2019
Disruption of TP63-miR-27a* Feedback Loop by Mutant TP53 in Head and Neck Cancer
Chari NS, Ivan C, Le X, Li J, Mijiti A, Patel AA, Osman AA, Peterson CB, Williams MD, Pickering CR, Caulin C, Myers JN, Calin GA, Lai SY. Disruption of TP63-miR-27a* Feedback Loop by Mutant TP53 in Head and Neck Cancer. Journal Of The National Cancer Institute 2019, 112: 266-277. PMID: 31124563, PMCID: PMC7073912, DOI: 10.1093/jnci/djz097.Peer-Reviewed Original ResearchMeSH KeywordsCase-Control StudiesChromatin ImmunoprecipitationFeedback, PhysiologicalHead and Neck NeoplasmsHumansMicroRNAsMouth NeoplasmsMutationNeoplasm StagingPromoter Regions, GeneticSquamous Cell Carcinoma of Head and NeckSurvival RateTranscription FactorsTranscription, GeneticTumor Suppressor Protein p53Tumor Suppressor ProteinsConceptsMutant TP53Neck squamous cell carcinomaSquamous cell carcinomaHNSCC cell linesInhibits tumor growthEpidermal growth factor receptorFrequent eventRole of TP53PI3K pathwayGrowth factor receptorCancer Genome AtlasCell carcinomaNeck cancerHNSCC samplesPoor survivalEpidermal growth factorTumor growthVivo findingsTumor progressionPatient samplesTumor samplesTumor survivalTumor cellsNormal tissuesNovel target
2005
p38 Regulates Cyclooxygenase-2 in Human Mammary Epithelial Cells and Is Activated in Premalignant Tissue
Gauthier ML, Pickering CR, Miller CJ, Fordyce CA, Chew KL, Berman HK, Tlsty TD. p38 Regulates Cyclooxygenase-2 in Human Mammary Epithelial Cells and Is Activated in Premalignant Tissue. Cancer Research 2005, 65: 1792-1799. PMID: 15753376, DOI: 10.1158/0008-5472.can-04-3507.Peer-Reviewed Original ResearchMeSH KeywordsApoptosisBreastBreast NeoplasmsCarcinoma, Intraductal, NoninfiltratingCell NucleusCell ProliferationCyclooxygenase 2CytoplasmEnzyme ActivationEnzyme InhibitorsEpithelial CellsFemaleGene Expression Regulation, EnzymologicHumansMembrane ProteinsMiddle AgedP38 Mitogen-Activated Protein KinasesPhosphorylationPrecancerous ConditionsProstaglandin-Endoperoxide SynthasesProstaglandinsTranscription, GeneticConceptsVariant human mammary epithelial cellsCOX-2 expressionCyclooxygenase-2Human mammary epithelial cellsEpithelial cellsMammary epithelial cellsNormal tissuesOverexpress COX-2COX-2 transcriptsDecreases cell survivalCOX-2 transcriptionRegulates Cyclooxygenase-2Ductal carcinomaPremalignant lesionsReduction mammoplastyBreast cancerNeoplastic processTargeted preventionPremalignant tissuesImmediate early genesEarly carcinogenesisUpstream regulatory pathwaysLesionsCell survivalTissue