Nii Addy, PhD
Cards
Contact/Administration
About
Contact/Administration
About
Contact/Administration
Contact Info
Administrative Support
Titles
Albert E. Kent Associate Professor of Psychiatry and Associate Professor of Cellular and Molecular Physiology
Director of Faculty Development and Collaborative Excellence, YSM Office of Collaborative Excellence
Appointments
Contact Info
Administrative Support
Titles
Albert E. Kent Associate Professor of Psychiatry and Associate Professor of Cellular and Molecular Physiology
Director of Faculty Development and Collaborative Excellence, YSM Office of Collaborative Excellence
Appointments
Contact Info
Administrative Support
About
Titles
Albert E. Kent Associate Professor of Psychiatry and Associate Professor of Cellular and Molecular Physiology
Director of Faculty Development and Collaborative Excellence, YSM Office of Collaborative Excellence
Biography
Nii Addy is the Albert E. Kent Associate Professor of Psychiatry and Associate Professor of Cellular and Molecular Physiology and the Director of Faculty Development and Collaborative Excellence. He is also Director of the Faculty Mentoring Program for the Minority Organization for Retention and Expansion (MORE) and former co-chair of the Career Development Subcommittee of the ARCH Task Force in the Yale Department of Psychiatry. He contributes to graduate student and postdoctoral training and to mentorship and sponsorship initiatives through his efforts on campus and in scientific societies.
He received his B.S. in Biology from Duke University and his Ph.D. in Neuroscience from Yale University. Dr. Addy directs a federally funded research program investigating cholinergic, dopaminergic and L-type calcium channel mechanisms mediating substance use and mood disorders. Dr. Addy’s team also studies the ability of tobacco product flavor additives to alter nicotine use behavior and addiction. He serves on the journal editorial board of Neuropsychopharmacology, Biological Psychiatry, and Neuropharmacology, and he previously served as a grant reviewer for the Neurobiology of Motivated Behavior (NMB) Study Section of the National Institutes of Health's Center for Scientific Review (CSR).
In addition to his campus work, Dr. Addy hosts the Addy Hour podcast, discussing topics at the intersection of neuroscience, mental health, faith, and culture. Episodes include dynamic conversations based on the lived experience and professional expertise of his guests - which include community leaders, clinicians and mental health experts, scientists, professional athletes and entertainers, faith leaders, and mental health advocates. As the creator and host of town hall community events, Dr. Addy has also built unique partnerships to encourage and equip audiences to embrace the use of holistic, integrated tools to address mental health challenges. He has collaborated with Lecrae (Grammy Award-winning artist and NY Times Best Seller), Doug Middleton (Jacksonville Jaguars/ Dream the Impossible Initiative), Allan Houston (former NBA All-Star, NY Knicks/ FISLL Project), the National Alliance on Mental Illness (NAMI), the Veritas Forum, the Anxiety and Depression Association of America (ADAA), the Association for Behavioral and Cognitive Therapies (ABCT), the Yale University Chaplain's Office, Yale Well, the Salvation Army, Every Nation Church NYC, the American Bible Society and others. His research and community work have been featured by National Public Radio (NPR), Newsday, the National Football League Players Association (NFLPA), The Source Magazine, Chuck Norris, BoldTV, Legitimate Matters, and Relevant Magazine. He has presented scientific lectures at universities throughout the United States and Europe, and he serves on the Board of Trustees for The Carver Project, aimed at empowering and connecting individuals across university, church and society.
