p16INK4a Modulates p53 in Primary Human Mammary Epithelial Cells
Zhang J, Pickering CR, Holst CR, Gauthier ML, Tlsty TD. p16INK4a Modulates p53 in Primary Human Mammary Epithelial Cells. Cancer Research 2006, 66: 10325-10331. PMID: 17079452, DOI: 10.1158/0008-5472.can-06-1594.Peer-Reviewed Original ResearchConceptsPrimary human mammary epithelial cellsHuman mammary epithelial cellsMammary epithelial cellsCell type-specific regulationTumor suppressor geneStabilization of p53Epithelial cellsP53 protein levelsE2F/Gene activityDownstream targetsCellular responsesSuppressor geneProteolytic degradationProtein levelsP53 proteinP16 proteinP53ProteinReduced levelsP53 statusPathwayCellsGenesRegulation