2023
Atrial fibrosis by cardiac MRI is a correlate for atrial stiffness in patients with atrial fibrillation
Lamy J, Taoutel R, Chamoun R, Akar J, Niederer S, Mojibian H, Huber S, Baldassarre L, Meadows J, Peters D. Atrial fibrosis by cardiac MRI is a correlate for atrial stiffness in patients with atrial fibrillation. The International Journal Of Cardiovascular Imaging 2023, 40: 107-117. PMID: 37857929, PMCID: PMC11378145, DOI: 10.1007/s10554-023-02968-x.Peer-Reviewed Original ResearchMeSH KeywordsAtrial FibrillationCatheter AblationContrast MediaFibrosisGadoliniumHeart AtriaHumansMagnetic Resonance ImagingPredictive Value of TestsConceptsLate gadolinium enhancementLA reservoir strainLeft atrial pressureLA volumeReservoir strainLA fibrosisLA strainStiffness indexLA late gadolinium enhancementAtrial stiffness indexMaximal LA volumeAtrial fibrillation cohortLA minimum volumeAtrial tissue fibrosisMaximum LA volumeCardiac MR examsAtrial stiffnessAtrial strainAF ablationAtrial pressureAF cohortAtrial fibrillationAtrial fibrosisPatient subgroupsLGE volume
2019
Recurrence quantification analysis of complex‐fractionated electrograms differentiates active and passive sites during atrial fibrillation
Baher A, Buck B, Fanarjian M, Mounsey J, Gehi A, Chung E, Akar FG, Webber CL, Akar JG, Hummel JP. Recurrence quantification analysis of complex‐fractionated electrograms differentiates active and passive sites during atrial fibrillation. Journal Of Cardiovascular Electrophysiology 2019, 30: 2229-2238. PMID: 31507008, DOI: 10.1111/jce.14161.Peer-Reviewed Original ResearchOutcomes and costs of remote patient monitoring among patients with implanted cardiac defibrillators: An economic model based on the PREDICT RM database
Hummel JP, Leipold RJ, Amorosi SL, Bao H, Deger KA, Jones PW, Kansal AR, Ott LS, Stern S, Stein K, Curtis JP, Akar JG. Outcomes and costs of remote patient monitoring among patients with implanted cardiac defibrillators: An economic model based on the PREDICT RM database. Journal Of Cardiovascular Electrophysiology 2019, 30: 1066-1077. PMID: 30938894, PMCID: PMC6850124, DOI: 10.1111/jce.13934.Peer-Reviewed Original ResearchAgedAged, 80 and overArrhythmias, CardiacCost-Benefit AnalysisDatabases, FactualDeath, Sudden, CardiacDefibrillators, ImplantableElectric CountershockFemaleHealth Care CostsHumansMaleMedicareModels, EconomicPatient ReadmissionPredictive Value of TestsQuality-Adjusted Life YearsRegistriesRemote Sensing TechnologyTelemetryTime FactorsTreatment OutcomeUnited States
2017
Application of Whole Exome Sequencing in the Clinical Diagnosis and Management of Inherited Cardiovascular Diseases in Adults
Seidelmann SB, Smith E, Subrahmanyan L, Dykas D, Abou Ziki MD, Azari B, Hannah-Shmouni F, Jiang Y, Akar JG, Marieb M, Jacoby D, Bale AE, Lifton RP, Mani A. Application of Whole Exome Sequencing in the Clinical Diagnosis and Management of Inherited Cardiovascular Diseases in Adults. Circulation Genomic And Precision Medicine 2017, 10: e001573. PMID: 28087566, PMCID: PMC5245580, DOI: 10.1161/circgenetics.116.001573.Peer-Reviewed Original ResearchConceptsWhole-exome sequencingSudden cardiac deathCardiovascular diseaseClinical diagnosisExome sequencingCardiac deathInherited cardiovascular diseaseCentre of careNovel candidate genesValuable screening toolAdult patientsRisk stratificationPrimary insultCardiac functionGenetic testingScreening toolDiagnosisCVD genesGenetic causeCardiovascular geneticsGenetic panelSuccess rateExome databasesPotential disease associationsPatients
2013
Plasma Profiles of Matrix Metalloproteinases and Tissue Inhibitors of the Metalloproteinases Predict Recurrence of Atrial Fibrillation Following Cardioversion
Mukherjee R, Akar JG, Wharton JM, Adams DK, McClure CD, Stroud RE, Rice AD, DeSantis SM, Spinale FG, Gold MR. Plasma Profiles of Matrix Metalloproteinases and Tissue Inhibitors of the Metalloproteinases Predict Recurrence of Atrial Fibrillation Following Cardioversion. Journal Of Cardiovascular Translational Research 2013, 6: 528-535. PMID: 23722357, DOI: 10.1007/s12265-013-9471-2.Peer-Reviewed Original ResearchMeSH KeywordsAgedAtrial FibrillationBiomarkersChi-Square DistributionC-Reactive ProteinElectric CountershockFibrosisHeart AtriaHumansLogistic ModelsMatrix MetalloproteinasesMiddle AgedMultivariate AnalysisNatriuretic Peptide, BrainPeptide FragmentsPredictive Value of TestsRecurrenceRisk FactorsTime FactorsTissue Inhibitor of MetalloproteinasesTreatment OutcomeConceptsAF recurrenceMatrix metalloproteinasesMMP-9TIMP-4MMP-3N-terminus pro B type natriuretic peptideHigh-sensitivity C-reactive protein levelsPro-B-type natriuretic peptideTissue inhibitorC-reactive protein levelsB-type natriuretic peptideLevels of MMPsAtrial fibrillation recurrenceNovel biomarker panelAtrial volumeNatriuretic peptideAtrial fibrosisSinus rhythmPredicts RecurrenceBiomarker panelRecurrenceMultivariate analysisPostcardioversionProtein levelsPlasma samples
2008
Endothelial dysfunction in heart failure identifies responders to cardiac resynchronization therapy
Akar JG, Al-Chekakie MO, Fugate T, Moran L, Froloshki B, Varma N, Santucci P, Wilber DJ, Matsumura ME. Endothelial dysfunction in heart failure identifies responders to cardiac resynchronization therapy. Heart Rhythm 2008, 5: 1229-1235. PMID: 18774094, DOI: 10.1016/j.hrthm.2008.05.027.Peer-Reviewed Original ResearchConceptsCardiac resynchronization therapyFlow-mediated dilationBaseline flow-mediated dilationBaseline endothelial dysfunctionAdditive prognostic valueEndothelial dysfunctionCRT respondersWalk distanceResynchronization therapyPrognostic valueBrachial artery flow-mediated dilationArtery flow-mediated dilationBaseline functional capacityEndothelial function assessmentHeart failure mortalityHeart failure outcomesLikelihood of responseLogistic regression analysisQuality of lifeCurrent selection criteriaEndothelial functionHeart failureQRS durationCurrent guidelinesFunction assessment
2006
Predicting elevated defibrillation energy requirements in heart failure with reasonable probability
Akar JG. Predicting elevated defibrillation energy requirements in heart failure with reasonable probability. Heart Rhythm 2006, 3: 1017-1018. PMID: 16945793, DOI: 10.1016/j.hrthm.2006.06.015.Peer-Reviewed Original ResearchDefibrillators, ImplantableElectrocardiographyHeart FailureHumansPredictive Value of TestsVentricular Fibrillation