer-Reviewed Original ResearchPROMIS-29 questionnaireRetrograde cricopharyngeus dysfunctionPROMIS-29Quality of lifeLevels of anxietySubdomains of quality of lifeHealth-related quality of life metricsHealth-related qualitySocial Anxiety QuestionnaireAnxiety metricsQuality of life metricsPain impairmentReport anxietyMonitoring response to therapyLogistic regressionAnxiety QuestionnaireNational averageResponse to therapyMonitoring therapy responseQuestionnaireClinical questionsSocial anxietyAnxietySleep impairmentClinicians
2024
Patterns of Care for T1 Glottic Squamous Cell Carcinomas from 2004–2020
Malik D, Jacobs D, Fereydooni S, Park H, Mehra S. Patterns of Care for T1 Glottic Squamous Cell Carcinomas from 2004–2020. The Laryngoscope 2024, 134: 3633-3644. PMID: 38411338, DOI: 10.1002/lary.31363.Peer-Reviewed Original ResearchGlottic squamous cell carcinomaT1 glottic squamous cell carcinomaSquamous cell carcinomaDual-modality treatmentOver-treatmentT1a tumorsCell carcinomaTreatment regimensOverall treatment modalityNational Cancer DatabaseRate of surgeryYear of treatmentMultivariate logistic regressionCochran-Armitage testT1b tumorsT1b diseaseCancer DatabaseOver-treatedTreatment modalitiesTreatment patternsAssociated with greater likelihoodSurgeryPatientsTumorLogistic regressionDimeric Tubulin Modifies Mechanical Properties of Lipid Bilayer, as Probed Using Gramicidin A Channel
Rostovtseva T, Weinrich M, Jacobs D, Rosencrans W, Bezrukov S. Dimeric Tubulin Modifies Mechanical Properties of Lipid Bilayer, as Probed Using Gramicidin A Channel. International Journal Of Molecular Sciences 2024, 25: 2204. PMID: 38396879, PMCID: PMC10889239, DOI: 10.3390/ijms25042204.Peer-Reviewed Original ResearchConceptsRegulation of protein-protein interactionsProtein-protein interactionsNon-lamellar lipidsMembrane hydrophobic coreMembrane remodelingMechanical properties of lipid bilayersMembrane bindingProperties of lipid bilayersRegulatory functionsTubulin bindingTubulinHydrophobic regionLipid headgroupsHydrophobic coreCell proliferationLipid bilayerPlanar lipid membranesMembrane mechanical propertiesMembraneMolecular probesLipid packingLipidLipid membranesGramicidin A channelBinding
2023
Treatment, Management, and Otolaryngology Consultation for Epistaxis in the Emergency Room: An Institutional Experience
Jacobs D, Wang V, Chao J, Manes R, Lee Y. Treatment, Management, and Otolaryngology Consultation for Epistaxis in the Emergency Room: An Institutional Experience. American Journal Of Rhinology 2023, 38: 102-107. PMID: 38155492, DOI: 10.1177/19458924231223348.Peer-Reviewed Original ResearchENT consultationWhite patientsNeck surgeryOutside facilityCommon reasonPatient careRecent headMore white patientsRetrospective chart reviewEmergency department visitsNon-white patientsClinical care pathwayNonabsorbable packingAdult patientsChart reviewED visitsDepartment visitsED encountersOtolaryngology consultationED settingCare pathwayEmergency roomInstitutional experienceEpistaxisAbnormal anatomy
2022
Restricting α-synuclein transport into mitochondria by inhibition of α-synuclein–VDAC complexation as a potential therapeutic target for Parkinson’s disease treatment
