2024
Feasibility of In-Hospital Administration of a Tool to Predict Persistent Post-ICU Functional Impairment Among Older ICU Survivors A Pilot Study
Stevenson J, Murphy T, Tessier-Sherman B, Pisani M, Gill T, Ferrante L. Feasibility of In-Hospital Administration of a Tool to Predict Persistent Post-ICU Functional Impairment Among Older ICU Survivors A Pilot Study. CHEST Critical Care 2024, 2: 100093. DOI: 10.1016/j.chstcc.2024.100093.Peer-Reviewed Original ResearchRisk prediction toolsICU survivorsIn-hospital administrationOlder adultsFunctional impairmentPilot studyIn-hospital mobilityOlder ICU survivorsDevelopment of risk prediction modelsHospital-related factorsIn-hospital factorsPresence of deliriumRisk prediction modelModel discriminationPersistent functional impairmentStatistical significanceHospital settingStudy designFeasibility thresholdDaily activitiesIncreased riskInternational Consensus ConferenceConsensus conferenceSurvivorsCritical illness“Faith and a sunny day”: Association of patient frailty with strain experienced by informal caregivers of older adults with non-muscle-invasive bladder cancer
Garg T, Maheshwari C, Frank K, Johns A, Rabinowitz K, Danella J, Becker H, Kirchner H, Nielsen M, Cohen H, Murphy T, McMullen C. “Faith and a sunny day”: Association of patient frailty with strain experienced by informal caregivers of older adults with non-muscle-invasive bladder cancer. Journal Of Geriatric Oncology 2024, 15: 102060. PMID: 39244892, DOI: 10.1016/j.jgo.2024.102060.Peer-Reviewed Original ResearchCaregiver Strain IndexDeficit accumulation indexInformal caregiversOlder adultsCaregiver strainInformal caregivers of older adultsCaregivers of older adultsAging-related conditionsCoping strategiesQualitative thematic content analysisDyads of older adultsCross-sectional survey studyConditions of older adultsInformal caregiver strainMultivariable negative binomial regressionThematic content analysisMeasures of frailtyCross-sectional studyNegative binomial regressionNon-muscle-invasive bladder cancerPre-frailSocial supportCaregiversSelf-report measuresGeriatric assessmentIn-Hospital Delirium and Disability and Cognitive Impairment After COVID-19 Hospitalization
Kaushik R, McAvay G, Murphy T, Acampora D, Araujo K, Charpentier P, Chattopadhyay S, Geda M, Gill T, Kaminski T, Lee S, Li J, Cohen A, Hajduk A, Ferrante L. In-Hospital Delirium and Disability and Cognitive Impairment After COVID-19 Hospitalization. JAMA Network Open 2024, 7: e2419640. PMID: 38954414, PMCID: PMC11220565, DOI: 10.1001/jamanetworkopen.2024.19640.Peer-Reviewed Original ResearchConceptsIn-hospital deliriumChart-Based Delirium Identification InstrumentOlder adultsFunctional disabilityCOVID-19 hospitalizationCognitive impairmentCohort studyAssociated with increased functional disabilityHospitalized older adultsIncreased functional disabilityAssociation of deliriumPostdischarge follow-upRisk of deliriumTertiary care systemFollow-upPresence of cognitive impairmentProspective cohort studyLogistic regression modelsOlder survivorsCare systemIncreasing cognitive impairmentMain OutcomesCOVID-19Hospital dischargePrimary outcomeStiffening of the human proximal pulmonary artery with increasing age
Manning E, Mishall P, Ramachandra A, Hassab A, Lamy J, Peters D, Murphy T, Heerdt P, Singh I, Downie S, Choudhary G, Tellides G, Humphrey J. Stiffening of the human proximal pulmonary artery with increasing age. Physiological Reports 2024, 12: e16090. PMID: 38884325, PMCID: PMC11181131, DOI: 10.14814/phy2.16090.Peer-Reviewed Original ResearchConceptsProximal pulmonary arteriesPulmonary arteryAge-related stiffeningRight ventricular ejection fractionVentricular ejection fractionMean wall thicknessEjection fractionNo significant differenceSystemic circulationLuminal caliberDiffusing capacityArterial stiffeningIncreasing ageSignificant differenceDistensionArteryWall thicknessAdverse effectsWall strainVessel diameterCyclic biaxial strainOrgan donorsAgeMicrostructural remodelingSocial Determinants of Health and Delivery of Rehabilitation to Older Adults During ICU Hospitalization
