2006
p16INK4a Modulates p53 in Primary Human Mammary Epithelial Cells
Zhang J, Pickering CR, Holst CR, Gauthier ML, Tlsty TD. p16INK4a Modulates p53 in Primary Human Mammary Epithelial Cells. Cancer Research 2006, 66: 10325-10331. PMID: 17079452, DOI: 10.1158/0008-5472.can-06-1594.Peer-Reviewed Original ResearchConceptsPrimary human mammary epithelial cellsHuman mammary epithelial cellsMammary epithelial cellsCell type-specific regulationTumor suppressor geneStabilization of p53Epithelial cellsP53 protein levelsE2F/Gene activityDownstream targetsCellular responsesSuppressor geneProteolytic degradationProtein levelsP53 proteinP16 proteinP53ProteinReduced levelsP53 statusPathwayCellsGenesRegulation
2005
p38 Regulates Cyclooxygenase-2 in Human Mammary Epithelial Cells and Is Activated in Premalignant Tissue
Gauthier ML, Pickering CR, Miller CJ, Fordyce CA, Chew KL, Berman HK, Tlsty TD. p38 Regulates Cyclooxygenase-2 in Human Mammary Epithelial Cells and Is Activated in Premalignant Tissue. Cancer Research 2005, 65: 1792-1799. PMID: 15753376, DOI: 10.1158/0008-5472.can-04-3507.Peer-Reviewed Original ResearchMeSH KeywordsApoptosisBreastBreast NeoplasmsCarcinoma, Intraductal, NoninfiltratingCell NucleusCell ProliferationCyclooxygenase 2CytoplasmEnzyme ActivationEnzyme InhibitorsEpithelial CellsFemaleGene Expression Regulation, EnzymologicHumansMembrane ProteinsMiddle AgedP38 Mitogen-Activated Protein KinasesPhosphorylationPrecancerous ConditionsProstaglandin-Endoperoxide SynthasesProstaglandinsTranscription, GeneticConceptsVariant human mammary epithelial cellsCOX-2 expressionCyclooxygenase-2Human mammary epithelial cellsEpithelial cellsMammary epithelial cellsNormal tissuesOverexpress COX-2COX-2 transcriptsDecreases cell survivalCOX-2 transcriptionRegulates Cyclooxygenase-2Ductal carcinomaPremalignant lesionsReduction mammoplastyBreast cancerNeoplastic processTargeted preventionPremalignant tissuesImmediate early genesEarly carcinogenesisUpstream regulatory pathwaysLesionsCell survivalTissue