2024
Adding Insult to Injury Sleep Deficiency in Hospitalized Patients
Mansour W, Knauert M. Adding Insult to Injury Sleep Deficiency in Hospitalized Patients. Sleep Medicine Clinics 2024, 19: 607-623. PMID: 39455181, DOI: 10.1016/j.jsmc.2024.07.008.Peer-Reviewed Original ResearchConceptsHospital settingSleep promotion protocolsSleep deficiencyHospitalized patientsNegative health effectsObjective sleep measuresSleep measurement techniquesHospital outcomesMedical conditionsEffects of sleep deficiencyStudy protocolIllness severitySleep promotionHospital environmentImpact multiple organ systemsMultiple organ systemsHospitalTreatment-related effectsSleep measuresContributing factorsPromotion protocolOrgan systemsOutcomesPatientsSleep
2023
0841 Feasibility of Actigraphy during a Daytime Bright Pilot Study in the Medical ICU
Lukas M, Doyle M, Intihar T, Wright K, Redeker N, Pisani M, Yaggi H, Knauert M. 0841 Feasibility of Actigraphy during a Daytime Bright Pilot Study in the Medical ICU. Sleep 2023, 46: a370-a371. DOI: 10.1093/sleep/zsad077.0841.Peer-Reviewed Original ResearchRest-activity patternsCircadian quotientMICU patientsPilot studyCosinor analysisStudy days 1Illness severity scoresCritical illnessMedical ICUMethods PatientsOngoing RCTsMean ageSeverity scorePatient outcomesActigraphy recordingsPatientsDay 1Patient careCircadian disruptionResults ThirteenActigraphyTotal recordingCircadian alignmentCircadian misalignmentMesor0842 Feasibility of daytime bright light exposure and urinary 6-sulfatoxymelatonin profiling in the medical ICU: A pilot study
Intihar T, Doyle M, Lukas M, Wright K, Redeker N, Pisani M, Yaggi H, Knauert M. 0842 Feasibility of daytime bright light exposure and urinary 6-sulfatoxymelatonin profiling in the medical ICU: A pilot study. Sleep 2023, 46: a371-a371. DOI: 10.1093/sleep/zsad077.0842.Peer-Reviewed Original ResearchMedical intensive care unitMICU patientsDaytime bright light exposureStudy days 1Intensive care unitIllness severity scoresBright light exposureWarrants further investigationCircadian outcomesMedical ICUCritical illnessIll patientsOngoing RCTsCare unitCircadian timingMean ageMelatonin useCircadian phaseSeverity scorePilot trialSufficient urinePatientsStudy daysBright lightDay 1
2022
Best Practice for Improving Sleep in the ICU. Part I: Non-pharmacologic
Korwin A, Knauert M. Best Practice for Improving Sleep in the ICU. Part I: Non-pharmacologic. 2022, 231-248. DOI: 10.1007/978-3-031-06447-0_14.ChaptersIntensive care unitICU patientsNormal sleepCritical care treatmentNon-pharmacologic therapiesNon-pharmacologic interventionsMost ICU patientsAbnormal circadian rhythmPoor quality sleepCircadian functionAcute illnessCritical illnessPatient characteristicsIll adultsCare unitChronotherapeutic interventionsCare treatmentSleep preferenceCurrent evidencePatient careCircadian disruptionSleepPatientsFuture interventionsPractice changeAdding Insult to Injury Sleep Deficiency in Hospitalized Patients
Mansour W, Knauert M. Adding Insult to Injury Sleep Deficiency in Hospitalized Patients. Clinics In Chest Medicine 2022, 43: 287-303. PMID: 35659026, PMCID: PMC9177053, DOI: 10.1016/j.ccm.2022.02.009.Peer-Reviewed Original ResearchConceptsSleep deficiencyHospital settingTreatment-related effectsMultiple organ systemsObjective sleep measurementsHospital outcomesHospitalized patientsIllness severityNegative health effectsSleep promotionStudy protocolPromotion protocolMedical conditionsSleep measurementsKey next stepOrgan systemsHealth effectsHospital environmentPatientsContributing factorDeficiencyOutcomesCommon problemInsultSetting0583 Tolerance and feasibility of daytime bright light in medical intensive care unit patients
Intihar T, Samojedny V, Korwin A, Knauert M. 0583 Tolerance and feasibility of daytime bright light in medical intensive care unit patients. Sleep 2022, 45: a256-a257. DOI: 10.1093/sleep/zsac079.580.Peer-Reviewed Original ResearchMICU patientsCritical illnessMedical ICUControl trialChronic Health Evaluation II scoreMedical intensive care unit patientsIntensive care unit patientsMean patient ageCare unit patientsSeverity of illnessBright light exposureRandomized control trialOngoing randomized control trialAcute PhysiologyII scoreUsual carePatient ageUnit patientsIll patientsBright-light interventionSixteen patientsPoor outcomeClinical investigationBright lightPatients
2021
Intermittent Feeding in Mechanically Ventilated Medical Intensive Care Unit Patients: Preliminary Outcomes
Korwin A, Honiden S, Intihar T, Wasden K, Powierza C, Knauert M. Intermittent Feeding in Mechanically Ventilated Medical Intensive Care Unit Patients: Preliminary Outcomes. 2021, a2889-a2889. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a2889.Peer-Reviewed Original ResearchA Pilot Protocol for Intermittent Feeding in Mechanically Ventilated Medical Intensive Care Unit Patients
Korwin A, Honiden S, Intihar T, Wasden K, Heard A, Powierza C, Knauert M. A Pilot Protocol for Intermittent Feeding in Mechanically Ventilated Medical Intensive Care Unit Patients. 2021, a2879-a2879. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a2879.Peer-Reviewed Original Research
