Featured Publications
Malaria Resilience in South America: Epidemiology, Vector Biology, and Immunology Insights from the Amazonian International Center of Excellence in Malaria Research Network in Peru and Brazil
Torres K, Ferreira MU, Castro MC, Escalante AA, Conn JE, Villasis E, da Silva Araujo M, Almeida G, Rodrigues PT, Corder RM, Fernandes ARJ, Calil PR, Ladeia WA, Garcia-Castillo SS, Gomez J, do Valle Antonelli LR, Gazzinelli RT, Golenbock DT, Llanos-Cuentas A, Gamboa D, Vinetz JM. Malaria Resilience in South America: Epidemiology, Vector Biology, and Immunology Insights from the Amazonian International Center of Excellence in Malaria Research Network in Peru and Brazil. American Journal Of Tropical Medicine And Hygiene 2022, 107: 168-181. PMID: 36228921, PMCID: PMC9662219, DOI: 10.4269/ajtmh.22-0127.Peer-Reviewed Original ResearchConceptsImmune responseMalaria epidemiologyMalaria controlImportant public health priorityHuman immune responsePublic health priorityWestern Brazilian Amazon regionHealth priorityHuman reservoirSociodemographic featuresMalaria researchEpidemiologyMultidisciplinary approachRapid reemergenceVector biologyElimination strategyResearch NetworkMalaria vectorsInternational CentreFurther researchBrazilian Amazon regionSouth AmericaMalariaImmunologyResponse
2024
Case Report: Plasmodium vivax Sporozoite Melanization in the Midgut and Salivary Gland of the Malaria Vector Anopheles darlingi
Dos Santos N, da Silva Bastos A, Araújo J, Pontual J, Medeiros J, Vinetz J, da Silva Araujo M. Case Report: Plasmodium vivax Sporozoite Melanization in the Midgut and Salivary Gland of the Malaria Vector Anopheles darlingi. American Journal Of Tropical Medicine And Hygiene 2024, 110: 444-447. PMID: 38350139, PMCID: PMC10919193, DOI: 10.4269/ajtmh.23-0349.Peer-Reviewed Original ResearchResponses to P. vivaxPlasmodium falciparum parasitesPrimary malaria vectorPlasmodium vivaxVector Anopheles darlingiFalciparum parasitesMalaria parasitesMalaria vector Anopheles darlingiPlasmodium parasitesSalivary glandsMalaria vectorsPlasmodiumAnopheline mosquitoesAnopheles darlingiMalariaDarlingiVivaxSalivaryGland
2023
Mutations Linked to Insecticide Resistance Not Detected in the Ace-1 or VGSC Genes in Nyssorhynchus darlingi from Multiple Localities in Amazonian Brazil and Peru
Bickersmith S, Jurczynski J, Sallum M, Chaves L, Bergo E, Rodriguez G, Morante C, Rios C, Saavedra M, Alava F, Gamboa D, Vinetz J, Conn J. Mutations Linked to Insecticide Resistance Not Detected in the Ace-1 or VGSC Genes in Nyssorhynchus darlingi from Multiple Localities in Amazonian Brazil and Peru. Genes 2023, 14: 1892. PMID: 37895241, PMCID: PMC10606710, DOI: 10.3390/genes14101892.Peer-Reviewed Original ResearchConceptsIndoor residual sprayMalaria endemic localitiesLow-intensity resistanceResistance mechanismsMalaria hotspotsCommon interventionInsecticidal netsMain resistance mechanismMalaria transmissionGenotypic detectionCodon 280Resistance mutationsEndemic localitiesPrimary malaria vectorVoltage-gated sodium channel geneResidual spraySodium channel geneChannel genesNon-synonymous mutationsACEPresent studyMalaria vectorsInterventionMutationsS6 segment
2022
Nyssorhynchus darlingi genome-wide studies related to microgeographic dispersion and blood-seeking behavior
Alvarez M, Alonso D, Kadri S, Rufalco-Moutinho P, Bernardes I, de Mello A, Souto A, Carrasco-Escobar G, Moreno M, Gamboa D, Vinetz J, Conn J, Ribolla P. Nyssorhynchus darlingi genome-wide studies related to microgeographic dispersion and blood-seeking behavior. Parasites & Vectors 2022, 15: 106. PMID: 35346342, PMCID: PMC8961893, DOI: 10.1186/s13071-022-05219-5.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesSingle nucleotide polymorphism (SNP) markersGenome-wide studiesLow-coverage whole-genome sequencingGenomic sequencing dataMajor malaria vectorCircadian rhythm genesFemale timingPopulation stratification analysisWhole-genome sequencingMicrogeographic scaleSNP markersPolymorphism markersPopulation structureSequencing dataAssociation studiesInsecticide resistanceDusk/dawnRhythm genesGenotype imputationGenesFemale mosquitoesMalaria vectorsBlood mealGenetic association