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The next-generation proteomics, such as Data Independent Acquisition (DIA) based mass spectrometry, features the highly reproducible and precise quantification at MS2- level using signal traces presented as peak groups along liquid chromatography gradient. With such measurements, signal transduction can be profiled under various scenarios, such as steady state, long-term state changes, and short-term adaptation . Questions like how protein abundance, phosphorylation, and turnover response longitudinally to different pharmacological interventions can be addressed.  Liu Y et al., (2016) Cell 165: 535-550