Jain S, Murphy T, Falvey J, Leo-Summers L, O’Leary J, Zang E, Gill T, Krumholz H, Ferrante L. Social Determinants of Health and Delivery of Rehabilitation to Older Adults During ICU Hospitalization. JAMA Network Open 2024, 7: e2410713. PMID: 38728030, PMCID: PMC11087837, DOI: 10.1001/jamanetworkopen.2024.10713.Peer-Reviewed Original ResearchConceptsSocial determinants of healthDeterminants of healthOccupational therapyPhysical therapyOlder adultsRural residentsIntensive care unit hospitalizationRehabilitation deliveryIntensive care unitSocial determinantsSocioeconomic disadvantageNational Health and Aging Trends StudyDelivery of physical therapyIllness hospitalizationFactors associated with lower oddsDelivery of rehabilitationIn-hospital rehabilitationMitigate functional declineMedicaid eligibilityBurden of disabilityHigh school educationDual MedicareTrends StudyMedicare claimsLength of stay
2023
Acute hospital use in older adults following the 2015 Dutch reform of long-term care: an interrupted time series analysis
Wammes J, Bakx P, Wouterse B, Buurman B, Murphy T, Vroomen J. Acute hospital use in older adults following the 2015 Dutch reform of long-term care: an interrupted time series analysis. The Lancet Healthy Longevity 2023, 4: e257-e264. PMID: 37269863, PMCID: PMC10316520, DOI: 10.1016/s2666-7568(23)00064-8.Peer-Reviewed Original ResearchConceptsIncident rate ratiosInterrupted time series analysisHospital dataOlder adultsAcute hospitalisationAcute hospital useAverage hospital lengthNational hospital dataMonthly rateLong-term careSupplementary Materials sectionAdvancing Translational SciencesHospital lengthHospital admissionAverage LOSLTC reformHospitalisationCurative careHospital useLongitudinal increaseRate ratioMedical specialistsNational InstituteAdultsLOSAssociation of Delirium With Functional and Cognitive Outcomes Among Older Survivors of a COVID-19 Hospitalization
Kaushik R, McAvay G, Murphy T, Cohen A, Hajduk A, Ferrante L. Association of Delirium With Functional and Cognitive Outcomes Among Older Survivors of a COVID-19 Hospitalization. 2023, a2754-a2754. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a2754.Peer-Reviewed Original ResearchSocial Vulnerability and Delivery of In-hospital Rehabilitation Services to Older Adults With Critical Illness
Jain S, Murphy T, O'Leary Jr J, Leo-Summers L, Zang E, Falvey J, Gill T, Krumholz H, Ferrante L. Social Vulnerability and Delivery of In-hospital Rehabilitation Services to Older Adults With Critical Illness. 2023, a2889-a2889. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a2889.Peer-Reviewed Original ResearchStatistical Methods for Quality and Productivity Improvement
Jiang W, Murphy T, Tsui K, Zhao Y. Statistical Methods for Quality and Productivity Improvement. Springer Handbooks 2023, 199-220. DOI: 10.1007/978-1-4471-7503-2_11.Peer-Reviewed Original ResearchStatistical process controlRobust designSPC methodsImportant statistical methodologiesObjective functionMultivariate quality characteristicsSquared error lossStatistical scienceProcess control methodsOptimization problemAutocorrelated dataStatistical methodologyStatistical methodsSPC theoryComplex systemsNoise ratio SNRPerformance measuresControl methodCharacteristic casesTolerance designProcess controlProcess varianceProcess responsesSingle quality characteristicMultiplicative combinationPerformance of a modified fracture risk assessment tool for fragility fracture prediction among older veterans living with HIV
