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Measuring Synaptic Density in Parkinson's Disease with SV2A PET Imaging

Synaptic changes play a critical role in the pathogenesis and progression of PD. This study investigates the changes in synaptic density in individuals with PD by using positron emission tomography (PET) imaging with 11C-UCB-J, a recently developed PET radiotracer that binds to the synaptic vesicle glycoprotein, 2A.