Publications

Liver lipid droplet cholesterol content is a key determinant of metabolic dysfunction–associated steatohepatitis

Sakuma I, Gaspar R, Nasiri A, Dufour S, Kahn M, Zheng J, LaMoia T, Guerra M, Taki Y, Kawashima Y, Yimlamai D, Perelis M, Vatner D, Petersen K, Huttasch M, Knebel B, Kahl S, Roden M, Samuel V, Tanaka T, Shulman G. Liver lipid droplet cholesterol content is a key determinant of metabolic dysfunction–associated steatohepatitis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2502978122. PMID: 40310463, DOI: 10.1073/pnas.2502978122.

Peer-Reviewed Original Research

Dietary oleic acid drives obesogenic adipogenesis via modulation of LXRα signaling

Wing A, Jeffery E, Church C, Goodell J, Saavedra-Peña R, Saha M, Holtrup B, Voisin M, Alavi N, Floody M, Wang Z, Zapadka T, Garabedian M, Varshney R, Rudolph M, Rodeheffer M. Dietary oleic acid drives obesogenic adipogenesis via modulation of LXRα signaling. Cell Reports 2025, 44: 115527. PMID: 40208790, DOI: 10.1016/j.celrep.2025.115527.

Peer-Reviewed Original Research

Adding insult to injury: the spectrum of tubulointerstitial responses in acute kidney injury

Baker M, Cantley L. Adding insult to injury: the spectrum of tubulointerstitial responses in acute kidney injury. Journal Of Clinical Investigation 2025, 135: e188358. PMID: 40091836, PMCID: PMC11910233, DOI: 10.1172/jci188358.

Peer-Reviewed Original Research

ATGL links insulin dysregulation to insulin resistance in adolescents with obesity and hepatosteatosis

Slusher A, Santoro N, Vash-Margita A, Galderisi A, Hu P, Tokoglu F, Li Z, Tarabra E, Strober J, Vatner D, Shulman G, Caprio S. ATGL links insulin dysregulation to insulin resistance in adolescents with obesity and hepatosteatosis. Journal Of Clinical Investigation 2025, 135: e184740. PMID: 40091831, PMCID: PMC11910223, DOI: 10.1172/jci184740.

Peer-Reviewed Original Research

Vimentin filament transport and organization revealed by single-particle tracking and 3D FIB-SEM

Renganathan B, Moore A, Yeo W, Petruncio A, Ackerman D, Weigel A, Team T, Pasolli H, Xu C, Shtengel G, Hess H, Serpinskaya A, Zhang H, Lippincott-Schwartz J, Gelfand V. Vimentin filament transport and organization revealed by single-particle tracking and 3D FIB-SEM. Journal Of Cell Biology 2025, 224: e202406054. PMID: 40062969, PMCID: PMC11893169, DOI: 10.1083/jcb.202406054.

Peer-Reviewed Original Research

Multicilia dynamically transduce Sonic Hedgehog signaling to regulate choroid plexus functions

Mao S, Song R, Jin S, Pang S, Jovanovic A, Zimmerman A, Li P, Wu X, Wendland M, Lin K, Chen W, Choksi S, Chen G, Holtzman M, Reiter J, Wan Y, Xuan Z, Xiang Y, Xu C, Upadhyayula S, Hess H, He L. Multicilia dynamically transduce Sonic Hedgehog signaling to regulate choroid plexus functions. Cell Reports 2025, 44: 115383. PMID: 40057957, DOI: 10.1016/j.celrep.2025.115383.

Peer-Reviewed Original Research

Investigation of the protein corona and biodistribution profile of polymeric nanoparticles for intra-amniotic delivery

Lynn A, Shin K, Eaton D, Rose M, Zhang X, Ene M, Grundler J, Deschenes E, Rivero R, Bracaglia L, Glazer P, Stitelman D, Saltzman W. Investigation of the protein corona and biodistribution profile of polymeric nanoparticles for intra-amniotic delivery. Biomaterials 2025, 320: 123238. PMID: 40064138, DOI: 10.1016/j.biomaterials.2025.123238.

Peer-Reviewed Original Research

The inner core enables transient touch detection in the Pacinian corpuscle

Ziolkowski L, Nikolaev Y, Chikamoto A, Oda M, Feketa V, Monedero-Alonso D, Ardasheva S, Bae S, Xu C, Pang S, Gracheva E, Bagriantsev S. The inner core enables transient touch detection in the Pacinian corpuscle. Science Advances 2025, 11: eadt4837. PMID: 40009676, PMCID: PMC11864184, DOI: 10.1126/sciadv.adt4837.

