2022
Heterogeneity in the guidelines for the management of diabetic foot disease in the Caribbean
Sumpio B, McConnie S, Maharaj D. Heterogeneity in the guidelines for the management of diabetic foot disease in the Caribbean. PLOS Global Public Health 2022, 2: e0000446. PMID: 36962244, PMCID: PMC10021831, DOI: 10.1371/journal.pgph.0000446.Peer-Reviewed Original ResearchDiabetic foot diseaseDF diseaseFoot diseaseMultidisciplinary teamLower extremity amputation ratesAmputation ratePodiatric careDiabetes mellitusSubsequent amputationInternational Working GroupVascular surgeryDiseaseHealth careMultidisciplinary approachDF problemMinority of countriesCareGuidelinesImplementation of strategiesCaribbean countriesStructured programWorking GroupRespondent countriesMellitusSurgeryPROGNOSTIC VALIDITY OF FRAILTY ASSESSMENT TOOLS IN PREDICTION OF MORTALITY AND MAJOR AMPUTATION IN PATIENTS UNDERGOING REVASCULARIZATION FOR LOWER EXTREMITY ARTERIAL DISEASE
Nikooie R, Smolderen K, Al-Damluji M, Meng C, Dai F, Nanna M, Sumpio B, Henke P, Mena-Hurtado C. PROGNOSTIC VALIDITY OF FRAILTY ASSESSMENT TOOLS IN PREDICTION OF MORTALITY AND MAJOR AMPUTATION IN PATIENTS UNDERGOING REVASCULARIZATION FOR LOWER EXTREMITY ARTERIAL DISEASE. Journal Of The American College Of Cardiology 2022, 79: 1779. DOI: 10.1016/s0735-1097(22)02770-x.Peer-Reviewed Original Research
2019
Role of Angiosomes in Guiding Target Intervention for Open Procedures
Citoni G, Taurino M, Sumpio B. Role of Angiosomes in Guiding Target Intervention for Open Procedures. 2019, 323-332. DOI: 10.1007/978-3-319-17918-6_25.Peer-Reviewed Original ResearchPeripheral arterial diseaseCritical limb ischemiaTarget vesselExtensive tissue lossQuality of lifeIschemic tissue lesionsLimb ischemiaLimb salvageArterial diseaseSevere progressionProlonging survivalOpen procedureLeg amputationPedal archTissue lesionsTissue lossIndividualized approachPatientsTarget interventionsAnatomic conceptsRevascularizationDiseaseInterventionBest vesselVessels
2016
Wine, Polyphenols, and Cardioprotection
Sumpio B, Cordova A, Sumpio B. Wine, Polyphenols, and Cardioprotection. Nutrition And Health 2016, 97-108. DOI: 10.1007/978-3-319-27969-5_8.Peer-Reviewed Original Research
2015
Preliminary Results of a Smoking Cessation Intervention for Patients With Peripheral Vascular Disease (PVD): A Randomized Controlled Study
Rajaee S, Holder T, Indes J, Muhs B, Sarac T, Sumpio B, Toll B, Chaar C. Preliminary Results of a Smoking Cessation Intervention for Patients With Peripheral Vascular Disease (PVD): A Randomized Controlled Study. Journal Of Vascular Surgery 2015, 61: 88s. DOI: 10.1016/j.jvs.2015.04.171.Peer-Reviewed Original Research
2013
Diabetes Mellitus and Peripheral Vascular Disease Diagnosis and Management
Chin JA, Sumpio BE. Diabetes Mellitus and Peripheral Vascular Disease Diagnosis and Management. Clinics In Podiatric Medicine And Surgery 2013, 31: 11-26. PMID: 24296015, DOI: 10.1016/j.cpm.2013.09.001.Peer-Reviewed Original ResearchConceptsPeripheral artery diseasePhysical examination findingsDifferent diagnostic modalitiesArtery diseaseDiabetes mellitusExamination findingsEndovascular interventionTreatment modalitiesDiagnostic modalitiesPathologic basisSame patientPrevalent diseaseVascular disease diagnosisNoninvasive studiesDiseaseMellitusDiagnosisModalitiesDisease diagnosisPatientsManagementClinical implications of the angiosome model in peripheral vascular disease
