2024
From standard therapies to monoclonal antibodies and immune checkpoint inhibitors – an update for reconstructive surgeons on common oncological cases
Knoedler L, Huelsboemer L, Hollmann K, Alfertshofer M, Herfeld K, Hosseini H, Boroumand S, Stoegner V, Safi A, Perl M, Knoedler S, Pomahac B, Kauke-Navarro M. From standard therapies to monoclonal antibodies and immune checkpoint inhibitors – an update for reconstructive surgeons on common oncological cases. Frontiers In Immunology 2024, 15: 1276306. PMID: 38715609, PMCID: PMC11074450, DOI: 10.3389/fimmu.2024.1276306.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, MonoclonalAntineoplastic Agents, ImmunologicalHumansImmune Checkpoint InhibitorsNeoplasmsPlastic Surgery ProceduresConceptsImmune checkpoint inhibitorsHead and neck cancerBreast cancerMonoclonal antibodiesCheckpoint inhibitorsSkin cancerReconstructive surgeryNon-surgical treatment strategiesProlonged progression-free survivalSuboptimal treatment plansProgression-free survivalNon-surgical therapySurgical tumor resectionImpaired patient outcomeStandardized treatment algorithmSurgical therapy planningAnti-cancer strategyUnresectable tumorsConventional chemotherapyRemission rateTumor resectionCurative therapyTargeted therapyNeck cancerOncology cases
2023
Vascularized Composite Allograft Versus Prosthetic for Reconstruction After Facial and Hand Trauma
Noel O, Dumbrava M, Daoud D, Kammien A, Kauke-Navarro M, Pomahac B, Colen D. Vascularized Composite Allograft Versus Prosthetic for Reconstruction After Facial and Hand Trauma. Annals Of Plastic Surgery 2023, 92: 100-105. PMID: 37962243, DOI: 10.1097/sap.0000000000003731.Peer-Reviewed Original ResearchMeSH KeywordsComposite Tissue AllograftsFacial InjuriesHumansPlastic Surgery ProceduresUpper ExtremityVascularized Composite AllotransplantationConceptsHand traumaHand/upper extremityLong-term outcomesUpper extremity traumaDifferent reconstructive optionsUse of prosthesesExtremity traumaBenefit profileUpper extremityReconstructive optionsComposite allotransplantationFace traumaHand reconstructionTraumaClinical realityPrimary optionProsthesisPatientsVCA
2019
Multidisciplinary Treatment to Restore Vision in Ocular Burns
Christensen J, Shanbhag S, Shih G, Goverman J, Pomahac B, Chodosh J, Ehrlichman R. Multidisciplinary Treatment to Restore Vision in Ocular Burns. Journal Of Burn Care & Research 2019, 41: 859-865. PMID: 31808803, DOI: 10.1093/jbcr/irz201.Peer-Reviewed Original ResearchConceptsSplit-thickness skin graftFull-thickness skin graftKeratoprosthesis placementSkin graftsCorneal blindnessLight perceptionBilateral corneal blindnessGood visual prognosisConsecutive burn patientsLoss of visionMucous membrane graftPeriorbital soft tissueVisual prognosisChart reviewCorneal scarringMultidisciplinary treatmentPostoperative visionInitial treatmentBurn patientsCorneal injuryCicatricial ectropionOcular burnsTear productionMembrane graftGlobe protection
2018
Trismus in Face Transplantation Following Ballistic Trauma
Krezdorn N, Alhefzi M, Perry B, Aycart M, Tasigiorgos S, Bueno E, Green J, Pribaz J, Pomahac B, Caterson E. Trismus in Face Transplantation Following Ballistic Trauma. Journal Of Craniofacial Surgery 2018, 29: 843-847. PMID: 29381613, DOI: 10.1097/scs.0000000000004271.Peer-Reviewed Original ResearchMeSH KeywordsAdultFaceFacial TransplantationHumansMalePlastic Surgery ProceduresPostoperative ComplicationsRange of Motion, ArticularTrismusWounds, GunshotConceptsFace transplant recipientsTemporomandibular jointFace transplantationTransplant recipientsFunctional outcomeBallistic traumaMouth openingImpaired mouth openingOral food intakeImmediate postoperative periodBallistic injuriesRange of motionPartial face transplantationCovert injuriesIntraoperative releasePersistent trismusTotal condylectomyYear posttransplantPostoperative periodPostoperative planningPostoperative treatmentPrimary injuryIntraoperative evaluationSevere scarringMedical recordsExtracorporeal Perfusion in Vascularized Composite Allotransplantation
