2024
Manifestations of human atherosclerosis across vascular beds
Jovin D, Sumpio B, Greif D. Manifestations of human atherosclerosis across vascular beds. JVS-Vascular Insights 2024, 2: 100089. DOI: 10.1016/j.jvsvi.2024.100089.Peer-Reviewed Original ResearchVascular bedClinical managementCarotid arteryCommon risk factorsPeripheral arterial diseaseManagement of carotidClinical management of atherosclerosisEtiology of mortalityIntervention outcomesModel of atherogenesisPathology of atherosclerotic lesionsMedical therapyMeta-analysesTreatment responseFibrotic componentManagement of atherosclerosisLower extremitiesMale sexClinical studiesArtery diseaseMetabolic factorsPeripheral atherosclerosisRisk factorsIndividual patientsVascular territories
2023
Premature atherosclerosis: A review of current literature
Neifert A, Su D, Chaar C, Sumpio B. Premature atherosclerosis: A review of current literature. JVS-Vascular Insights 2023, 1: 100013. DOI: 10.1016/j.jvsvi.2023.100013.Peer-Reviewed Original ResearchRisk factorsAtherosclerotic diseaseClinical manifestationsGenetic predispositionTraditional atherosclerotic risk factorsHuman immunodeficiency virus (HIV) infectionNontraditional risk factorsActive antiretroviral therapyAtherosclerotic risk factorsImmunodeficiency virus infectionPeripheral arterial diseaseCerebral vascular diseasePremature atherosclerotic diseaseUnique risk factorsRecreational substance useAntiretroviral therapyAutoimmune conditionsDisease-associated lossMetabolic syndromeArterial diseasePremature atherosclerosisLipid derangementsMyocardial infarctionVascular diseaseVirus infection
2017
Distal embolization during lower extremity endovascular interventions
Chaar C, Shebl F, Sumpio B, Dardik A, Indes J, Sarac T. Distal embolization during lower extremity endovascular interventions. Journal Of Vascular Surgery 2017, 66: 143-150. PMID: 28366300, DOI: 10.1016/j.jvs.2017.01.032.Peer-Reviewed Original ResearchMeSH KeywordsAgedAmputation, SurgicalAngioplasty, BalloonAtherectomyChi-Square DistributionCritical IllnessDatabases, FactualDisease-Free SurvivalEmbolismFemaleFemoral ArteryHumansIncidenceIntermittent ClaudicationIschemiaLimb SalvageLower ExtremityMaleMiddle AgedMultivariate AnalysisNew EnglandOdds RatioPeripheral Arterial DiseaseProportional Hazards ModelsRegistriesRetrospective StudiesRisk AssessmentRisk FactorsStentsTime FactorsTreatment OutcomeVascular PatencyConceptsLower extremity endovascular interventionsSuperficial femoral arteryCritical limb ischemiaDistal embolizationLoss of patencyEndovascular interventionBalloon angioplastyLimb ischemiaAdditional endovascular interventionArterial endovascular interventionUse of atherectomyVascular Study GroupLength of occlusionNew England databaseNumber of arteriesMajor amputationMost patientsPatient characteristicsFemoral arteryRisk factorsStudy groupMultivariable regressionLimb lossLower riskAngioplasty
2016
Systemic and cell-specific mechanisms of vasculopathy induced by human immunodeficiency virus and highly active antiretroviral therapy
Haser GC, Sumpio B. Systemic and cell-specific mechanisms of vasculopathy induced by human immunodeficiency virus and highly active antiretroviral therapy. Journal Of Vascular Surgery 2016, 65: 849-859. PMID: 26994951, DOI: 10.1016/j.jvs.2016.01.036.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusActive antiretroviral therapySmooth muscle cellsAntiretroviral therapyHIV patientsImmunodeficiency virusTraditional cardiovascular risk factorsMuscle cellsEndothelial cellsCardiovascular risk factorsChronic immune activationSerious cardiovascular eventsDevelopment of atherosclerosisVascular systemCardiovascular eventsVascular complicationsHIV medicationsChronic inflammationImmune activationMyocardial infarctionRisk factorsCell-specific mechanismsGeneral populationCholesterol metabolismCardiovascular pathologyWine, Polyphenols, and Cardioprotection
Sumpio B, Cordova A, Sumpio B. Wine, Polyphenols, and Cardioprotection. Nutrition And Health 2016, 97-108. DOI: 10.1007/978-3-319-27969-5_8.Peer-Reviewed Original Research
2015
Consequences of hypogastric artery ligation, embolization, or coverage
Chitragari G, Schlosser FJ, Chaar C, Sumpio BE. Consequences of hypogastric artery ligation, embolization, or coverage. Journal Of Vascular Surgery 2015, 62: 1340-1347.e1. PMID: 26386508, DOI: 10.1016/j.jvs.2015.08.053.Peer-Reviewed Original ResearchConceptsVascular surgery patientsHypogastric arteryIschemic complicationsVascular surgeryProximal interruptionSurgery patientsComplication rateMedian ageOncology patientsRisk factorsSignificant differencesHypogastric artery ligationIschemic complication rateDevelopment of complicationsSpinal cord ischemiaData of patientsClear risk factorsButtock claudicationButtock necrosisColonic ischemiaCord ischemiaBilateral embolizationDistal embolizationProximal embolizationControlled Trials
2011
Cardiovascular disease: the new epidemic in sub-Saharan Africa
Ikem I, Sumpio BE. Cardiovascular disease: the new epidemic in sub-Saharan Africa. Vascular 2011, 19: 301-307. PMID: 21940758, DOI: 10.1258/vasc.2011.ra0049.Peer-Reviewed Original ResearchConceptsCVD risk factorsRisk factorsCurrent human immunodeficiency virus (HIV) epidemicHuman immunodeficiency virus (HIV) epidemicDouble burdenNew epidemicCardiovascular disease preventionCoronary heart diseasePrevalence of CVDCause of deathNon-communicable diseasesHIV/CVD deathImmunodeficiency syndromeCVD diseaseEpidemiological shiftHeart diseaseSmoking ratesDisease preventionCurrent epidemicDiseaseVirus epidemicDiabetesEpidemicHigh rate
2009
Polyphenols are medicine: Is it time to prescribe red wine for our patients?