Sumpio BE, Forsythe RO, Ziegler KR, van Baal JG, Lepantalo MJ, Hinchliffe RJ. Clinical implications of the angiosome model in peripheral vascular disease. Journal Of Vascular Surgery 2013, 58: 814-826. PMID: 23972249, DOI: 10.1016/j.jvs.2013.06.056.Peer-Reviewed Original ResearchConceptsPeripheral vascular diseaseVascular diseaseAngiosome modelVascular surgeryCritical limb ischemiaLarger patient populationReperfusion strategyProspective trialRevascularization attemptsSuccessful revascularizationLimb ischemiaSecondary amputationProspective studyFluorescent angiographyPatient populationVascular operationsAngiosome conceptEndovascular proceduresUnhealed woundsSystematic reviewClinical implicationsDiseaseSurgeryCurrent literatureSignificant rate
2011
The role of mechanical forces and adenosine in the regulation of intestinal enterochromaffin cell serotonin secretion
Chin A, Svejda B, Gustafsson B, Granlund A, Sandvik A, Timberlake A, Sumpio B, Pfragner R, Modlin I, Kidd M. The role of mechanical forces and adenosine in the regulation of intestinal enterochromaffin cell serotonin secretion. AJP Gastrointestinal And Liver Physiology 2011, 302: g397-g405. PMID: 22038827, PMCID: PMC3287403, DOI: 10.1152/ajpgi.00087.2011.Peer-Reviewed Original ResearchMeSH KeywordsAcetamidesAdenosineAdenosine A2 Receptor AgonistsAdenosine A2 Receptor AntagonistsAdenosine-5'-(N-ethylcarboxamide)AdultAgedCell Line, TumorCells, CulturedColonCrohn DiseaseCyclic AMPCyclic AMP Response Element-Binding ProteinCyclic AMP-Dependent Protein KinasesEnterochromaffin CellsFemaleGene ExpressionHumansMaleMAP Kinase Kinase 1MAP Kinase Signaling SystemMechanotransduction, CellularMiddle AgedPhosphorylationProto-Oncogene Proteins c-aktPurinesReceptor, Adenosine A1Receptor, Adenosine A2AReceptor, Adenosine A2BReceptor, Adenosine A3SerotoninSignal TransductionStress, MechanicalTryptophan HydroxylaseVesicular Monoamine Transport ProteinsConceptsInflammatory bowel diseaseEC cellsCell functionEC cell functionMechanical stimulationDevelopment of agentsSecrete serotoninBowel diseaseIntracellular cAMP levelsGut motilityEnterochromaffin cellsAdenosine responsivenessReceptor agonistReceptor expressionHuman EC cellsSerotonin secretionAdenosine receptorsMRS1754CAMP productionSecretionCAMP levelsNECANeoplasiaMechanosensory cellsDiseaseCardiovascular disease: the new epidemic in sub-Saharan Africa
Ikem I, Sumpio BE. Cardiovascular disease: the new epidemic in sub-Saharan Africa. Vascular 2011, 19: 301-307. PMID: 21940758, DOI: 10.1258/vasc.2011.ra0049.Peer-Reviewed Original ResearchConceptsCVD risk factorsRisk factorsCurrent human immunodeficiency virus (HIV) epidemicHuman immunodeficiency virus (HIV) epidemicDouble burdenNew epidemicCardiovascular disease preventionCoronary heart diseasePrevalence of CVDCause of deathNon-communicable diseasesHIV/CVD deathImmunodeficiency syndromeCVD diseaseEpidemiological shiftHeart diseaseSmoking ratesDisease preventionCurrent epidemicDiseaseVirus epidemicDiabetesEpidemicHigh rate
2010
The critical role of hemodynamics in the development of cerebral vascular disease.
Nixon AM, Gunel M, Sumpio BE. The critical role of hemodynamics in the development of cerebral vascular disease. Journal Of Neurosurgery 2010, 112: 1240-53. PMID: 19943737, DOI: 10.3171/2009.10.jns09759.Peer-Reviewed Original ResearchConceptsCerebral vascular diseaseVascular diseaseUnique hemodynamic conditionsExtracranial atherosclerosisArtery diseaseIntracranial atherosclerosisIntracranial saccular aneurysmsTreatment optionsVascular disordersHemodynamic parametersAneurysm formationSaccular aneurysmHemodynamic conditionsNormal levelsVascular biologyDiseaseMultiple studiesMore studiesPatient-specific dataAtherosclerosisHemodynamicsMagnitude of WSSRiskLow wall shear stressDisorders
2009
Polyphenols are medicine: Is it time to prescribe red wine for our patients?
