Featured Publications
Vaccination With Leptospira interrogans PF07598 Gene Family-Encoded Virulence Modifying Proteins Protects Mice From Severe Leptospirosis and Reduces Bacterial Load in the Liver and Kidney
Chaurasia R, Salovey A, Guo X, Desir G, Vinetz JM. Vaccination With Leptospira interrogans PF07598 Gene Family-Encoded Virulence Modifying Proteins Protects Mice From Severe Leptospirosis and Reduces Bacterial Load in the Liver and Kidney. Frontiers In Cellular And Infection Microbiology 2022, 12: 926994. PMID: 35837473, PMCID: PMC9274288, DOI: 10.3389/fcimb.2022.926994.Peer-Reviewed Original ResearchConceptsLethal challenge infectionChallenge infectionBacterial loadC3H/HeJ miceKey target organClinical pathogenesisSevere leptospirosisOrgan infectionProtein immunizationHeJ miceSerovar CanicolaTarget organsAnimal modelsLeptospirosis pathogenesisCellular pathogenesisMicePathogenesisInfectionLeptospira interrogansVirulence factorsModifying proteinsImmunizationKidneyLeptospirosisLiver
1995
Cellular mechanisms in the immune response to malaria in Plasmodium vinckei-infected mice
Perlmann H, Kumar S, Vinetz J, Kullberg M, Miller L, Perlmann P. Cellular mechanisms in the immune response to malaria in Plasmodium vinckei-infected mice. Infection And Immunity 1995, 63: 3987-3993. PMID: 7558309, PMCID: PMC173560, DOI: 10.1128/iai.63.10.3987-3993.1995.Peer-Reviewed Original ResearchConceptsImmune miceTh1 responseControl miceIL-4T cellsSpleen cellsIL-4-producing Th2 cellsBALB/c miceTumor necrosis factor alphaAbsence of elevationPlasmodium vinckei vinckeiImmunoglobulin E levelsInfection of miceGamma interferon productionNecrosis factor alphaChabaudi infectionAntigen exposureNonimmune miceImportant protective factorC miceSolid immunityTh2 cellsFactor alphaParasite antigensE levels
1990
Adoptive transfer of CD8+ T cells from immune animals does not transfer immunity to blood stage Plasmodium yoelii malaria.
Vinetz J, Kumar S, Good M, Fowlkes B, Berzofsky J, Miller L. Adoptive transfer of CD8+ T cells from immune animals does not transfer immunity to blood stage Plasmodium yoelii malaria. The Journal Of Immunology 1990, 144: 1069-74. PMID: 1967271, DOI: 10.4049/jimmunol.144.3.1069.Peer-Reviewed Original ResearchConceptsBlood-stage infectionT cellsSpleen cellsBALB/c miceBALB/c nu/nuMouse strainsClass I MHC AgMechanisms of CD8Vivo CD8 depletionAbsence of CD4Depletion of CD8P. yoelii infectionPopulation of CD4T-cell involvementAdoptive transfer experimentsPlasmodium yoelii 17XPlasmodium yoelii malariaUnfractionated spleen cellsBALB/cImmune CD4Immune CD8Vivo CD4CD8 depletionAdoptive transferImmune animals
1989
Interdependence of CD4+ T cells and malarial spleen in immunity to Plasmodium vinckei vinckei. Relevance to vaccine development.
Kumar S, Good M, Dontfraid F, Vinetz J, Miller L. Interdependence of CD4+ T cells and malarial spleen in immunity to Plasmodium vinckei vinckei. Relevance to vaccine development. The Journal Of Immunology 1989, 143: 2017-23. PMID: 2570802, DOI: 10.4049/jimmunol.143.6.2017.Peer-Reviewed Original ResearchConceptsBALB/c micePlasmodium vinckei vinckeiT cellsImmune miceC miceVivo depletionSpleen cellsNaive BALB/cAthymic nu/nu miceBALB/c nude miceC3H/HeN miceNu/nu miceImmune spleen cellsBALB/cLoss of immunityImmune CD4Malaria AgMalarial spleenVivo CD4Adoptive transferImmune spleenSplenectomized miceMalaria vaccineRodent malariaHeN mice