Featured Publications
The DNA repair transcriptome in severe COPD
Sauler M, Lamontagne M, Finnemore E, Herazo-Maya JD, Tedrow J, Zhang X, Morneau JE, Sciurba F, Timens W, Paré PD, Lee PJ, Kaminski N, Bossé Y, Gomez JL. The DNA repair transcriptome in severe COPD. European Respiratory Journal 2018, 52: 1701994. PMID: 30190272, PMCID: PMC6422831, DOI: 10.1183/13993003.01994-2017.Peer-Reviewed Original ResearchConceptsDNA damage toleranceDNA repairInadequate DNA repairSevere chronic obstructive pulmonary diseaseChronic obstructive pulmonary diseaseRepair pathwaysGene correlation network analysisIntegrative genomics approachNucleotide excision repair pathwayDNA repair pathwaysGene Set Enrichment AnalysisExcision repair pathwayGlobal transcriptomic profilesDNA repair genesDNA repair responseCorrelation network analysisCOPD severityGenomic approachesLung tissue transcriptomeTranscriptomic differencesTranscriptomic changesTranscriptomic patternsRNA sequencingTissue transcriptomesTranscriptomic profiles
2022
Untargeted metabolomics analysis of esophageal squamous cell cancer progression
Yang T, Hui R, Nouws J, Sauler M, Zeng T, Wu Q. Untargeted metabolomics analysis of esophageal squamous cell cancer progression. Journal Of Translational Medicine 2022, 20: 127. PMID: 35287685, PMCID: PMC8919643, DOI: 10.1186/s12967-022-03311-z.Peer-Reviewed Original ResearchConceptsEsophageal squamous cell carcinomaPhosphatidylserine synthase 1Metabolic pathway genesGene Set Enrichment AnalysisESCC progressionMetabolic pathwaysGlycerophospholipid metabolismPathway genesTumor/node/metastasis stageStage IIMRNA expressionSquamous cell cancer progressionSquamous cell carcinomaKey metabolic pathwaysAdjacent cancerous tissuePotential therapeutic targetCharacteristic curve analysisGood diagnostic valueTandem mass spectrometry analysisCancer Genome AtlasKyoto EncyclopediaMass spectrometry analysisExpression heatmapsPathway databasesPoor prognosis