Madeline Mayday
About
Research
Publications
2025
Upper and Lower Respiratory Tract Compartmentalization in Pediatric Stem Cell Transplantation
Evans EM, Mayday MY, Pearce EM, Iwanaga K, Ly N, Church G, Reyes G, Simon MR, Blum J, Kim H, Mu J, Baez-Maidana J, Auletta JJ, Shaw PJ, Kreml EM, Martin PL, Duncan CN, Rowan CM, Godder K, Hurley C, Cuvelier GD, Qayed M, Abdel-Azim H, Keating AK, Fitzgerald JC, Hanna R, Killinger JS, Hume JR, Quigg TC, Castillo P, Satwani P, Moore TB, Dvorak CC, Zinter MS. Upper and Lower Respiratory Tract Compartmentalization in Pediatric Stem Cell Transplantation. 2025 DOI: 10.1101/2025.10.15.25336763.Peer-Reviewed Original ResearchRBM15-MKL1 fusion protein promotes leukemia via m6A methylation and Wnt pathway activation
Mayday M, Biancon G, Wei M, Ramirez C, Moratti I, Pintado-Urbanc A, Espinosa J, Chen M, Wang L, Simon M, Ofir-Rosenfeld Y, Rausch O, Tebaldi T, Halene S, Krause D. RBM15-MKL1 fusion protein promotes leukemia via m6A methylation and Wnt pathway activation. Blood 2025, 146: 1096-1109. PMID: 40435410, PMCID: PMC12783520, DOI: 10.1182/blood.2024027712.Peer-Reviewed Original ResearchRNA fateM6A modificationFusion proteinWnt pathway activationFrizzled genesFunctions of RBM15Dysregulation of m6A modificationRBM15-MKL1Pathway activationMulti-omics approachInduced apoptosis in vitroWnt Signaling PathwayApoptosis in vitroM6A depositionRNA bindingSpecific RNAGrowth in vitroM6A methylationMRNA targetsSignaling pathwayWnt pathwayWnt signalingM6A modifiersM6A-dependent mechanismRNAIntegrating pulmonary and systemic transcriptomes to characterize lung injury after pediatric hematopoietic stem cell transplant.
Pearce EM, Evans E, Mayday MY, Reyes G, Simon MR, Blum J, Kim H, Mu J, Shaw PJ, Rowan CM, Auletta JJ, Martin PL, Hurley C, Kreml EM, Qayed M, Abdel-Azim H, Keating AK, Cuvelier G, Hume JR, Killinger JS, Godder K, Hanna R, Duncan CN, Quigg TC, Castillo P, Lalefar NR, Fitzgerald JC, Mahadeo KM, Satwani P, Moore TB, Hanisch B, Abdel-Mageed A, Davis DB, Hudspeth MP, Yanik GA, Pulsipher MA, Dvorak CC, DeRisi JL, Zinter MS. Integrating pulmonary and systemic transcriptomes to characterize lung injury after pediatric hematopoietic stem cell transplant. JCI Insight 2025, 10 PMID: 40694427, DOI: 10.1172/jci.insight.194440.Peer-Reviewed Original ResearchCanonical nuclear envelope protein emerin regulates structure and integrity of the erythrocyte plasma membrane
O’Brien BJ, Oliver J, Thompson E, Mayday MY, Mancuso R, Jha A, Kwan J, Bonne G, Ben Yaou R, Leturcq F, Bai S, Nottoli T, Hwa J, Krause DS, Gallagher PG, Gu SX, Martin KA. Canonical nuclear envelope protein emerin regulates structure and integrity of the erythrocyte plasma membrane. 2025 DOI: 10.1101/2025.06.06.658339.Peer-Reviewed Original Research
2024
Pathobiological signatures of dysbiotic lung injury in pediatric patients undergoing stem cell transplantation.
Zinter MS, Dvorak CC, Mayday MY, Reyes G, Simon MR, Pearce EM, Kim H, Shaw PJ, Rowan CM, Auletta JJ, Martin PL, Godder K, Duncan CN, Lalefar NR, Kreml EM, Hume JR, Abdel-Azim H, Hurley C, Cuvelier GDE, Keating AK, Qayed M, Killinger JS, Fitzgerald JC, Hanna R, Mahadeo KM, Quigg TC, Satwani P, Castillo P, Gertz SJ, Moore TB, Hanisch B, Abdel-Mageed A, Phelan R, Davis DB, Hudspeth MP, Yanik GA, Pulsipher MA, Sulaiman I, Segal LN, Versluys BA, Lindemans CA, Boelens JJ, DeRisi JL, Pediatric Transplantation and Cell Therapy Consortium. Pathobiological signatures of dysbiotic lung injury in pediatric patients undergoing stem cell transplantation. Nat Med 2024 PMID: 38783139, DOI: 10.1038/s41591-024-02999-4.Peer-Reviewed Original Research
2023
Pulmonary microbiome and transcriptome signatures reveal distinct pathobiologic states associated with mortality in two cohorts of pediatric stem cell transplant patients.