Womack J, Murphy T, Leo-Summers L, Kidwai-Khan F, Skanderson M, Gill T, Gulanski B, Rodriguez-Barradas M, Tien P, Yin M, Hsieh E. Performance of a modified fracture risk assessment tool for fragility fracture prediction among older veterans living with HIV. AIDS 2023, 37: 1399-1407. PMID: 37070536, PMCID: PMC10329997, DOI: 10.1097/qad.0000000000003566.Peer-Reviewed Original ResearchConceptsFracture Risk Assessment ToolMajor osteoporotic fractureRisk assessment toolCohort studyHip fractureOsteoporotic fracturesVeterans Aging Cohort StudyAging Cohort StudyMultivariable logistic regressionType of fractureRace/ethnicityAssessment toolGlucocorticoid useHIV cohortFragility fracturesPrevious fractureRheumatoid arthritisSmoking statusFracture riskModest discriminationOlder veteransLogistic regressionOccurrence of fracturesHIVAlcohol useDistressing symptoms after major surgery among community‐living older persons
Gill T, Han L, Murphy T, Feder S, Gahbauer E, Leo‐Summers L, Becher R. Distressing symptoms after major surgery among community‐living older persons. Journal Of The American Geriatrics Society 2023, 71: 2430-2440. PMID: 37010784, PMCID: PMC10524276, DOI: 10.1111/jgs.18357.Peer-Reviewed Original ResearchConceptsCommunity-living older personsMajor surgeryDistressing symptomsArea Deprivation IndexOlder personsSocioeconomic disadvantageCommunity-living personsTiming of surgeryProspective longitudinal studyYears of ageQuality of lifeSymptom burdenNonelective surgeryPresurgery valuesElective surgeryMultivariable analysisFunctional outcomeNonelective proceduresChronic conditionsSurgerySymptomsProportional increaseMedicaid eligibilityDeprivation indexMonthsA multivariate joint model to adjust for random measurement error while handling skewness and correlation in dietary data in an epidemiologic study of mortality
Agogo G, Muchene L, Orindi B, Murphy T, Mwambi H, Allore H. A multivariate joint model to adjust for random measurement error while handling skewness and correlation in dietary data in an epidemiologic study of mortality. Annals Of Epidemiology 2023, 82: 8-15. PMID: 36972757, PMCID: PMC10239394, DOI: 10.1016/j.annepidem.2023.03.007.Peer-Reviewed Original ResearchConceptsCause mortalityDietary intakeNational Death Index mortality dataIntake levelsDietary fiber intakeNutrition Examination SurveyUS National HealthHazard ratioMultivariate joint modelExamination SurveyPerson intakeNational HealthUnhealthy dietFiber intakeEpidemiologic studiesDietary dataRelative hazardGlobal deathsMortality dataIntakeMortalitySubstantial proportionDeathDietary fiberLongitudinal measuresAssessing the contributions of modifiable risk factors to serious falls and fragility fractures among older persons living with HIV
Womack J, Murphy T, Leo‐Summers L, Bates J, Jarad S, Gill T, Hsieh E, Rodriguez‐Barradas M, Tien P, Yin M, Brandt C, Justice A. Assessing the contributions of modifiable risk factors to serious falls and fragility fractures among older persons living with HIV. Journal Of The American Geriatrics Society 2023, 71: 1891-1901. PMID: 36912153, PMCID: PMC10258163, DOI: 10.1111/jgs.18304.Peer-Reviewed Original ResearchConceptsModifiable risk factorsFragility fracturesRisk factorsAlcohol use disorderSerious fallsPhysiologic frailtyAntiretroviral therapyOlder PWHUse disordersVeterans Aging Cohort StudyMeasures of multimorbidityAging Cohort StudyBody mass indexMultivariable logistic modelAverage attributable fractionSuccessful prevention programsKey risk factorsOpioid prescriptionsCohort studyMass indexModifiable factorsSixth decadeAttributable fractionElevated riskICD9 codesAssociation of Sociodemographic Characteristics With 1-Year Hospital Readmission Among Adults Aged 18 to 55 Years With Acute Myocardial Infarction
Okafor C, Zhu C, Raparelli V, Murphy T, Arakaki A, D’Onofrio G, Tsang S, Smith M, Lichtman J, Spertus J, Pilote L, Dreyer R. Association of Sociodemographic Characteristics With 1-Year Hospital Readmission Among Adults Aged 18 to 55 Years With Acute Myocardial Infarction. JAMA Network Open 2023, 6: e2255843. PMID: 36787140, PMCID: PMC9929697, DOI: 10.1001/jamanetworkopen.2022.55843.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionYoung adultsHospital readmissionBlack raceMyocardial infarctionRacial differencesCardiac factorsSociodemographic characteristicsBlack individualsOdds of readmissionObservational cohort studyMedical record abstractionRisk of readmissionWhite individualsAdults Aged 18Year of dischargePostdischarge readmissionVIRGO StudyCause readmissionCohort studyPrimary outcomeRecord abstractionMulticenter studyAged 18Male ratio
