Le Zhang, PhD
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About
Titles
Assistant Professor of Neurology and of Neuroscience
Biography
Le Zhang is an Assistant Professor of Neurology and of Neuroscience at Yale University School of Medicine. Dr. Zhang’s research focuses on the immune responses of the central nervous system in neurodegenerative diseases, including Parkinson’s disease, Alzheimer’s disease, HIV-associated neurocognitive disorder, and Multiple sclerosis, using cutting-edge single cell technologies.
Dr. Zhang obtained her B.S. in Biological Science from Peking University in 2004 and her Ph.D. in Molecular Biology and Biochemistry from the University of Hong Kong in 2010, where she studied epigenetic regulation in aging and senescence with Dr. Zhongjun Zhou. Dr. Zhang continued her training in epigenetics as a postdoctoral fellow in the laboratory of Dr. Zhaolan Zhou at the University of Pennsylvania School of Medicine in the field of neuroscience and as a research fellow with Dr. Jordan Kreidberg at Harvard Medical School in the area of development. After a short journey at Pfizer in the R&D of neuroscience, Dr. Zhang joined Yale School of Medicine as Associate Research Scientist, leading single cell research in neurological disorders, and started her current position as Assistant Professor in the Department of Neurology in 2020.
Appointments
Neurology
Assistant ProfessorPrimaryNeuroscience
Assistant ProfessorSecondary
Other Departments & Organizations
- Center for Brain & Mind Health
- Green College Affiliates
- Hafler Lab
- Interdepartmental Neuroscience Program
- Le Zhang Lab
- Neural Disorders
- Neurology
- Neuroscience
- Neuroscience Track
- Program for Neuroinflammation
- WHRY Pilot Project Program Investigators
- Women's Health Research at Yale
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
Education & Training
- Research Fellow
- Harvard Medical School (2016)
- Postdoctoral Fellow
- University of Pennsylvania School of Medicine (2011)
- PhD
- The University of Hong Kong (2010)
- BS
- Peking University (2004)
Research
Publications
scNAT: a deep learning method for integrating paired single-cell RNA and T cell receptor sequencing profiles
Zhu B, Wang Y, Ku L, van Dijk D, Zhang L, Hafler D, Zhao H. scNAT: a deep learning method for integrating paired single-cell RNA and T cell receptor sequencing profiles. Genome Biology 2023, 24: 292. PMID: 38111007, PMCID: PMC10726524, DOI: 10.1186/s13059-023-03129-y.Peer-Reviewed Original ResearchSingle-cell analysis reveals inflammatory interactions driving macular degeneration
Kuchroo M, DiStasio M, Song E, Calapkulu E, Zhang L, Ige M, Sheth A, Majdoubi A, Menon M, Tong A, Godavarthi A, Xing Y, Gigante S, Steach H, Huang J, Huguet G, Narain J, You K, Mourgkos G, Dhodapkar R, Hirn M, Rieck B, Wolf G, Krishnaswamy S, Hafler B. Single-cell analysis reveals inflammatory interactions driving macular degeneration. Nature Communications 2023, 14: 2589. PMID: 37147305, PMCID: PMC10162998, DOI: 10.1038/s41467-023-37025-7.Peer-Reviewed Original ResearchConceptsAge-related macular degenerationMacular degenerationNeurodegenerative diseasesNeurodegenerative conditionsLate-stage age-related macular degenerationPossible new therapeutic targetsPostmortem human retinaProgressive multiple sclerosisNew therapeutic targetsEarly phaseSingle-nucleus RNA sequencingInflammatory interactionsMultiple sclerosisInterleukin-1βDisease progressionControl retinasTherapeutic approachesGlial populationsGlial stateTherapeutic targetDisease pathogenesisRetinal diseasesAlzheimer's diseaseDiseaseHuman retina
Academic Achievements and Community Involvement
Links & Media
News
- July 23, 2024
Advancements in Women’s Health Research
- May 24, 2022
Le Zhang, PhD Wins Avenir Award for Research on Substance Use Disorders and HIV/AIDS
- April 11, 2022
The Brain and the Heart: Understanding How to Prevent and Treat Alzheimer’s Disease
- March 16, 2022
Revealing Communications Between Brain and Body