Kueckelhaus M, Puscz F, Dermietzel A, Dadras M, Fischer S, Krezdorn N, Pomahac B, Hirsch T. Extracorporeal Perfusion in Vascularized Composite Allotransplantation. Annals Of Plastic Surgery 2018, 80: 669-678. PMID: 29746324, DOI: 10.1097/sap.0000000000001477.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsExtracorporeal CirculationForecastingHumansPlastic Surgery ProceduresVascularized Composite AllotransplantationConceptsVascularized Composite AllotransplantationSolid organ transplantationIschemia timeMachine perfusionOrgan transplantationReconstructive surgeryComposite allotransplantationClinical solid organ transplantationMachine perfusion systemImmunosuppressive treatmentGraft immunogenicityBroad clinical applicationLifelong monitoringTherapeutic measuresPerfusion strategyClinical successSevere injuriesPerfusion solutionPreclinical trialsClinical settingPlastic surgeryPerfusionImmunogenicityPerfusion systemClinical applicationFacial restoration by transplantation
Kollar B, Pomahac B. Facial restoration by transplantation. The Surgeon 2018, 16: 245-249. PMID: 29490887, DOI: 10.1016/j.surge.2018.01.003.Peer-Reviewed Original ResearchMeSH KeywordsAdultFacial InjuriesFacial TransplantationFemaleHumansMaleMiddle AgedPlastic Surgery ProceduresConceptsWorld War I.World War IIModern plastic surgerySir Harold GilliesPeter Bent Brigham HospitalWar IIFace transplantationFirst successful kidney transplantationJoseph MurraySuccessful kidney transplantationNobel PrizeWorldFacial restorationKidney transplantationTransplant cohortUnique patientsWomen's HospitalSkin graftsOrgan transplantationTransplantationHospitalPlastic surgeonsPlastic surgerySoldiersBattlefield
2016
The role of face transplantation in the self-inflicted gunshot wound
Kiwanuka H, Aycart M, Gitlin D, Devine E, Perry B, Win T, Bueno E, Alhefzi M, Krezdorn N, Pomahac B. The role of face transplantation in the self-inflicted gunshot wound. Journal Of Plastic Reconstructive & Aesthetic Surgery 2016, 69: 1636-1647. PMID: 27720683, DOI: 10.1016/j.bjps.2016.08.014.Peer-Reviewed Original ResearchMeSH KeywordsAdultBone TransplantationDecision Making, Computer-AssistedFacial InjuriesFacial TransplantationFemaleHumansMaleMass ScreeningMiddle AgedPatient SatisfactionPlastic Surgery ProceduresPsychological TechniquesRetrospective StudiesSelf-Injurious BehaviorSurgical FlapsTreatment OutcomeUnited StatesWounds, GunshotConceptsSelf-inflicted gunshot woundsFace transplantationGunshot woundsFT recipientsPsychosocial outcomesSubset of patientsPartial face transplantationFree tissue transferLoco-regional flapsSerial debridementConventional reconstructionWomen's HospitalMultidisciplinary evaluationRetrospective analysisAesthetic deficitsNormal restorationSoft tissue repairMental illnessTissue transferReconstructive surgeonPsychosocial componentsSuicidal behaviorScreening processMidfacial defectsRecipientsSurgical Optimization of Motor Recovery in Face Transplantation
Aycart M, Perry B, Alhefzi M, Bueno E, Kueckelhaus M, Fischer S, Pomahac B. Surgical Optimization of Motor Recovery in Face Transplantation. Journal Of Craniofacial Surgery 2016, 27: 286-292. PMID: 26967066, DOI: 10.1097/scs.0000000000002305.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentChildChild, PreschoolCleft LipCleft PalateCohort StudiesComorbidityCross InfectionFacial MusclesFacial NerveFacial TransplantationFemaleHospitals, PediatricHumansInfantInfant, NewbornMaleMotor NeuronsNerve TransferPlastic Surgery ProceduresPostoperative ComplicationsQuality ImprovementReoperationRetrospective StudiesRisk AdjustmentSmilingSurgical Wound InfectionConceptsMotor recoveryPatient 2Nerve transferNerve graftingPatient 1Devastating facial injuriesFacial nerve stumpFacial nerve reconstructionManual muscle testingFull face transplantIntraoperative soft tissueFacial nerve managementPrinciples of managementGradual improvementMuscle testingNerve reconstructionNerve stumpChallenging patientsMotor functionRetrospective analysisSensory restorationPatient's abilitySatisfactory motorFacial injuriesNerve management