Zinter MS, Dvorak CC, Mayday MY, Reyes G, Simon MR, Pearce EM, Kim H, Shaw PJ, Rowan CM, Auletta JJ, Martin PL, Godder K, Duncan CN, Lalefar NR, Kreml EM, Hume JR, Abdel-Azim H, Hurley C, Cuvelier GDE, Keating AK, Qayed M, Killinger JS, Fitzgerald JC, Hanna R, Mahadeo KM, Quigg TC, Satwani P, Castillo P, Gertz SJ, Moore TB, Hanisch B, Abdel-Mageed A, Phelan R, Davis DB, Hudspeth MP, Yanik GA, Pulsipher MA, Sulaiman I, Segal LN, Versluys BA, Lindemans CA, Boelens JJ, DeRisi JL, Pediatric Transplantation and Cell Therapy Consortium. Pulmonary microbiome and transcriptome signatures reveal distinct pathobiologic states associated with mortality in two cohorts of pediatric stem cell transplant patients. MedRxiv 2023 PMID: 38077035, DOI: 10.1101/2023.11.29.23299130.Peer-Reviewed Original Research
2022
Multiparameter analysis of timelapse imaging reveals kinetics of megakaryocytic erythroid progenitor clonal expansion and differentiation
Scanlon VM, Thompson EN, Lawton BR, Kochugaeva M, Ta K, Mayday MY, Xavier-Ferrucio J, Kang E, Eskow NM, Lu YC, Kwon N, Laumas A, Cenci M, Lawrence K, Barden K, Larsuel ST, Reed FE, Peña-Carmona G, Ubbelohde A, Lee JP, Boobalan S, Oppong Y, Anderson R, Maynard C, Sahirul K, Lajeune C, Ivathraya V, Addy T, Sanchez P, Holbrook C, Van Ho AT, Duncan JS, Blau HM, Levchenko A, Krause DS. Multiparameter analysis of timelapse imaging reveals kinetics of megakaryocytic erythroid progenitor clonal expansion and differentiation. Scientific Reports 2022, 12: 16218. PMID: 36171423, PMCID: PMC9519589, DOI: 10.1038/s41598-022-19013-x.Peer-Reviewed Original ResearchConceptsMegakaryocytic-erythroid progenitorsFate specificationLineage commitmentUnderstanding of hematopoiesisProgenitor cell biologyPrimary human hematopoietic progenitorsSingle-cell trackingSingle-cell assaysSingle-cell levelHuman hematopoietic progenitorsProgenitor cell dynamicsLineage specificationCell fateColony-forming unit assaysTimelapse imagingSitu fluorescence stainingCell biologyLineage tracingDivision rateCytokine thrombopoietinHematopoietic progenitorsProgenitorsFluorescence stainingCell dynamicsUnit assaysPulmonary microbiome and gene expression signatures differentiate lung function in pediatric hematopoietic cell transplant candidates.
Zinter MS, Versluys AB, Lindemans CA, Mayday MY, Reyes G, Sunshine S, Chan M, Fiorino EK, Cancio M, Prevaes S, Sirota M, Matthay MA, Kharbanda S, Dvorak CC, Boelens JJ, DeRisi JL. Pulmonary microbiome and gene expression signatures differentiate lung function in pediatric hematopoietic cell transplant candidates. Science Translational Medicine 2022, 14: eabm8646. PMID: 35263147, DOI: 10.1126/scitranslmed.abm8646.Peer-Reviewed Original Research
2021
MRTFA: A critical protein in normal and malignant hematopoiesis and beyond
Reed F, Larsuel ST, Mayday MY, Scanlon V, Krause DS. MRTFA: A critical protein in normal and malignant hematopoiesis and beyond. Journal Of Biological Chemistry 2021, 296: 100543. PMID: 33722605, PMCID: PMC8079280, DOI: 10.1016/j.jbc.2021.100543.Peer-Reviewed Original ResearchConceptsMalignant hematopoiesisActin cytoskeleton dynamicsCritical cellular functionsResponse factorSerum response factorTranscription factor ACellular rolesImmediate early genesProtein partnersTranscriptional regulationCytoskeleton dynamicsCellular functionsTranscriptional targetsTranscription factorsCytoskeletal proteinsCritical proteinsMRTFAEarly genesCell typesChromosomal translocationsHematopoietic cellsCell growthFactor AHematopoiesisMuscle cells
2020
The Pulmonary Metatranscriptome Prior to Pediatric Hematopoietic Cell Transplantation Identifies Post-HCT Lung Injury
Zinter MS, Lindemans C, Versluys B, Mayday MY, Sunshine S, Reyes G, Sirota M, Sapru A, Matthay MA, Kharbanda S, Dvorak CC, Boelens J, DeRisi JL. The Pulmonary Metatranscriptome Prior to Pediatric Hematopoietic Cell Transplantation Identifies Post-HCT Lung Injury. Blood 2020, 137: 1679-1689. PMID: 33512420, PMCID: PMC7995292, DOI: 10.1182/blood.2020009246.Peer-Reviewed Original ResearchConceptsHematopoietic cell transplantationLung injuryHCT candidatesBronchoalveolar lavagePediatric allogeneic hematopoietic cell transplantationAllogeneic hematopoietic cell transplantationRespiratory viral loadUniversity Medical Center UtrechtInnate immune activationPulmonary gene expressionLong-term survivalSeparate validation cohortT cell activationCumulative incidenceBAL fluidViral loadDisastrous complicationImmune activationValidation cohortCell transplantationLung healthMucus productionHigh incidenceIndependent cohortInjury
Academic Achievements & Community Involvement
News
News
- August 28, 2025
Yale Study: Potential Treatment Pathway Found for Rare and Aggressive Leukemia
- October 18, 2023
Yale Pathology Graduate Students Receive Prestigious NIH F31 Awards
- September 20, 2022
ExPath Grad Student Madeline Mayday Awarded Grant from the NIDDK Cooperative Centers of Excellence in Hematology