Yansheng Liu, PhD

Assistant Professor of Pharmacology

Departments & Organizations

Center for Biomedical Data Science

Primary Faculty

Yale Cancer Biology Institute

Yale Cancer Center: Signal Transduction

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Molecular Cell Biology, Genetics and Development | Molecular Medicine, Pharmacology, and Physiology

Yale Cancer Biology Institute

Biography

Dr. Liu received his PhD of Biomedical Sciences at Shanghai Institute for Biological Sciences, Chinese Academy of Sciences. Dr. Liu completed a post-doctoral research fellowship (May 2011 - October 2017) in the Proteomics Laboratory of Dr. Ruedi Aebersold in the Institute of Molecular Systems Biology, ETH Zurich, Switzerland. Dr. Liu joined Yale Cancer Biology Institute as an Assistant Professor of Pharmacology in December 2017. His research group at Yale aims to contribute to the development of Data independent acquisition (DIA) mass spectrometry and other proteomic techniques and their applications in Cancer Biology and Systems Biology studies. 

Education & Training

PhD Chinese Academy of sciences, Biomedical Sciences (2011)

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Contact Info

Yansheng Liu, PhD
Lab Location
Liu labWest Campus Advanced Biosciences Center
840 West Campus Drive, Fl 3rd Ste Cancer Biology Institute Rm 371A

West Haven, CT 06516
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Proteomics based on DIA MS

The next-generation proteomics, such as Data Independent Acquisition (DIA) based mass spectrometry, features the highly reproducible and precise quantification at MS2- level using signal traces presented as peak groups along liquid chromatography gradient. With such measurements, signal transduction can be profiled under various scenarios, such as steady state, long-term state changes, and short-term adaptation [1]. Questions like how protein abundance, phosphorylation, and turnover response longitudinally to different pharmacological interventions can be addressed. [1] Liu Y et al., (2016) Cell 165: 535-550