2015
Reconstructive Management of Devastating Electrical Injuries to the Face
Janis J, Khansa I, Lehrman C, Orgill D, Pomahac B. Reconstructive Management of Devastating Electrical Injuries to the Face. Plastic & Reconstructive Surgery 2015, 136: 839-847. PMID: 26090762, DOI: 10.1097/prs.0000000000001619.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBurns, ElectricFacial InjuriesFacial TransplantationFree Tissue FlapsHumansMaleMiddle AgedPlastic Surgery ProceduresRetrospective StudiesTreatment OutcomeYoung AdultConceptsElectrical injuryFace transplantationCase seriesTrauma centerReconstructive challengeLevel 1 trauma centerCLINICAL QUESTION/LEVELRetrospective case seriesLarge case seriesCare of patientsLife-threatening injuriesComposite tissue allotransplantationSignificant reconstructive challengePotential recipient vesselsReconstructive managementRenal impairmentAntigen sensitizationInitial managementElectrical burnsReconstructive proceduresMicrosurgical reconstructionPatient injuryRecipient vesselsCardiac arrhythmiasTissue allotransplantationFacial Restoration by Transplantation
Westvik T, Dermietzel A, Pomahac B. Facial Restoration by Transplantation. Annals Of Plastic Surgery 2015, 74: s2-s8. PMID: 25875907, DOI: 10.1097/sap.0000000000000525.Peer-Reviewed Original ResearchCost Analysis of Conventional Face Reconstruction versus Face Transplantation for Large Tissue Defects
Nguyen L, Naunheim M, Hevelone N, Diaz-Siso J, Hogan J, Bueno E, Caterson E, Pomahac B. Cost Analysis of Conventional Face Reconstruction versus Face Transplantation for Large Tissue Defects. Plastic & Reconstructive Surgery 2015, 135: 260-267. PMID: 25539310, DOI: 10.1097/prs.0000000000000799.Peer-Reviewed Original ResearchMeSH KeywordsAdultAllograftsCosts and Cost AnalysisFaceFacial TransplantationFemaleHumansMaleMiddle AgedPlastic Surgery ProceduresConceptsFacial allograft transplantationAllograft transplantationOne-year costsReconstruction patientsTissue defectsMedical Consumer Price IndexHospital billing recordsFacial tissue defectsLarge tissue defectsGlobal immunosuppressionTransplantation recipientsDepartment costsTransplantation cohortConventional reconstructionDead donorsImmunologic rejectionTreatment modalitiesPatient costsHypothetical cohortTransplantationBilling recordsCase severityFacial deficitsPatientsFacial allograft
2014
The Advent of the Restorative Plastic Surgeon
Carty M, Pribaz J, Talbot S, Caterson E, Pomahac B. The Advent of the Restorative Plastic Surgeon. Plastic & Reconstructive Surgery 2014, 133: 182-186. PMID: 24374677, DOI: 10.1097/01.prs.0000436806.35294.e0.Peer-Reviewed Original Research
2013
Lessons Learned from Simultaneous Face and Bilateral Hand Allotransplantation
Carty M, Hivelin M, Dumontier C, Talbot S, Benjoar M, Pribaz J, Lantieri L, Pomahac B. Lessons Learned from Simultaneous Face and Bilateral Hand Allotransplantation. Plastic & Reconstructive Surgery 2013, 132: 423-432. PMID: 23584623, DOI: 10.1097/prs.0b013e318295883d.Peer-Reviewed Original Research
2012
Craniofacial Principles in Face Transplantation