Appointments
Psychiatry
Associate Professor on TermPrimaryCellular & Molecular Physiology
Associate Professor on TermSecondary
Other Departments & Organizations
- Abraham Ribicoff Research Facilities
- Addy Lab
- Cellular & Molecular Physiology
- Connecticut Mental Health Center
- Division of Molecular Psychiatry
- Interdepartmental Neuroscience Program
- Molecular Medicine, Pharmacology, and Physiology
- MORE
- Neuroscience Research Training Program (NRTP)
- Neuroscience Track
- Psychiatry
- Wu Tsai Institute
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
- Yale Tobacco Center of Regulatory Science
- Yale Ventures
- YSM Office of Collaborative Excellence
Education & Training
- PhD
- Yale University (2007)
- BS
- Duke University (2000)
Research
Overview
Medical Research Interests
ORCID
0000-0002-9321-6067- View Lab Website
Addy Lab at Yale
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Eric Nunes, PhD
Deniz Bagdas, DVM, PhD
Ayana Jordan, MD, PhD
John Krystal, MD
Marina Picciotto, PhD
Yusuf Ransome, MPH, DrPH
Signal Transduction
Substance-Related Disorders
Electrochemistry
Publications
2025
L-type calcium channel blockade attenuates cue-induced cocaine-seeking in female rats
Kimble V, Nunes E, Rajadhyaksha A, Addy N. L-type calcium channel blockade attenuates cue-induced cocaine-seeking in female rats. Behavioural Brain Research 2025, 490: 115613. PMID: 40324598, PMCID: PMC12145892, DOI: 10.1016/j.bbr.2025.115613.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsCue-induced cocaine-seekingCocaine-seekingL-type calcium channelsExposure to drug-associated cuesPeriods of cocaine abstinenceCocaine-associated cuesCue-induced relapseCocaine self-administrationCocaine-dependent individualsCocaine-seeking behaviorDrug-associated cuesDrug-seeking behaviorCocaine-takingCocaine abstinenceSex-specific mechanismsSelf-administrationRelapse preventionAbstinence periodAddiction treatmentAdministration of isradipineRisk of relapseAbstinenceL-type calcium channel blockadeRelapse riskFemale ratsEffects of Sweeteners and Cinnamon Flavor on Oral Nicotine Choice Behaviors
Bagdas D, Sedaille J, Khan M, Okpala N, Addy N. Effects of Sweeteners and Cinnamon Flavor on Oral Nicotine Choice Behaviors. Nicotine & Tobacco Research 2025, ntaf037. PMID: 40097606, DOI: 10.1093/ntr/ntaf037.Peer-Reviewed Original ResearchCitationsAltmetricConceptsOral nicotine productsNicotine preferenceFemale adult Sprague-Dawley ratsBitter solutionsAdult Sprague-Dawley ratsNicotine delivery methodsChoice behaviorSprague-Dawley ratsDose-response analysisEvidence-based guidelinesTested nicotineNicotine solutionInfluence addictionSweet solutionsPresence of sweetenersBehavioral studiesNicotineSaccharinNicotine productsHarm reduction strategiesCombination of cinnamaldehydeRatsDifferential preferenceDelivery methodsMaleWorkplace bullying among medical laboratory professionals in Ghana: insights from self-reported experiences, challenges to mitigation structures, and coping strategies
Duah E, Ephraim R, Kotam G, Kumordzi S, Amoah S, Addy N, Kwashie S, Rahamani A. Workplace bullying among medical laboratory professionals in Ghana: insights from self-reported experiences, challenges to mitigation structures, and coping strategies. BMC Health Services Research 2025, 25: 310. PMID: 40001166, PMCID: PMC11853304, DOI: 10.1186/s12913-025-12458-6.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsMedical laboratory professionalsLaboratory professionalsPatient careConfidence intervalsCross-sectional surveyRevised Negative Acts QuestionnaireSelf-reported experiencesBackgroundWorkplace bullyingNegative Acts QuestionnaireConclusionThe high prevalenceWorkplace bullyingHealthcare professionalsUrban counterpartsBachelor's degree holdersDegree holdersHigher oddsNAQ-RCoping strategiesOdds ratioRural professionalsActs QuestionnaireLogistic regressionDemographic informationProfessionalsWorkplace characteristicsIMPACT OF VANILLA FLAVOR ON NICOTINE TASTE, INTAKE, AND SEEKING BEHAVIORS
Bagdas D, Z. A, Harris L, Minanov K, Jimenez J, Addy N. IMPACT OF VANILLA FLAVOR ON NICOTINE TASTE, INTAKE, AND SEEKING BEHAVIORS. Drug And Alcohol Dependence 2025, 267: 112317. DOI: 10.1016/j.drugalcdep.2024.112317.Peer-Reviewed Original ResearchL-type calcium channel blockade attenuates the anxiogenic-like effects of cocaine abstinence in female and male rats
Nunes E, Kimble V, Rajadhyaksha A, Addy N. L-type calcium channel blockade attenuates the anxiogenic-like effects of cocaine abstinence in female and male rats. Neuroscience 2025, 568: 314-322. PMID: 39761823, DOI: 10.1016/j.neuroscience.2025.01.003.Peer-Reviewed Original ResearchThis study found that isradipine reduces anxiety and depression-like symptoms during cocaine withdrawal in rats, suggesting potential treatment for mood disorders in addiction.