2022
GERONTOLOGIC BIOSTATISTICS: MERGING WITH DATA SCIENCE AND TOWARD PERSONALIZED MEDICINE
Shardell M, Murphy T, Allore H. GERONTOLOGIC BIOSTATISTICS: MERGING WITH DATA SCIENCE AND TOWARD PERSONALIZED MEDICINE. Innovation In Aging 2022, 6: 177-177. PMCID: PMC9770254, DOI: 10.1093/geroni/igac059.708.Peer-Reviewed Original ResearchStudy of older personsEpidemiology of agingHealth-related interventionsAssessment of healthHeterogeneity of treatment effectsOlder personsOlder adultsIndividual sessionsTreatment effectsOlder patientsMultifactorial naturePublished studiesData scienceSessionsMultiple streams of dataStreams of dataMultimodal approachPersonalized medicineProgressive deteriorationIntegration of data scienceBehavioral phenotypesPatientsAgeInteractive visualizationPracticeYoung Women With Acute Myocardial Infarction: Risk Prediction Model for 1-Year Hospital Readmission
Dreyer R, Arakaki A, Raparelli V, Murphy T, Tsang S, D’Onofrio G, Wood M, Wright C, Pilote L. Young Women With Acute Myocardial Infarction: Risk Prediction Model for 1-Year Hospital Readmission. CJC Open 2022, 5: 335-344. PMID: 37377522, PMCID: PMC10290947, DOI: 10.1016/j.cjco.2022.12.004.Peer-Reviewed Original ResearchAcute myocardial infarctionRisk prediction modelHospital readmissionYoung womenMyocardial infarctionYoung AMI Patients (VIRGO) studyObstructive coronary artery diseaseRisk of readmissionCongestive heart failureProspective observational studyCoronary artery diseaseYoung female patientHospital readmission riskHospital complicationsHospital stayYounger patientsArtery diseaseClinical factorsHeart failureFemale patientsReadmission riskObservational studyModest discriminationHigh riskDepressive symptomsA risk model for decline in health status after acute myocardial infarction among older adults
Hajduk A, Dodson J, Murphy T, Chaudhry S. A risk model for decline in health status after acute myocardial infarction among older adults. Journal Of The American Geriatrics Society 2022, 71: 1228-1235. PMID: 36519774, PMCID: PMC10089939, DOI: 10.1111/jgs.18162.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionHealth status declineImportant patient-centered outcomesPatient-centered outcomesMyocardial infarctionStatus declineHealth statusOlder adultsShort Form-12 Physical Component ScorePhysical component scoreProspective cohort studyRisk prediction modelLogistic regression modelsOlder adult survivorsPredictive risk modelRisk modelCohort studyPatient ageValidation cohortC-statisticRisk factorsHigh riskLower riskAdult survivorsHospitalizationDistressing Symptoms Before and After Critical Illness Among Community-Living Older Adults
Jain S, Murphy T, Gahbauer E, Leo-Summers L, Ferrante L, Gill T. Distressing Symptoms Before and After Critical Illness Among Community-Living Older Adults. 2022, a2289-a2289. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a2289.Peer-Reviewed Original ResearchFactors Associated with Disability Over the 6 Months After a COVID Hospitalization Among Older Adults: The VALIANT (CO V ID-19 in Older A dults: A L ong i tudinal A ssessme nt ) Study
Ferrante L, Hajduk A, Cohen A, McAvay G, Geda M, Chattopadhyay S, Lee S, Acampora D, Gill T, Murphy T. Factors Associated with Disability Over the 6 Months After a COVID Hospitalization Among Older Adults: The VALIANT (CO V ID-19 in Older A dults: A L ong i tudinal A ssessme nt ) Study. 2022, a3696-a3696. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a3696.Peer-Reviewed Original Research
2021
The Impact of Social Isolation on Disability and Mortality Among Older Survivors of Critical Illness
Falvey J, Murphy T, Leo-Summers L, O'Leary J, Cohen A, Ferrante L. The Impact of Social Isolation on Disability and Mortality Among Older Survivors of Critical Illness. 2021, a1213-a1213. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a1213.Peer-Reviewed Original Research