2021
Clinical characteristics and outcomes for 7,995 patients with SARS-CoV-2 infection
McPadden J, Warner F, Young HP, Hurley NC, Pulk RA, Singh A, Durant TJS, Gong G, Desai N, Haimovich A, Taylor RA, Gunel M, Dela Cruz CS, Farhadian SF, Siner J, Villanueva M, Churchwell K, Hsiao A, Torre CJ, Velazquez EJ, Herbst RS, Iwasaki A, Ko AI, Mortazavi BJ, Krumholz HM, Schulz WL. Clinical characteristics and outcomes for 7,995 patients with SARS-CoV-2 infection. PLOS ONE 2021, 16: e0243291. PMID: 33788846, PMCID: PMC8011821, DOI: 10.1371/journal.pone.0243291.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionYale New Haven HealthSARS-CoV-2Hospital mortalityRisk of admissionMale sexRisk factorsSARS-CoV-2 testingInvasive mechanical ventilationSevere acute respiratory syndrome virusBurden of diseaseRT-PCR testingAcademic health systemDiverse patient populationsRespiratory syndrome virusEthnic groupsAdult patientsClinical characteristicsDischarge dispositionRespiratory supportPrimary outcomeTreatment guidelinesMechanical ventilationRetrospective studyPatient populationIntermediate‐dose anticoagulation, aspirin, and in‐hospital mortality in COVID‐19: A propensity score‐matched analysis
Meizlish ML, Goshua G, Liu Y, Fine R, Amin K, Chang E, DeFilippo N, Keating C, Liu Y, Mankbadi M, McManus D, Wang SY, Price C, Bona RD, Chaar C, Chun HJ, Pine AB, Rinder HM, Siner JM, Neuberg DS, Owusu KA, Lee AI. Intermediate‐dose anticoagulation, aspirin, and in‐hospital mortality in COVID‐19: A propensity score‐matched analysis. American Journal Of Hematology 2021, 96: 471-479. PMID: 33476420, PMCID: PMC8013588, DOI: 10.1002/ajh.26102.Peer-Reviewed Original ResearchConceptsProphylactic-dose anticoagulationAntiplatelet therapyHospital deathCumulative incidenceMultivariable regression modelsHospital mortalityHospitalized adult COVID-19 patientsAdult COVID-19 patientsPropensity score-matched patientsPropensity score-matched analysisCOVID-19Intensive antithrombotic therapyIntermediate-dose anticoagulationCohort of patientsCOVID-19 patientsPatient-specific covariatesAnticoagulation cohortAspirin cohortDose anticoagulationAntithrombotic therapyThrombotic complicationsHospitalized patientsPrimary outcomeIllness severityRegression models
2020
Abnormalities of Aspiration and Swallowing Function in Survivors of Acute Respiratory Failure
Langmore SE, Krisciunas GP, Warner H, White SD, Dvorkin D, Fink D, McNally E, Scheel R, Higgins C, Levitt JE, McKeehan J, Deane S, Siner JM, Vojnik R, Moss M. Abnormalities of Aspiration and Swallowing Function in Survivors of Acute Respiratory Failure. Dysphagia 2020, 36: 831-841. PMID: 33156398, DOI: 10.1007/s00455-020-10199-8.Peer-Reviewed Original ResearchConceptsAcute respiratory failureRespiratory failureARF survivorsMechanical ventilationMultivariable analysisUniversity-based tertiary medical centerPenetration-Aspiration Scale scoresUpper airway edemaProspective cohort studyTertiary medical centerLaryngeal structuresFlexible endoscopic evaluationAirway edemaARF patientsSecondary outcomesCohort studyFunction abnormalitiesPrimary outcomeEndoscopic evaluationPharyngeal weaknessSwallowing examinationSwallowing functionIntensive carePhysiologic abnormalitiesUnivariate analysis
2015
Protocols and Hospital Mortality in Critically Ill Patients
Sevransky JE, Checkley W, Herrera P, Pickering BW, Barr J, Brown SM, Chang SY, Chong D, Kaufman D, Fremont RD, Girard TD, Hoag J, Johnson SB, Kerlin MP, Liebler J, O’Brien J, O’Keefe T, Park PK, Pastores SM, Patil N, Pietropaoli AP, Putman M, Rice TW, Rotello L, Siner J, Sajid S, Murphy DJ, Martin GS. Protocols and Hospital Mortality in Critically Ill Patients. Critical Care Medicine 2015, 43: 2076-2084. PMID: 26110488, PMCID: PMC5673100, DOI: 10.1097/ccm.0000000000001157.Peer-Reviewed Original ResearchConceptsHospital mortalityIll patientsProtocol complianceClinical protocolsUnited States Critical IllnessAcute respiratory distress syndromeSpontaneous breathing trialLung-protective ventilationRespiratory distress syndromeLength of stayComplete outcome dataPatients 1 dayVentilator management protocolsSuperior patient outcomesLack of associationSingle variable analysisDesirable therapyBreathing trialProtective ventilationCritical illnessDistress syndromeICU protocolPrimary outcomeMechanical ventilationMultivariable analysis