Peer-Reviewed Original Research

MeSH Keywords and Concepts

CACNA1G, A Heterotaxy Candidate Gene, Plays a Role in Ciliogenesis and Left‐Right Patterning in Xenopus tropicalis

Kostiuk V, Kabir R, Akbari R, Rushing A, González D, Kim A, Kim A, Zenisek D, Khokha M. CACNA1G, A Heterotaxy Candidate Gene, Plays a Role in Ciliogenesis and Left‐Right Patterning in Xenopus tropicalis. Genesis 2025, 63: e70009. PMID: 40008628, PMCID: PMC11867209, DOI: 10.1002/dvg.70009.

Peer-Reviewed Original Research

Suppression of endothelial ceramide de novo biosynthesis by Nogo-B contributes to cardiometabolic diseases

Rubinelli L, Manzo O, Sungho J, Del Gaudio I, Bareja R, Marino A, Palikhe S, Di Mauro V, Bucci M, Falcone D, Elemento O, Ersoy B, Diano S, Sasset L, Di Lorenzo A. Suppression of endothelial ceramide de novo biosynthesis by Nogo-B contributes to cardiometabolic diseases. Nature Communications 2025, 16: 1968. PMID: 40000621, PMCID: PMC11862206, DOI: 10.1038/s41467-025-56869-9.

Peer-Reviewed Original Research

Workplace bullying among medical laboratory professionals in Ghana: insights from self-reported experiences, challenges to mitigation structures, and coping strategies

Duah E, Ephraim R, Kotam G, Kumordzi S, Amoah S, Addy N, Kwashie S, Rahamani A. Workplace bullying among medical laboratory professionals in Ghana: insights from self-reported experiences, challenges to mitigation structures, and coping strategies. BMC Health Services Research 2025, 25: 310. PMID: 40001166, PMCID: PMC11853304, DOI: 10.1186/s12913-025-12458-6.

Peer-Reviewed Original Research

Vesicle docking and fusion pore modulation by the neuronal calcium sensor Synaptotagmin-1

Tsemperouli M, Cheppali S, Rivera-Molina F, Chetrit D, Landajuela A, Toomre D, Karatekin E. Vesicle docking and fusion pore modulation by the neuronal calcium sensor Synaptotagmin-1. Biophysical Journal 2025 PMID: 40010339, DOI: 10.1016/j.bpj.2025.02.013.

Peer-Reviewed Original Research

Optic nerve injury impairs intrinsic mechanisms underlying electrical activity in a resilient retinal ganglion cell

Zapadka T, Tran N, Demb J. Optic nerve injury impairs intrinsic mechanisms underlying electrical activity in a resilient retinal ganglion cell. The Journal Of Physiology 2025 PMID: 39985791, DOI: 10.1113/jp286414.

Peer-Reviewed Original Research

DSP-1, the major fibronectin type-II protein of donkey seminal plasma is a small heat-shock protein and exhibits chaperone-like activity against thermal and oxidative stress

Alim S, Cheppali S, Pawar S, Swamy M. DSP-1, the major fibronectin type-II protein of donkey seminal plasma is a small heat-shock protein and exhibits chaperone-like activity against thermal and oxidative stress. Biochimica Et Biophysica Acta (BBA) - Proteins And Proteomics 2025, 1873: 141064. PMID: 39956303, DOI: 10.1016/j.bbapap.2025.141064.

Peer-Reviewed Original Research

Physiologic mechanisms underlying polycystic kidney disease

Boletta A, Caplan M. Physiologic mechanisms underlying polycystic kidney disease. Physiological Reviews 2025 PMID: 39938884, DOI: 10.1152/physrev.00018.2024.

Peer-Reviewed Original Research

Molecular Components of Vesicle Cycling at the Rod Photoreceptor Ribbon Synapse

Hanke-Gogokhia C, Zapadka T, Finkelstein S, Arshavsky V, Demb J. Molecular Components of Vesicle Cycling at the Rod Photoreceptor Ribbon Synapse. Advances In Experimental Medicine And Biology 2025, 1468: 325-330. PMID: 39930217, DOI: 10.1007/978-3-031-76550-6_54.

