Primary hyperparathyroidism with normal baseline intraoperative parathyroid hormone: A challenging population
Javid M, Callender G, Quinn C, Carling T, Donovan P, Udelsman R. Primary hyperparathyroidism with normal baseline intraoperative parathyroid hormone: A challenging population. Surgery 2016, 161: 493-498. PMID: 27712879, DOI: 10.1016/j.surg.2016.08.018.Peer-Reviewed Original ResearchMeSH KeywordsAcademic Medical CentersAdultAge FactorsAgedAged, 80 and overAlgorithmsCohort StudiesFemaleFollow-Up StudiesHumansHyperparathyroidism, PrimaryMaleMiddle AgedMonitoring, IntraoperativeParathyroid HormoneParathyroidectomyPredictive Value of TestsReference ValuesRetrospective StudiesRisk AssessmentSeverity of Illness IndexSex FactorsTreatment OutcomeYoung AdultConceptsIntraoperative parathyroid hormonePrimary hyperparathyroidismParathyroid hormoneSurgeon's judgmentIntraoperative parathyroid hormone levelsParathyroid hormone levelsDouble adenomasMultigland hyperplasiaMultigland diseaseConsecutive patientsMedian ageOperative findingsOperative patientsSingle adenomaRetrospective reviewSingle institutionHormone levelsHigh incidenceNormal rangePatientsPredictive valuePg/HyperparathyroidismSurgical judgmentOptimal outcomesShifting patterns of genomic variation in the somatic evolution of papillary thyroid carcinoma
Rubinstein JC, Brown TC, Christison-Lagay ER, Zhang Y, Kunstman JW, Juhlin CC, Nelson-Williams C, Goh G, Quinn CE, Callender GG, Udelsman R, Lifton RP, Korah R, Carling T. Shifting patterns of genomic variation in the somatic evolution of papillary thyroid carcinoma. BMC Cancer 2016, 16: 646. PMID: 27538953, PMCID: PMC4989347, DOI: 10.1186/s12885-016-2665-7.Peer-Reviewed Original ResearchConceptsSingle nucleotide substitutionSomatic evolutionCommon ancestor cellGenomic changesNucleotide substitutionsTissue typesTissue-specific signaturesGenomic divergenceGenomic variationGenomic instabilityGenomic signaturesRisk of tumorigenesisSelective pressurePTC tumorigenesisTumor genomesAncestor cellsGenomeA transversionMethodsExome sequencingDiverse mutationsSomatic eventsMutational spectrumT transitionNovel patternTumorigenesis