Caterson E, Diaz-Siso J, Shetye P, Junker J, Bueno E, Soga S, Rybicki F, Pomahac B. Craniofacial Principles in Face Transplantation. Journal Of Craniofacial Surgery 2012, 23: 1234-1238. PMID: 22948648, DOI: 10.1097/scs.0b013e318252d406.Peer-Reviewed Original ResearchConceptsSkull baseFace transplantationFace transplantFace transplant recipientsSella-nasion planeSoft tissue elementsTransplant recipientsAirway functionDonor allograftsAnatomical restorationUpper airwayCraniofacial principlesPostoperative analysisNormal anatomyTransplantationFrankfort horizontal planeSoft tissueHard tissue componentsFunctional effectsCephalometric parametersOrthognathic planningTissue elementsTransplantNormative dataTissue componentsVascularized Composite Allotransplantation Research: The Emerging Field
Pomahac B, Becker Y, Cendales L, Ildstad S, Li X, Schneeberger S, Siemionow M, Thomson A, Zheng X, Tullius S. Vascularized Composite Allotransplantation Research: The Emerging Field. American Journal Of Transplantation 2012, 12: 1062-1063. PMID: 22225551, DOI: 10.1111/j.1600-6143.2011.03900.x.Peer-Reviewed Original ResearchHumansPlastic Surgery ProceduresTissue TransplantationTransplantation ImmunologyTransplantation, HomologousThe Brigham and Women's Hospital Face Transplant Program
Singhal D, Pribaz J, Pomahac B. The Brigham and Women's Hospital Face Transplant Program. Plastic & Reconstructive Surgery 2012, 129: 81e-88e. PMID: 22186587, DOI: 10.1097/prs.0b013e31823621db.Peer-Reviewed Original ResearchFacial Composite Tissue Allograft
Pomahac B, Pribaz J. Facial Composite Tissue Allograft. Journal Of Craniofacial Surgery 2012, 23: 265-267. PMID: 22337422, DOI: 10.1097/scs.0b013e318241b8b8.Peer-Reviewed Original ResearchConceptsSuperficial temporal vesselsTemporal vesselsPeripheral facial nerve branchesComposite tissue allograftsFacial nerve branchesExternal auditory canalHair-bearing scalpComplete sensoryOcular ischemiaOropharyngeal dysfunctionNerve branchesAuditory canalFacial nerveDifficult dissectionTissue allograftsNerve connectionsPreauricular areaCarotid anastomosisMuscle insertionFacial vesselsFacial allograftFunctional problemsSoft tissueDissectionAllografts
2011
Three Patients with Full Facial Transplantation
Pomahac B, Pribaz J, Eriksson E, Bueno E, Diaz-Siso J, Rybicki F, Annino D, Orgill D, Caterson E, Caterson S, Carty M, Chun Y, Sampson C, Janis J, Alam D, Saavedra A, Molnar J, Edrich T, Marty F, Tullius S. Three Patients with Full Facial Transplantation. New England Journal Of Medicine 2011, 366: 715-722. PMID: 22204672, DOI: 10.1056/nejmoa1111432.Peer-Reviewed Original ResearchConceptsFull face transplantFull facial transplantationFacial transplantationAcute rejectionPostoperative complicationsSensory nervesSevere deformityFunctional restorationPatientsSingle episodeFacial allograftTransplantationFacial appearanceConventional reconstructionComplicationsAllograftsNerveGlucocorticoidsTransplantDeformityCoaptationMonthsPreoperative Vascular Mapping for Facial Allotransplantation
Soga S, Pomahac B, Mitsouras D, Kumamaru K, Powers S, Prior R, Signorelli J, Bueno E, Steigner M, Rybicki F. Preoperative Vascular Mapping for Facial Allotransplantation. Plastic & Reconstructive Surgery 2011, 128: 883-891. PMID: 21921764, DOI: 10.1097/prs.0b013e3182268b43.Peer-Reviewed Original ResearchEstablishing a Composite Tissue Allotransplantation Program
Pomahac B. Establishing a Composite Tissue Allotransplantation Program. Journal Of Reconstructive Microsurgery 2011, 28: 03-06. PMID: 21811966, DOI: 10.1055/s-0031-1285823.Peer-Reviewed Original ResearchConceptsComposite tissue allotransplantationPromising surgical optionPotential patient safety issuesLife-long immunosuppressionPatient safety issuesClinical research interestInstitutional review boardSurgical optionsPostoperative costsWomen's HospitalTissue allotransplantationMultidisciplinary teamMedical careCTA programReview boardHospital administrationLogistic hurdlesMedical insuranceHospitalAdministrationUnited StatesSafety issuesImmunosuppressionPatientsAllotransplantation