Binyam Mogessie, PhD
Assistant Professor of Molecular, Cellular, and Developmental Biology and of Obstetrics, Gynecology, and Reproductive SciencesCards
Appointments
Contact Info
Yale University
Department of Molecular, Cellular and Developmental Biology, 266 Whitney Avenue
New Haven, CT 06511
United States
About
Titles
Assistant Professor of Molecular, Cellular, and Developmental Biology and of Obstetrics, Gynecology, and Reproductive Sciences
Biography
Binyam Mogessie is faculty in the Department of Molecular, Cellular and Developmental Biology and Department of Obstetrics, Gynecology, and Reproductive Sciences at Yale University.
Binyam was born and raised in Ethiopia and moved to Germany where he studied biochemistry and cell biology at Jacobs University Bremen. He then moved to the UK for his PhD first at the Marie Curie Research Institute in Surrey and later at the Centre for Mechanochemical Cell Biology in Warwick, where he investigated the molecular mechanisms that organize the microtubule cytoskeleton during skeletal muscle differentiation and cell division. After receiving his PhD in cell biology from the University of London, he joined the MRC-LMB in Cambridge (and later at the Max Planck Institute in Göttingen, Germany), where he discovered a function of the actin cytoskeleton in accurate chromosome segregation during female . In 2019, Binyam established his independent research laboratory as a Wellcome Trust and Royal Society Sir Henry Dale fellow and HFSP Young Investigator at the University of Bristol. He joined the Yale MCDB faculty in July 2022 where his lab continues mechanistic cell biology studies of female meiosis and reproductive longevity.
Appointments
Molecular, Cellular, and Developmental Biology
Assistant ProfessorPrimaryObstetrics, Gynecology & Reproductive Sciences
Assistant ProfessorSecondary
Other Departments & Organizations
- Biochemistry, Quantitative Biology, Biophysics and Structural Biology (BQBS)
- Genomics, Genetics, and Epigenetics
- Molecular Cell Biology, Genetics and Development
- Molecular, Cellular, and Developmental Biology
- Obstetrics, Gynecology & Reproductive Sciences
- Plant Molecular Biology
- Yale Cancer Center
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
- Yale Stem Cell Center
Education & Training
- Postdoctoral Fellow
- Max Planck Institute for Biophysical Chemistry (2017)
- Postdoctoral Fellow
- MRC Laboratory of Molecular Biology (2015)
- PhD
- University of London, Institute of Cancer Research, Cell Biology (2011)
- BSc
- Jacobs University Bremen, Biochemistry and Cell Biology (2007)
Research
Overview
Medical Subject Headings (MeSH)
- View Lab Website
Mogessie Lab
Research at a Glance
Publications Timeline
Publications
2023
Actin limits egg aneuploidies associated with female reproductive aging.
Dunkley S, Mogessie B. Actin limits egg aneuploidies associated with female reproductive aging. Sci Adv 2023, 9: eadc9161. PMID: 36662854, DOI: 10.1126/sciadv.adc9161.Peer-Reviewed Original Research
2022
Cytoskeletal form and function in mammalian oocytes and zygotes.
Dunkley S, Scheffler K, Mogessie B. Cytoskeletal form and function in mammalian oocytes and zygotes. Curr Opin Cell Biol 2022, 75: 102073. PMID: 35364486, DOI: 10.1016/j.ceb.2022.02.007.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsThe prophase oocyte nucleus is a homeostatic G-actin buffer.
Scheffler K, Giannini F, Lemonnier T, Mogessie B. The prophase oocyte nucleus is a homeostatic G-actin buffer. J Cell Sci 2022, 135 PMID: 35112707, DOI: 10.1242/jcs.259807.Peer-Reviewed Original Research
2021
Seeing is believing: Representation as a powerful tool in the fight against racism in science.
Mogessie B. Seeing is believing: Representation as a powerful tool in the fight against racism in science. Cell Stem Cell 2021, 28: 793-795. PMID: 33961761, DOI: 10.1016/j.stem.2021.04.017.Peer-Reviewed Original ResearchTwo mechanisms drive pronuclear migration in mouse zygotes.
Scheffler K, Uraji J, Jentoft I, Cavazza T, Mönnich E, Mogessie B, Schuh M. Two mechanisms drive pronuclear migration in mouse zygotes. Nature Communications 2021, 12: 841. PMID: 33547291, PMCID: PMC7864974, DOI: 10.1038/s41467-021-21020-x.Peer-Reviewed Original Research
2020
Advances and surprises in a decade of oocyte meiosis research.
Mogessie B. Advances and surprises in a decade of oocyte meiosis research. Essays In Biochemistry 2020, 64: 263-275. PMID: 32538429, DOI: 10.1042/EBC20190068.Peer-Reviewed Original ResearchVisualization and Functional Analysis of Spindle Actin and Chromosome Segregation in Mammalian Oocytes.
Mogessie B. Visualization and Functional Analysis of Spindle Actin and Chromosome Segregation in Mammalian Oocytes. Methods In Molecular Biology (Clifton, N.J.) 2020, 2101: 267-295. PMID: 31879910, DOI: 10.1007/978-1-0716-0219-5_17.Peer-Reviewed Original Research
2019
Conducting Chromatin Motion: Actin Dynamizes Contents of the Oocyte Nucleus.
Mogessie B. Conducting Chromatin Motion: Actin Dynamizes Contents of the Oocyte Nucleus. Developmental Cell 2019, 51: 133-134. PMID: 31639365, DOI: 10.1016/j.devcel.2019.09.020.Peer-Reviewed Original ResearchMeeting report - Cell dynamics: organelle-cytoskeleton interface.
Mogessie B, Zenner H, Renkawitz J. Meeting report - Cell dynamics: organelle-cytoskeleton interface. Journal Of Cell Science 2019, 132 PMID: 31416851, DOI: 10.1242/jcs.236679.Peer-Reviewed Original Research
2018
Assembly and Positioning of the Oocyte Meiotic Spindle.
Mogessie B, Scheffler K, Schuh M. Assembly and Positioning of the Oocyte Meiotic Spindle. Annual Review Of Cell And Developmental Biology 2018, 34: 381-403. PMID: 30028643, DOI: 10.1146/annurev-cellbio-100616-060553.Peer-Reviewed Original Research
Academic Achievements and Community Involvement
activity Associate Editor
Journal ServiceeLifeReviewing EditorDetails11/01/2020 - Presentactivity Associate Editor
Journal ServiceMolecular Human ReproductionAssociate EditorDetails08/01/2019 - Presentactivity Council Member
Professional OrganizationsAmerican Society for Cell BiologyDetails2025 - Presenthonor Pew Scholar
National AwardThe Pew Charitable TrustsDetails09/01/2024honor Vallee Scholar
International AwardThe Vallee FoundationDetails09/01/2024
Links & Media
Media
- Super-resolution microscopy image showing stable actin filaments (Green) in the nucleus of a mouse oocyte closely interacting with chromatin (Magenta).
Related Links
Get In Touch
Contacts
Yale University
Department of Molecular, Cellular and Developmental Biology, 266 Whitney Avenue
New Haven, CT 06511
United States