Cordova A, Sumpio B. Polyphenols are medicine: Is it time to prescribe red wine for our patients? International Journal Of Angiology 2009, 18: 111-117. PMID: 22477510, PMCID: PMC2903024, DOI: 10.1055/s-0031-1278336.Peer-Reviewed Original ResearchLow physical activityNumerous epidemiological studiesVascular diseaseRisk factorsCardiovascular diseaseChronic pathologiesPhysical activityEpidemiological studiesModerate consumptionElevated smokingFrench paradoxRed wineHigh consumptionDiseaseHigh levelsPolyphenolsSmokingPatientsCancerMortalityPathologyPrevention31 The Role of Gastrointestinal Mechanical Forces in the Regulation of Gut Enterochromaffin Cell Secretion and the Implications for Irritable Bowel Disease
Kidd M, Chin A, Gustafsson B, Siddique Z, Drozdov I, Sumpio B, Pfragner R, Modlin I. 31 The Role of Gastrointestinal Mechanical Forces in the Regulation of Gut Enterochromaffin Cell Secretion and the Implications for Irritable Bowel Disease. Gastroenterology 2009, 136: a-4. DOI: 10.1016/s0016-5085(09)60022-6.Peer-Reviewed Original Research
2007
Predictors for the Healing of Transmetatarsal Amputations: Retrospective Study of 91 Amputations
Blume P, Salonga C, Garbalosa J, Pierre-Paul D, Key J, Gahtan V, Sumpio BE. Predictors for the Healing of Transmetatarsal Amputations: Retrospective Study of 91 Amputations. Vascular 2007, 15: 126-133. PMID: 17573017, DOI: 10.2310/6670.2007.00035.Peer-Reviewed Original ResearchCryosurgery: A review
Yiu W, Basco M, Aruny J, Cheng S, Sumpio B. Cryosurgery: A review. International Journal Of Angiology 2007, 16: 1-6. PMID: 22477240, PMCID: PMC2732998, DOI: 10.1055/s-0031-1278235.Peer-Reviewed Original ResearchUse of cryotherapyDifferent clinical situationsUse of cryosurgeryPain controlSurgical resectionLow morbidityBronchial cancerProstate diseaseSafe techniqueTissue destructionLocalized lesionsClinical situationsCryosurgical techniquesLocal applicationDisease responseCryosurgeryClinical applicationFreeze injuryMorbidityResectionCryotherapyInjuryLesionsCancerDisease
2000
Diabetic foot disease
Knox R, Dutch W, Blume P, Sumpio B. Diabetic foot disease. International Journal Of Angiology 2000, 9: 1-6. PMID: 10629315, DOI: 10.1007/bf01616320.Peer-Reviewed Original ResearchVASCULAR ASSESSMENT
Collins K, Sumpio B. VASCULAR ASSESSMENT. Clinics In Podiatric Medicine And Surgery 2000, 17: 171-191. PMID: 10810651, DOI: 10.1016/s0891-8422(23)01121-7.Peer-Reviewed Original ResearchConceptsVascular testingClinical syndromePeripheral vascular diseaseDistinct clinical syndromeNoninvasive vascular laboratoryGrade lesionsSurgical interventionVascular assessmentVascular statusAdjunctive usePhysical examinationThorough historyVascular diseasePeripheral vasculatureVascular laboratoryContrast angiographyClinical scenariosInvasive methodPatientsSyndromeInterventionAngiographyLesionsDiseaseTestingAcute Mesenteric Ischemia
Sai Sudhakar C, Pollock J, Sumpio B. Acute Mesenteric Ischemia. 2000, 559-571. DOI: 10.1007/978-1-4612-1190-7_46.Peer-Reviewed Original ResearchAcute mesenteric ischemiaMesenteric ischemiaMortality rateAcute abdominal painHigh mortality rateDefinitive diagnostic methodAbdominal painSignificant morbidityAbdominal diseasePatient referralIntestinal disordersDiffuse symptomsEarly diagnosisIschemiaDiagnostic methodsMorbidityPainPatientsHospitalReferralSymptomsDiseaseDiagnosisDiabetic foot disease
Knox R, Dutch W, Blume P, Sumpio B. Diabetic foot disease. International Journal Of Angiology 2000, 1-6. DOI: 10.1055/s-0031-1276208.Peer-Reviewed Original Research
1999
Localization of Atherosclerosis: Role of Hemodynamics
Frangos S, Gahtan V, Sumpio B. Localization of Atherosclerosis: Role of Hemodynamics. JAMA Surgery 1999, 134: 1142-1149. PMID: 10522862, DOI: 10.1001/archsurg.134.10.1142.Peer-Reviewed Original ResearchConceptsEndothelial cell structureCoronary arteryAortic archRisk factorsAbdominal aortaChronic diseasesVascular endotheliumCircumferential strainRole of hemodynamicsLesionsHemodynamic forcesCyclic circumferential strainMajor branchesSusceptible sitesAtherosclerosisArteryAortaHemodynamicsAtherogenesisEndotheliumDisease
1996
Quantitative blood flow measurements with cine phase-contrast MR imaging of subjects at rest and after exercise to assess peripheral vascular disease.
Pena C, McCauley T, Price T, Sumpio B, Gusberg R, Gore J. Quantitative blood flow measurements with cine phase-contrast MR imaging of subjects at rest and after exercise to assess peripheral vascular disease. American Journal Of Roentgenology 1996, 167: 153-7. PMID: 8659362, DOI: 10.2214/ajr.167.1.8659362.Peer-Reviewed Original ResearchConceptsPeripheral vascular diseaseAnkle-brachial indexAbnormal ankle-brachial indexVascular diseaseVolume blood flowBlood flow measurementsBlood flowCine phase-contrast MR imagingLarger patient groupsPhase-contrast MR imagingPlantar flexion exerciseOlder normal volunteersVolume blood flow measurementsPopliteal arteryPatient groupFlexion exerciseNormal volunteersPatientsTriphasic waveformQuantitative blood flow measurementsFlow increasesMR imagingDiseaseVolunteersSimilar age