2019
Circadian Biology and Its Importance to Intensive Care Unit Care and Outcomes
Gao C, Knauert M. Circadian Biology and Its Importance to Intensive Care Unit Care and Outcomes. Seminars In Respiratory And Critical Care Medicine 2019, 40: 629-637. PMID: 31826263, DOI: 10.1055/s-0039-1698394.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsIll patientsIntensive care unit careIntensive care unit practiceCircadian rhythmCurrent ICU practiceLow-risk interventionNumerous adverse outcomesUnit careCritical illnessImmune compromiseCardiovascular instabilityMetabolic derangementsAdverse outcomesICU practiceUnit practicesSleep disruptionCare improvementPatientsOutcomesSleepRhythmBright lightDaysCircadian biologyDeliriumPilot study: an intensive care unit sleep promotion protocol
Knauert MP, Pisani M, Redeker N, Murphy T, Araujo K, Jeon S, Yaggi H. Pilot study: an intensive care unit sleep promotion protocol. BMJ Open Respiratory Research 2019, 6: e000411. PMID: 31258916, PMCID: PMC6561389, DOI: 10.1136/bmjresp-2019-000411.Peer-Reviewed Original ResearchConceptsPromotion protocolProtocol armUsual careSleep protocolICU sleepProtocol patientsIll patientsPrimary outcomeSleep disruptionBedside careRoom entryPatientsRoom activitiesSleep opportunityCareLength of timeProtocol effectMean ARoom disturbancesGeneralised linear modelArmTime blocksEquivalent levelsRoom entranceActivityChapter 19 Sleep in Hospitalized Patients
Knauert M, Pisani M. Chapter 19 Sleep in Hospitalized Patients. 2019, 411-437. DOI: 10.1016/b978-0-12-813014-8.00019-6.ChaptersHospitalized patientsSleep disturbancesSleep disruptionSeverity of illnessLong-term health impactsPatient care activitiesMedical comorbiditiesCritical illnessPatient factorsCommon complaintSleep historyPatientsCare activitiesSleep deprivationIllnessLittle dataCircadian misalignmentHealth impactsAvailable literatureComorbiditiesHospitalSleepComplaintsTrialsSeverity
2017
Factors Influencing Patients' Sleep in the Intensive Care Unit: Perceptions of Patients and Clinical Staff.
Ding Q, Redeker NS, Pisani MA, Yaggi HK, Knauert MP. Factors Influencing Patients' Sleep in the Intensive Care Unit: Perceptions of Patients and Clinical Staff. American Journal Of Critical Care 2017, 26: 278-286. PMID: 28668912, PMCID: PMC5559223, DOI: 10.4037/ajcc2017333.Peer-Reviewed Original ResearchConceptsIntensive care unitMedical intensive care unitPatients' sleepCare unitSleep improvementIntensive care unit staffIntensive care unit environmentPerceptions of patientsAdequate sleep opportunityIll patientsBeliefs of staffClinical outcomesSleep qualityRestorative sleepUnit staffPatientsClinical staffPatient surrogatesSleepUnit environmentSleep opportunityOnly factorPatients' emotionsNonenvironmental factorsSemistructured interviews
2015
Sleep Loss and Circadian Rhythm Disruption in the Intensive Care Unit
Knauert MP, Haspel JA, Pisani MA. Sleep Loss and Circadian Rhythm Disruption in the Intensive Care Unit. Clinics In Chest Medicine 2015, 36: 419-429. PMID: 26304279, DOI: 10.1016/j.ccm.2015.05.008.BooksConceptsCritical illnessSleep disruptionAppropriate administrative supportIntensive care unit environmentIntensive care unitCircadian rhythm disruptionDelirium reductionIll patientsCare unitPharmacologic interventionsSleep disturbancesRhythm disruptionCare deliveryMultidisciplinary strategyUnit environmentSleep lossIllnessDisruptionPatientsEffective strategySleepEnvironmental factors
2014
Sleep and Sleep Disordered Breathing in Hospitalized Patients
Knauert MP, Malik V, Kamdar BB. Sleep and Sleep Disordered Breathing in Hospitalized Patients. Seminars In Respiratory And Critical Care Medicine 2014, 35: 582-592. PMID: 25353103, DOI: 10.1055/s-0034-1390080.BooksConceptsHospitalized patientsPoor sleep qualityPatient care activitiesInpatient deliriumAcute illnessPatients' sleepAdverse outcomesModifiable factorsPoor sleepBreathing increasesHospital settingSleep qualityPatientsMetabolic consequencesMultidisciplinary teamEarly identificationCare activitiesSleep deprivationSleepBreathingCurrent knowledgeFundamental physiological processesPhysiological processesDeliriumMedicationsFeasibility study of unattended polysomnography in medical intensive care unit patients
Knauert MP, Yaggi HK, Redeker NS, Murphy TE, Araujo KL, Pisani MA. Feasibility study of unattended polysomnography in medical intensive care unit patients. Heart & Lung 2014, 43: 445-452. PMID: 25023504, PMCID: PMC4150840, DOI: 10.1016/j.hrtlng.2014.06.049.Peer-Reviewed Original ResearchConceptsMedical intensive care unitPortable polysomnographySleep efficiencyMedical intensive care unit patientsIntensive care unit patientsSleep deprivationOvernight sleep durationCare unit patientsObservational pilot studyIntensive care unitIndicators of feasibilityUnattended polysomnographyUnit patientsIll patientsPatients' sleepCare unitArousal indexPSG studiesSleep durationPatientsInterpretable qualityPilot studyGold standardSleepSleep stages