2012
Diabetic Foot Ulceration and Management
Blume P, Jain A, Sumpio B. Diabetic Foot Ulceration and Management. Contemporary Diabetes 2012, 63-91. DOI: 10.1007/978-1-62703-158-5_6.Peer-Reviewed Original ResearchFoot ulcersMajor public health issueGrowth factorDiabetic foot diseaseDiabetic foot ulcerationHospitalization of patientsGood clinical careTreatment of infectionsMoist wound carePublic health issueComplex clinical problemWidespread clinical practiceAbnormal foot structureAdjuvant therapySuperimposed infectionFoot ulcerationFrequent debridementLimb salvagePathophysiologic mechanismsChronic inflammationDiabetic footCostly complicationFoot problemsIschemic limbsClinical trials
2010
The Semmes Weinstein monofilament examination is a significant predictor of the risk of foot ulceration and amputation in patients with diabetes mellitus
Feng Y, Schlösser FJ, Sumpio BE. The Semmes Weinstein monofilament examination is a significant predictor of the risk of foot ulceration and amputation in patients with diabetes mellitus. Journal Of Vascular Surgery 2010, 53: 220-226.e5. PMID: 20692793, DOI: 10.1016/j.jvs.2010.06.100.Peer-Reviewed Original ResearchConceptsSemmes-Weinstein monofilament examinationLower extremity amputationDiabetes mellitusFoot ulcerationRelative riskMonofilament examinationDiabetic footPrognostic valueRisk of LEADiabetic peripheral neuropathyMEDLINE/PubMed databasePrognosis of patientsDiabetic foot ulcerationPublication date restrictionsEvidence-based toolsIndependent predictorsMajor complicationsPeripheral neuropathyPatient selectionExtremity amputationAbsolute riskDate restrictionsPrognostic studiesCurrent evidenceUlceration
2003
Charcot Joint Disease in Diabetes Mellitus
Lee L, Blume PA, Sumpio B. Charcot Joint Disease in Diabetes Mellitus. Annals Of Vascular Surgery 2003, 17: 571-580. PMID: 14508661, DOI: 10.1007/s10016-003-0039-5.Peer-Reviewed Original ResearchConceptsCharcot joint diseaseDiabetes mellitusJoint diseaseCharcot neuropathic arthropathyDiabetic foot ulcerationStructural foot deformitiesDevastating deformitiesNeuropathic arthropathyCharcot arthropathyDiabetic patientsFoot ulcerationClinical presentationDegenerative arthropathyPedal ulcerationFoot deformityFoot problemsTreatment modalitiesImmediate treatmentVascular surgeonsNeuropathic diseasePatientsMellitusArthropathyEarly signsStructural deformity
1998
Antiproliferative effect of elevated glucose in human microvascular endothelial cells
Kamal K, Du W, Mills I, Sumpio B. Antiproliferative effect of elevated glucose in human microvascular endothelial cells. Journal Of Cellular Biochemistry 1998, 71: 491-501. PMID: 9827695, DOI: 10.1002/(sici)1097-4644(19981215)71:4<491::aid-jcb4>3.0.co;2-p.Peer-Reviewed Original ResearchConceptsMicrovascular endothelial cellsElevated glucoseHMEC-1Endothelial cellsAntiproliferative effectsDiabetic microangiopathyDiabetic foot ulcerationHuman dermal microvascular endothelial cellsCyclic AMP accumulationMicrovascular endothelial cell lineDermal microvascular endothelial cellsHuman microvascular endothelial cellsImmortalized human dermal microvascular endothelial cell lineHigh D-glucoseDeleterious effectsHuman dermal microvascular endothelial cell linePrimary cultured cellsEndothelial cell lineFoot ulcerationHMEC-1 proliferationProliferative responseAMP accumulationPathological complicationsMolecular pathophysiologyRp-cAMPS