2008
Ethanol Exposure Depletes Hepatic Pigment Epithelium-Derived Factor, a Novel Lipid Regulator
Chung C, Shugrue C, Nagar A, Doll JA, Cornwell M, Gattu A, Kolodecik T, Pandol SJ, Gorelick F. Ethanol Exposure Depletes Hepatic Pigment Epithelium-Derived Factor, a Novel Lipid Regulator. Gastroenterology 2008, 136: 331-340.e2. PMID: 18996124, PMCID: PMC2833423, DOI: 10.1053/j.gastro.2008.09.065.Peer-Reviewed Original ResearchConceptsPigment epithelium-derived factorEthanol-induced hepatic steatosisEthanol-induced steatosisMMP-2/9 activityPEDF levelsHepatic steatosisEthanol feedingLoss of PEDFAnimal modelsTriglyceride contentRecombinant pigment epithelium-derived factorNovel lipid regulatorLiver triglyceride contentLiver biopsy specimensEpithelium-derived factorEthanol fed animalsNormal liver samplesAccumulation of lipidsHistologic steatosisBiopsy specimensClinical studiesEthanol exposureHepatocellular carcinomaSteatosisPigment epithelium
2007
Development and Physiological Regulation of Intestinal Lipid Absorption. II. Dietary lipid absorption, complex lipid synthesis, and the intracellular packaging and secretion of chylomicrons
Mansbach CM, Gorelick F. Development and Physiological Regulation of Intestinal Lipid Absorption. II. Dietary lipid absorption, complex lipid synthesis, and the intracellular packaging and secretion of chylomicrons. AJP Gastrointestinal And Liver Physiology 2007, 293: g645-g650. PMID: 17627968, DOI: 10.1152/ajpgi.00299.2007.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsChylomicronsDietary FatsEndoplasmic ReticulumHumansIntestinal AbsorptionLipid MetabolismTriglyceridesConceptsLipid absorptionSecretion of chylomicronsEpidemic of obesityDietary lipid absorptionDietary fat absorptionIntestinal lipid absorptionFatty acid transportersFatty acid uptakeDiscovery of familiesLiver fatty acidEndoplasmic reticulumAcid transportersClinical importanceFat absorptionPhysiological functionsIntracellular packagingComplex lipid synthesisLipid synthesisChylomicronsAcid uptakePhysiological regulationRecent advancesAcyltransferasesGolgiObesity
2006
The Identification of a Novel Endoplasmic Reticulum to Golgi SNARE Complex Used by the Prechylomicron Transport Vesicle*
Siddiqi SA, Siddiqi S, Mahan J, Peggs K, Gorelick FS, Mansbach CM. The Identification of a Novel Endoplasmic Reticulum to Golgi SNARE Complex Used by the Prechylomicron Transport Vesicle*. Journal Of Biological Chemistry 2006, 281: 20974-20982. PMID: 16735505, PMCID: PMC2833420, DOI: 10.1074/jbc.m601401200.Peer-Reviewed Original ResearchVesicle-associated membrane protein 7 is expressed in intestinal ER
Siddiqi SA, Mahan J, Siddiqi S, Gorelick FS, Mansbach CM. Vesicle-associated membrane protein 7 is expressed in intestinal ER. Journal Of Cell Science 2006, 119: 943-950. PMID: 16495485, PMCID: PMC2828367, DOI: 10.1242/jcs.02803.Peer-Reviewed Original Research