2001
Computed Tomography of the Head before Lumbar Puncture in Adults with Suspected Meningitis
Hasbun R, Abrahams J, Jekel J, Quagliarello V. Computed Tomography of the Head before Lumbar Puncture in Adults with Suspected Meningitis. New England Journal Of Medicine 2001, 345: 1727-1733. PMID: 11742046, DOI: 10.1056/nejmoa010399.Peer-Reviewed Original ResearchConceptsLumbar punctureAbnormal findingsNeurologic abnormalitiesCentral nervous system diseaseAbnormal visual fieldsHealth Stroke ScaleMild mass effectHistory of seizuresUnderwent lumbar punctureNervous system diseasesResults of CTMass effectNegative predictive valueBase lineStroke ScaleClinical characteristicsClinical featuresFacial palsyArm driftCT scanSystem diseasesComputed tomographyPatientsMeningitisPredictive value
1991
Ultrastructural localization of albumin transport across the cerebral microvasculature during experimental meningitis in the rat.
Quagliarello V, Ma A, Stukenbrok H, Palade G. Ultrastructural localization of albumin transport across the cerebral microvasculature during experimental meningitis in the rat. Journal Of Experimental Medicine 1991, 174: 657-672. PMID: 1875166, PMCID: PMC2118932, DOI: 10.1084/jem.174.3.657.Peer-Reviewed Original ResearchConceptsBlood-brain barrierBBB injuryExperimental meningitisCerebral microvasculatureOpen intercellular junctionsSpecific therapeutic interventionsBacterial meningitisBrain barrierIntracisternal inoculationMeningitisBrain cortexInjury mechanismMicrovascular segmentsTherapeutic interventionsIntercellular junctionsInducible increaseAu-BSAInjuryAbluminal sidePrecise mechanismSimilar uptakeAlbumin transportColloidal carbonTracer perfusionVenular leaksRecombinant human interleukin-1 induces meningitis and blood-brain barrier injury in the rat. Characterization and comparison with tumor necrosis factor.
Quagliarello V, Wispelwey B, Long W, Scheld W. Recombinant human interleukin-1 induces meningitis and blood-brain barrier injury in the rat. Characterization and comparison with tumor necrosis factor. Journal Of Clinical Investigation 1991, 87: 1360-1366. PMID: 2010549, PMCID: PMC295174, DOI: 10.1172/jci115140.Peer-Reviewed Original ResearchConceptsBlood-brain barrier injuryRIL-1 betaBBB injuryCerebrospinal fluidBarrier injuryBBB permeabilityInterleukin-1Central nervous system infectionInduction of meningitisNervous system infectionRecombinant human interleukin-1Tumor necrosis factorExperimental rat modelRIL-1 alphaHuman interleukin-1Systemic neutropeniaHost mediatorsCSF inflammationSystem infectionIgG monoclonal antibodiesNeutrophil emigrationRTNF alphaNecrosis factorRat modelIL-1
1986
Review: Recent Advances in the Pathogenesis and Pathophysiology of Bacterial Meningitis
Quagliarello V, Scheld W. Review: Recent Advances in the Pathogenesis and Pathophysiology of Bacterial Meningitis. The American Journal Of The Medical Sciences 1986, 292: 306-309. PMID: 3535498, DOI: 10.1097/00000441-198611000-00010.Peer-Reviewed Original ResearchConceptsBacterial meningitisHost defenseBactericidal antibiotic therapyInterstitial brain edemaIrreversible neuronal injuryBlood-brain barrier penetrationImpaired host defenseExperimental animal modelsVirulence factorsBrain barrier penetrationSurface virulence factorsBacterial virulence factorsMeningitis developmentPathophysiologic sequelaeMeningeal pathogensNeuronal injuryAntibiotic therapyBrain edemaWorldwide morbidityPathogenetic sequencePathogenetic stepsAnimal modelsMucosal colonizationMeningitisMorbidityMorphologic alterations of the blood-brain barrier with experimental meningitis in the rat. Temporal sequence and role of encapsulation.
Quagliarello V, Long W, Scheld W. Morphologic alterations of the blood-brain barrier with experimental meningitis in the rat. Temporal sequence and role of encapsulation. Journal Of Clinical Investigation 1986, 77: 1084-1095. PMID: 3514671, PMCID: PMC424442, DOI: 10.1172/jci112407.Peer-Reviewed Original ResearchConceptsBlood-brain barrierH. influenzae type b.Cerebral capillary endotheliumBBB permeabilityInfection durationMorphologic alterationsCapillary endotheliumEffective blood-brain barrierInduction of meningitisLonger infection durationUnencapsulated mutant strainCerebrospinal fluid bacterial concentrationsType B.Significant increaseIntercellular tight junctionsBBB injuryMeningitis inductionMeningeal pathogensExperimental meningitisHost clearanceCSF clearanceMeningitisMorphologic changesMorphologic explanationProgressive increase