2024
Bladder Symptoms Prvoked by Short, Rapid Acting Loop Diuretics: A Frequent But Often Overlooked Problem
Wilcox C, Pourafshar N, Han K, Shah S, Sussman R, Testani J, Packer M, Rossignol P, Zannad F, Pitt B, Shah S. Bladder Symptoms Prvoked by Short, Rapid Acting Loop Diuretics: A Frequent But Often Overlooked Problem. American Journal Of Hypertension 2024, hpae139. PMID: 39485998, DOI: 10.1093/ajh/hpae139.Peer-Reviewed Original ResearchCongestive heart failureChronic kidney diseaseBladder dysfunctionOveractive bladderLoop diureticsCardiovascular diseaseFormulations of loop diureticsSymptoms of overactive bladderSymptoms of urinary urgencyUrinary tract symptomsExtended-release formulationType 2 inhibitorsImpaired quality of lifeWorsening of symptomsPatients seeking careAdult US populationResistant hypertensionUrinary urgencyBladder symptomsReceptor antagonistBladder contractionsSodium-glucoseUrinary incontinenceHeart failureDiureticsSex differences in proteomics of cardiovascular disease: results from the Yale-CMD registry
Liu Y, Wang Z, Collins S, Testani J, Kleinstein S, Safdar B. Sex differences in proteomics of cardiovascular disease: results from the Yale-CMD registry. European Heart Journal 2024, 45: ehae666.3091. DOI: 10.1093/eurheartj/ehae666.3091.Peer-Reviewed Original ResearchCoronary microvascular dysfunctionCoronary artery diseaseUpregulation of lipidCardiovascular diseaseAcute heart failureCoronary artery disease cohortHistory of diabetesPathophysiology of CVDProximity extension assayBody mass indexSignificant sex differencesRegulation of blood flowSerum proteomic profilesSex differencesProteomic profilingAngiogenesis-related proteinsCardiac PET/CTHemodynamic instabilityIschemic symptomsMicrovascular dysfunctionFalse discovery rateHeart failureFebrile illnessFunctional pathway analysisMass index
2023
Cardiorenal interactions in heart failure: insights from recent therapeutic advances
Damman K, Testani J. Cardiorenal interactions in heart failure: insights from recent therapeutic advances. Cardiovascular Research 2023, 120: 1372-1384. PMID: 37364186, PMCID: PMC11472538, DOI: 10.1093/cvr/cvad096.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsHeart failureRisk patientsCardiovascular diseaseNew therapiesHigh cardiovascular risk patientsOutcomes of patientsCardiovascular risk patientsChronic kidney diseaseHigh-risk patientsRecent therapeutic advancesSpecific drug classesHigh mortality rateHealth care expendituresCardiorenal continuumCardiorenal interactionsMRA therapyRenal endpointsCardiovascular eventsCardiorenal diseaseKidney diseaseTherapeutic advancesDrug classesTherapeutic approachesMortality ratePatients
2017
Chapter 6 Animal Models for Cardiovascular Research
Shen Y, Chen L, Testani J, Regan C, Shannon R. Chapter 6 Animal Models for Cardiovascular Research. 2017, 147-174. DOI: 10.1016/b978-0-12-809468-6.00006-1.ChaptersAnimal modelsLarge animal modelSuitable large animal modelGood translational modelChapter 6 Animal ModelsSmall animal modelsTransgenic animal modelsExciting therapeutic interventionCardiovascular functionCardiovascular diseaseCardiovascular parametersClinical studiesClinical trailsRodent modelsTherapeutic interventionsTranslational modelLaboratory animalsCardiovascular researchNovel insightsRatsDiseaseMice
2015
The Impact of Donor and Recipient Renal Dysfunction on Cardiac Allograft Survival: Insights Into Reno-Cardiac Interactions
Laur O, Brisco MA, Kula AJ, Cheng SJ, Mangi AA, Bellumkonda L, Jacoby DL, Coca S, Tang WH, Parikh CR, Testani JM. The Impact of Donor and Recipient Renal Dysfunction on Cardiac Allograft Survival: Insights Into Reno-Cardiac Interactions. Journal Of Cardiac Failure 2015, 22: 368-375. PMID: 26616578, PMCID: PMC4904299, DOI: 10.1016/j.cardfail.2015.11.009.Peer-Reviewed Original ResearchConceptsRenal dysfunctionCardiac transplantationAdverse recipient outcomesCardiac allograft survivalOrgan Sharing registryGlomerular filtration ratePotent risk factorImpact of donorAllograft survivalCardiac allograftsRecipient deathRecipient outcomesUnited NetworkAdverse outcomesFiltration rateMyocardial necrosisRisk factorsCardiovascular diseaseHigh riskDonor characteristicsOlder ageRetransplantationDeathTransplantationDysfunction