Peer-Reviewed Original Research

Exploring Calcium Channels as Potential Therapeutic Targets in Blast Traumatic Brain Injury

Wachtler N, O’Brien R, Ehrlich B, McGuone D. Exploring Calcium Channels as Potential Therapeutic Targets in Blast Traumatic Brain Injury. Pharmaceuticals 2025, 18: 223. PMID: 40006037, PMCID: PMC11859800, DOI: 10.3390/ph18020223.

Peer-Reviewed Original Research

Engineering a genomically recoded organism with one stop codon

Grome M, Nguyen M, Moonan D, Mohler K, Gurara K, Wang S, Hemez C, Stenton B, Cao Y, Radford F, Kornaj M, Patel J, Prome M, Rogulina S, Sozanski D, Tordoff J, Rinehart J, Isaacs F. Engineering a genomically recoded organism with one stop codon. Nature 2025, 639: 512-521. PMID: 39910296, PMCID: PMC11903333, DOI: 10.1038/s41586-024-08501-x.

Peer-Reviewed Original Research

CCL21-CCR7 blockade prevents neuroinflammation and degeneration in Parkinson’s disease models

Leser F, Júnyor F, Pagnoncelli I, Delgado A, Medeiros I, Nóbrega A, Andrade B, de Lima M, da Silva N, Jacob L, Boyé K, Geraldo L, de Souza A, Maron-Gutierrez T, Castro-Faria-Neto H, Follmer C, Braga C, Neves G, Eichmann A, Romão L, Lima F. CCL21-CCR7 blockade prevents neuroinflammation and degeneration in Parkinson’s disease models. Journal Of Neuroinflammation 2025, 22: 31. PMID: 39894839, PMCID: PMC11789347, DOI: 10.1186/s12974-024-03318-x.

Peer-Reviewed Original Research

Bioengineering on the Front Lines

Tonnessen B, Dardik A. Bioengineering on the Front Lines. JAMA Surgery 2025, 160: 189-189. PMID: 39565609, DOI: 10.1001/jamasurg.2024.5137.

Peer-Reviewed Original Research

Prevalence of Food Allergy in Children with Cystic Fibrosis

Nguyen H, Whittington K, McCollum S, Shabanova V, Polk B, Lee T, Bruscia E, Egan M, Leeds S. Prevalence of Food Allergy in Children with Cystic Fibrosis. Journal Of Allergy And Clinical Immunology 2025, 155: ab41. DOI: 10.1016/j.jaci.2024.12.132.

Peer-Reviewed Original Research

T49 Effects of Nicotine Flux and Form on Speed and Total Amount of Arterial Blood Nicotine Delivery during Acute E-Cigarette Vaping

Baldassarri S, McKinney E, Mysirlidis S, Sharma M, Blohowiak R, Joseph P, Eid T, Nadim H, Hanna E, Karaoghlanian N, Adeniji A, Shihadeh A, Eissenberg T, Krishnan-Sarin S, O'Malley S, El-Hellani A, Talih S. T49 Effects of Nicotine Flux and Form on Speed and Total Amount of Arterial Blood Nicotine Delivery during Acute E-Cigarette Vaping. Drug And Alcohol Dependence 2025, 267: 111817. DOI: 10.1016/j.drugalcdep.2024.111817.

Peer-Reviewed Original Research

Concepts

BPS2025 - Conformational transition of prestin—the electro-mechanical transducer in outer hair cells of the inner ear

Zhang C, Mariadasse R, Beckstein O, Santos-Sacchi J, Navaratnam D. BPS2025 - Conformational transition of prestin—the electro-mechanical transducer in outer hair cells of the inner ear. Biophysical Journal 2025, 124: 315a. DOI: 10.1016/j.bpj.2024.11.1746.

Peer-Reviewed Original Research

Concepts

IMPACT OF VANILLA FLAVOR ON NICOTINE TASTE, INTAKE, AND SEEKING BEHAVIORS

Bagdas D, Z. A, Harris L, Minanov K, Jimenez J, Addy N. IMPACT OF VANILLA FLAVOR ON NICOTINE TASTE, INTAKE, AND SEEKING BEHAVIORS. Drug And Alcohol Dependence 2025, 267: 112317. DOI: 10.1016/j.drugalcdep.2024.112317.

Peer-Reviewed Original Research

Structural basis for human NKCC1 inhibition by loop diuretic drugs

Zho Y, Vidossich P, Forbush B, Ma J, Rinehart J, De Vivo M, Cao E. Structural basis for human NKCC1 inhibition by loop diuretic drugs. EMBO J. 2025. doi 10.1038/s44318-025-00368-6. Online January 28.

Peer-Reviewed Original Research