Rajendran M, Queralt-Martín M, Gurnev P, Rosencrans W, Rovini A, Jacobs D, Abrantes K, Hoogerheide D, Bezrukov S, Rostovtseva T. Restricting α-synuclein transport into mitochondria by inhibition of α-synuclein–VDAC complexation as a potential therapeutic target for Parkinson’s disease treatment. Cellular And Molecular Life Sciences 2022, 79: 368. PMID: 35718804, PMCID: PMC11072225, DOI: 10.1007/s00018-022-04389-w.Peer-Reviewed Original ResearchConceptsVoltage-dependent anion channelVDAC poreProtein-membrane bindingRegulating mitochondrial functionProximity ligation assayInvolvement of alpha-synucleinMembrane bindingMitochondrial respirationMitochondrial functionHeLa cellsLigation assayLipid membranesHexokinase 2MitochondriaTranslocation processComplex inhibitionAnion channelFluorescence correlation spectroscopyAlpha-synucleinMolecular levelMitochondrial toxicityASynTranslocationPeptide therapeuticsTherapeutic target
2021
ASO Author Reflections: The Utility of Overall Survival as an Outcome in the Study of Merkel Cell Carcinoma
Esposito AC, Jacobs D, Olino K. ASO Author Reflections: The Utility of Overall Survival as an Outcome in the Study of Merkel Cell Carcinoma. Annals Of Surgical Oncology 2021, 29: 425-426. PMID: 34523003, DOI: 10.1245/s10434-021-10791-8.Commentaries, Editorials and LettersProlonged inpatient stay after upfront total laryngectomy is associated with overall survival
Jacobs D, Kafle S, Earles J, Rahmati R, Mehra S, Judson BL. Prolonged inpatient stay after upfront total laryngectomy is associated with overall survival. Laryngoscope Investigative Otolaryngology 2021, 6: 94-102. PMID: 33614936, PMCID: PMC7883619, DOI: 10.1002/lio2.441.Peer-Reviewed Original ResearchNational Cancer DatabaseTotal laryngectomyOverall survivalInpatient LOSMultivariable analysisCharlson-Deyo comorbidity scoreLong-term overall survivalPostoperative long-term mortalityMultivariable binary logistic regressionNinety-day mortalityUpfront total laryngectomyLong-term mortalityDays of diagnosisKaplan-Meier analysisBinary logistic regressionProlonged LOSComorbidity scoreWorse OSPatient ageCox regressionInpatient stayVolume centersClose surveillanceFemale sexInpatient lengthAssessment of Age, Period, and Birth Cohort Effects and Trends in Merkel Cell Carcinoma Incidence in the United States
Jacobs D, Huang H, Olino K, Weiss S, Kluger H, Judson BL, Zhang Y. Assessment of Age, Period, and Birth Cohort Effects and Trends in Merkel Cell Carcinoma Incidence in the United States. JAMA Dermatology 2021, 157: 59-65. PMID: 33146688, PMCID: PMC7643047, DOI: 10.1001/jamadermatol.2020.4102.Peer-Reviewed Original ResearchConceptsMerkel cell carcinomaBirth cohort effectsCell carcinomaIncidence rateCalendar periodBirth cohortPatient ageNew casesCohort effectsEnd Results Program databaseCross-sectional retrospective studyLongitudinal cohort studyHigh incidence rateAge-adjusted ratesRisk factor exposureRecent birth cohortsCohort studyCarcinoma incidenceRetrospective studyNeuroendocrine cancerAge effectsProgram databaseCohort analysisMAIN OUTCOMECarcinoma
2020
Tunable Electromechanical Nanopore Trap Reveals Populations of Peripheral Membrane Protein Binding Conformations
Hoogerheide D, Rostovtseva T, Jacobs D, Gurnev P, Bezrukov S. Tunable Electromechanical Nanopore Trap Reveals Populations of Peripheral Membrane Protein Binding Conformations. ACS Nano 2020, 15: 989-1001. PMID: 33369404, PMCID: PMC9019845, DOI: 10.1021/acsnano.0c07672.Peer-Reviewed Original ResearchConceptsVoltage-dependent anion channelMembrane surfaceSingle-molecule levelSame membrane surfaceIndividual proteinsAnion channelNeuronal proteinsLipid membranesBinding conformationsLipid surfaceLipid compositionProteinΑ-synucleinMembraneConformationOrders of magnitudeSurfaceUnbindingMitochondriaBindsObserved distributionNanoporesMoleculesΑSynTraps