Cordova A, Sumpio B. Polyphenols are medicine: Is it time to prescribe red wine for our patients? International Journal Of Angiology 2009, 18: 111-117. PMID: 22477510, PMCID: PMC2903024, DOI: 10.1055/s-0031-1278336.Peer-Reviewed Original ResearchLow physical activityNumerous epidemiological studiesVascular diseaseRisk factorsCardiovascular diseaseChronic pathologiesPhysical activityEpidemiological studiesModerate consumptionElevated smokingFrench paradoxRed wineHigh consumptionDiseaseHigh levelsPolyphenolsSmokingPatientsCancerMortalityPathologyPrevention
2005
Homocysteine promotes p38-dependent chemotaxis in bovine aortic smooth muscle cells
Akasaka K, Akasaka N, Di Luozzo G, Sasajima T, Sumpio BE. Homocysteine promotes p38-dependent chemotaxis in bovine aortic smooth muscle cells. Journal Of Vascular Surgery 2005, 41: 517-522. PMID: 15838488, DOI: 10.1016/j.jvs.2004.12.043.Peer-Reviewed Original ResearchConceptsEffect of homocysteineMigration of SMCsLevels of homocysteineProgressive intimal thickeningAortic smooth muscle cellsSmooth muscle cell migrationBovine aortic smooth muscle cellsPotential therapeutic implicationsSmooth muscle cellsP38 activationExposure of SMCMuscle cell migrationSMC chemotaxisRisk factorsSelective blockadeIntimal thickeningTherapeutic implicationsP38-dependent pathwaySMC proliferationBoyden chamberChemotactic potentialMuscle cellsHomocysteineFetal bovine serumP38 inhibitor
2004
Molecular and biological effects of hemodynamics on vascular cells.
Pradhan S, Sumpio B. Molecular and biological effects of hemodynamics on vascular cells. Frontiers In Bioscience-Landmark 2004, 9: 3276-85. PMID: 15353357, DOI: 10.2741/1480.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAtherosclerosisCell MovementCell ProliferationCells, CulturedCyclic AMPDiglyceridesDisease ProgressionEndothelial CellsExtracellular MatrixHemodynamicsHumansInositol 1,4,5-TrisphosphateIntercellular Adhesion Molecule-1Plasminogen ActivatorsProtein Kinase CRisk FactorsStress, MechanicalConceptsEndothelial cellsSignificant atherosclerotic plaqueSystemic risk factorsTissue plasminogen activatorCellular adhesion moleculesCurrent pertinent literatureCultured endothelial cellsRisk factorsSecond messenger systemsSignificant lesionsProtein kinase C pathwayICAM-1Atherosclerosis formationAtherosclerotic plaquesVascular anatomyKinase C pathwayNitric oxideVascular cellsPlasminogen activatorAdhesion moleculesBlood vesselsVascular biologyMessenger systemsVessel wallPertinent literature
2000
Foot Ulcers
Sumpio BE. Foot Ulcers. New England Journal Of Medicine 2000, 343: 787-793. PMID: 10984568, DOI: 10.1056/nejm200009143431107.Peer-Reviewed Original ResearchConceptsPrimary care physiciansComprehensive treatment protocolMajor amputationPedal woundsAggressive treatmentFoot complicationsCare physiciansFoot ulcersVascular diseaseEarly recognitionRisk factorsPatient educationBiomechanical abnormalitiesTreatment protocolPrevents infectionOptimal managementSkin integrityCareful assessmentMultidisciplinary approachInfectionUlcerationComplicationsUlcersAmputationManagement
1999
Localization of Atherosclerosis: Role of Hemodynamics
Frangos S, Gahtan V, Sumpio B. Localization of Atherosclerosis: Role of Hemodynamics. JAMA Surgery 1999, 134: 1142-1149. PMID: 10522862, DOI: 10.1001/archsurg.134.10.1142.Peer-Reviewed Original ResearchConceptsEndothelial cell structureCoronary arteryAortic archRisk factorsAbdominal aortaChronic diseasesVascular endotheliumCircumferential strainRole of hemodynamicsLesionsHemodynamic forcesCyclic circumferential strainMajor branchesSusceptible sitesAtherosclerosisArteryAortaHemodynamicsAtherogenesisEndotheliumDisease
1993
Lipoprotein (a): A Risk Factor for Peripheral Vascular Disease
Widmann M, Sumpio B. Lipoprotein (a): A Risk Factor for Peripheral Vascular Disease. Annals Of Vascular Surgery 1993, 7: 446-451. PMID: 8268090, DOI: 10.1007/bf02002128.Peer-Reviewed Original ResearchConceptsPeripheral vascular diseaseCoronary artery diseaseDiabetes mellitusCigarette smokingRisk factorsCerebrovascular atherosclerotic diseaseWhite male patientArtery diseaseMale patientsAtherosclerotic diseasePlasma levelsVascular diseasePatientsDiseaseSerum proteinsMellitusComplicationsSmokingLipoprotein