2024
Preclinical Evidence of the Effects of Sweet Flavors: Sweetness Increases Nicotine Intake and Seeking
Bagdas D, Addy N. Preclinical Evidence of the Effects of Sweet Flavors: Sweetness Increases Nicotine Intake and Seeking. Nicotine & Tobacco Research 2024, 27: 666-675. PMID: 39413033, PMCID: PMC11931221, DOI: 10.1093/ntr/ntae241.Peer-Reviewed Original ResearchCitationsConceptsNicotine use behaviorsNicotine reinforcementNicotine intakeSelf-administrationNicotine useFlavor exposureUse behaviorsIntravenous nicotine self-administrationPattern of nicotine intakeSessions of self-administrationNicotine self-administrationIncreased nicotine intakeNicotine-related behaviorsSaccharin-flavored solutionInfluence of early exposureSeeking behaviorNo significant sex differencesSignificant sex differencesImpact of early exposureSaccharin exposureEarly exposureFlavored solutionNicotine addictionSex differencesNicotineL-type calcium channel regulation of depression, anxiety and anhedonia-related behavioral phenotypes following chronic stress exposure
Nunes E, Kebede N, Rajadhyaksha A, Addy N. L-type calcium channel regulation of depression, anxiety and anhedonia-related behavioral phenotypes following chronic stress exposure. Neuropharmacology 2024, 257: 110031. PMID: 38871116, PMCID: PMC11334593, DOI: 10.1016/j.neuropharm.2024.110031.Peer-Reviewed Original ResearchCitationsConceptsChronic unpredictable stressHome cage controlsElevated plus mazeForced swim testSucrose preference testCUS-induced decreaseChronic stress exposureImmobility timeStress exposureL-type calcium channelsDays of chronic unpredictable stressAnxiogenic-like behavioral responsesForced swim test immobility timeBehavioral responsesPre-existing mental health challengesAntidepressant-like responseOpen arm timeMood-related disordersRegulation of depressionExposure to chronic stressorsMale ratsL-type calcium channel blocker isradipineArm timePlus mazeSucrose preferenceImpact of vanilla flavor on nicotine taste, choice, intake, and seeking behaviors
Bagdas D, Zepei A, Harris L, Minanov K, Jimenez J, Addy N. Impact of vanilla flavor on nicotine taste, choice, intake, and seeking behaviors. Psychopharmacology 2024, 241: 2241-2253. PMID: 38839631, PMCID: PMC11836642, DOI: 10.1007/s00213-024-06630-9.Peer-Reviewed Original ResearchCitationsConceptsTaste reactivity testNicotine choiceNicotine takingTwo-bottle free choice testSeeking behaviorOral nicotine intakeNicotine preferenceFree-choice testNicotine intakeIngestive responsesOral nicotineDecreased dislikeAversive responsesOral cuesYoung adult Sprague Dawley ratsOrosensory propertiesAdult Sprague Dawley ratsIncreased likingNicotineFemale ratsMale ratsSprague Dawley ratsTobacco productsLong-term effectsDawley ratsThe Biological Psychiatry Cover Art Initiative: Addressing the Underrepresentation of Black People on the Journal Cover Through a Series of Commissioned Artworks
Krystal J, Addy N, Imeh I. The Biological Psychiatry Cover Art Initiative: Addressing the Underrepresentation of Black People on the Journal Cover Through a Series of Commissioned Artworks. Biological Psychiatry 2024, 95: s26. DOI: 10.1016/j.biopsych.2024.02.068.Peer-Reviewed Original ResearchThe impact of racism on Black American mental health
Cogburn C, Roberts S, Ransome Y, Addy N, Hansen H, Jordan A. The impact of racism on Black American mental health. The Lancet Psychiatry 2024, 11: 56-64. PMID: 38101873, DOI: 10.1016/s2215-0366(23)00361-9.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsMental illnessMental healthUnfavorable health outcomesMental health systemMental health issuesDSM-5 classification systemEpidemiological surveyHealth outcomesInadequate treatmentAmerican mental healthHealth systemExperience disparitiesHealth issuesIllnessBlack individualsBlack AmericansBlack populationHealthClassification systemMorbidityMisdiagnosisDisparities
News & Links
News
- March 24, 2025
Spicer Honored With 2025 Yale Department of Psychiatry Mental Health Advocacy Award
- June 24, 2024
“On Leadership”— A look back over the past year
- June 13, 2024
Serving by welcoming all voices
- November 13, 2023
Select speakers announced: Yale Child Study Center Grand Rounds Winter/Spring 2024