Featured Publications
Cumulative Anticholinergic Exposure Is Associated with Poor Memory and Executive Function in Older Men
Han L, Agostini JV, Allore HG. Cumulative Anticholinergic Exposure Is Associated with Poor Memory and Executive Function in Older Men. Journal Of The American Geriatrics Society 2008, 56: 2203-2210. PMID: 19093918, PMCID: PMC3952110, DOI: 10.1111/j.1532-5415.2008.02009.x.Peer-Reviewed Original ResearchConceptsTotal anticholinergic burdenCumulative anticholinergic exposureOlder menAnticholinergic medicationsAnticholinergic burdenAnticholinergic exposureCumulative exposureVeterans Affairs primary care clinicsExecutive functionAnticholinergic medication useDeleterious adverse effectsProspective cohort studySeverity of hypertensionCommunity-dwelling menPrimary care clinicsDaily Living ScalePotential risk factorsPrescription of drugsAnticholinergic scoreCohort studyMultiple medicationsAnticholinergic effectsMedication useCare clinicsPhysical function
2013
The impact of medication use on symptom burden in older patients with multiple medical morbidities
Han M, Tinetti M, Agostini J, Han L, Lee H, Walke L. The impact of medication use on symptom burden in older patients with multiple medical morbidities. Journal Of Clinical Gerontology And Geriatrics 2013, 4: 84-88. DOI: 10.1016/j.jcgg.2013.03.002.Peer-Reviewed Original ResearchSymptom burdenMedical morbidityMedication useVeterans Affairs primary care clinicsGreater medication useMultiple medical morbiditiesNumber of medicationsMedical record reviewPrimary care clinicsSurvey of patientsAdverse drug eventsCross-sectional studySeverity of symptomsAdditional medicationOlder patientsCare clinicsRecord reviewRoutine appointmentsDrug eventsChi-square analysisMorbiditySevere symptomsMedicationsLinear regression analysisSymptom categories
2007
Effects of Statin Use on Muscle Strength, Cognition, and Depressive Symptoms in Older Adults
Agostini JV, Tinetti ME, Han L, McAvay G, Foody JM, Concato J. Effects of Statin Use on Muscle Strength, Cognition, and Depressive Symptoms in Older Adults. Journal Of The American Geriatrics Society 2007, 55: 420-425. PMID: 17341246, DOI: 10.1111/j.1532-5415.2007.01071.x.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCognitionCohort StudiesComorbidityConnecticutDepressionDrug Therapy, CombinationDrug UtilizationFemaleGeriatric AssessmentHumansHydroxymethylglutaryl-CoA Reductase InhibitorsLongitudinal StudiesMaleMuscle StrengthNeuropsychological TestsPrimary Health CareProspective StudiesRisk AssessmentVeteransConceptsStatin usersMuscle strengthTest Part BStatin useDepression scoresEpidemiologic Studies Depression Scale scoreOutpatient primary care clinicsOlder adultsConcomitant medication useProximal muscle strengthObservational cohort studyPeripheral vascular diseasePrimary care clinicsDepression Scale scoresHigh-risk participantsHydroxymethyl glutaryl coenzymeCommunity-dwelling veteransCommunity-dwelling male participantsGreater comorbidityStatin therapyCohort studyMedian durationStatin prescriptionMedication useCare clinics