Featured Publications
Prevalence of and risk factors for vertebral fracture and low bone mineral density among Peruvian women aging with HIV
Cabrera D, Cornejo M, Slotkin R, Pinedo Y, Yu W, Guan W, Garcia P, Hsieh E. Prevalence of and risk factors for vertebral fracture and low bone mineral density among Peruvian women aging with HIV. Archives Of Osteoporosis 2023, 18: 64. PMID: 37160770, PMCID: PMC10170032, DOI: 10.1007/s11657-023-01250-w.Peer-Reviewed Original ResearchConceptsBone mineral densityLow bone mineral densityThoracolumbar X-rayVertebral fracturesFemoral neckRisk factorsLumbar spineOsteoporosis treatmentTotal hipTreatment gapMineral densityTotal hip bone mineral densityPresence of VFsPeruvian womenTH bone mineral densityHip bone mineral densityFN bone mineral densityLower FN BMDSubset of patientsGenant semiquantitative methodLower femoral neckImportant treatment gapsKey risk factorsAntiretroviral therapyFRAX score
2023
Performance of a modified fracture risk assessment tool for fragility fracture prediction among older veterans living with HIV
Womack J, Murphy T, Leo-Summers L, Kidwai-Khan F, Skanderson M, Gill T, Gulanski B, Rodriguez-Barradas M, Tien P, Yin M, Hsieh E. Performance of a modified fracture risk assessment tool for fragility fracture prediction among older veterans living with HIV. AIDS 2023, 37: 1399-1407. PMID: 37070536, PMCID: PMC10329997, DOI: 10.1097/qad.0000000000003566.Peer-Reviewed Original ResearchMeSH KeywordsBone DensityCohort StudiesHip FracturesHIV InfectionsHumansOsteoporotic FracturesRisk AssessmentRisk FactorsVeteransConceptsFracture Risk Assessment ToolMajor osteoporotic fractureRisk assessment toolCohort studyHip fractureOsteoporotic fracturesVeterans Aging Cohort StudyAging Cohort StudyMultivariable logistic regressionType of fractureRace/ethnicityAssessment toolGlucocorticoid useHIV cohortFragility fracturesPrevious fractureRheumatoid arthritisSmoking statusFracture riskModest discriminationOlder veteransLogistic regressionOccurrence of fracturesHIVAlcohol useAssessing the contributions of modifiable risk factors to serious falls and fragility fractures among older persons living with HIV
Womack J, Murphy T, Leo‐Summers L, Bates J, Jarad S, Gill T, Hsieh E, Rodriguez‐Barradas M, Tien P, Yin M, Brandt C, Justice A. Assessing the contributions of modifiable risk factors to serious falls and fragility fractures among older persons living with HIV. Journal Of The American Geriatrics Society 2023, 71: 1891-1901. PMID: 36912153, PMCID: PMC10258163, DOI: 10.1111/jgs.18304.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAlcoholismCohort StudiesFractures, BoneFrailtyHIV InfectionsHumansRisk FactorsConceptsModifiable risk factorsFragility fracturesRisk factorsAlcohol use disorderSerious fallsPhysiologic frailtyAntiretroviral therapyOlder PWHUse disordersVeterans Aging Cohort StudyMeasures of multimorbidityAging Cohort StudyBody mass indexMultivariable logistic modelAverage attributable fractionSuccessful prevention programsKey risk factorsOpioid prescriptionsCohort studyMass indexModifiable factorsSixth decadeAttributable fractionElevated riskICD9 codes
2022
Predictive Risk Model for Serious Falls Among Older Persons Living With HIV
Womack JA, Murphy TE, Leo-Summers L, Bates J, Jarad S, Smith AC, Gill TM, Hsieh E, Rodriguez-Barradas MC, Tien PC, Yin MT, Brandt CA, Justice AC. Predictive Risk Model for Serious Falls Among Older Persons Living With HIV. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2022, 91: 168-174. PMID: 36094483, PMCID: PMC9470988, DOI: 10.1097/qai.0000000000003030.Peer-Reviewed Original ResearchMeSH KeywordsAccidental FallsAgedAged, 80 and overAgingCohort StudiesHIV InfectionsHumansMiddle AgedPolypharmacyConceptsMiddle-aged veteransOlder PWHAntiretroviral therapySerious fallsOlder personsVeterans Aging Cohort StudyMeasures of multimorbidityAging Cohort StudyBody mass indexMultivariable logistic regressionPredictive risk modelCohort studyMass indexInjury codesElevated riskGeneral populationSix monthsPWHLogistic regressionPotential predictorsSubstance useRadiology reportsHIVExternal causesVeteransHealth-related quality of life among women aging with and without HIV in Peru
Cabrera DM, Chen M, Cornejo MP, Pinedo Y, Garcia PJ, Hsieh E. Health-related quality of life among women aging with and without HIV in Peru. PLOS ONE 2022, 17: e0269000. PMID: 35679332, PMCID: PMC9182248, DOI: 10.1371/journal.pone.0269000.Peer-Reviewed Original ResearchConceptsHealth-related qualityMental componentPhysical activityCell countLower health-related qualityShort Form Health SurveyComponent scoresHRQoL of womenLarge HIV clinicMental component scorePhysical component scoreForm Health SurveyStatistical significanceSummary component scoresCross-sectional studyRegression analysisChronic comorbiditiesHIV clinicHIV severitySF-36Mean ageRole limitationsPhysical functioningClinical dataHealth SurveyIntersectionality of stigmas and health-related quality of life in people ageing with HIV in China, Europe, and Latin America
Hsieh E, Polo R, Qian HZ, Fuster-RuizdeApodaca MJ, Del Amo J. Intersectionality of stigmas and health-related quality of life in people ageing with HIV in China, Europe, and Latin America. The Lancet Healthy Longevity 2022, 3: e206-e215. PMID: 36098292, DOI: 10.1016/s2666-7568(22)00003-4.Peer-Reviewed Original Research
2021
HIV care using differentiated service delivery during the COVID‐19 pandemic: a nationwide cohort study in the US Department of Veterans Affairs
McGinnis KA, Skanderson M, Justice AC, Akgün KM, Tate JP, King JT, Rentsch CT, Marconi VC, Hsieh E, Ruser C, Kidwai‐Khan F, Yousefzadeh R, Erdos J, Park LS. HIV care using differentiated service delivery during the COVID‐19 pandemic: a nationwide cohort study in the US Department of Veterans Affairs. Journal Of The International AIDS Society 2021, 24: e25810. PMID: 34713585, PMCID: PMC8554215, DOI: 10.1002/jia2.25810.Peer-Reviewed Original ResearchMeSH KeywordsCohort StudiesCOVID-19FemaleHIV InfectionsHumansMalePandemicsSARS-CoV-2United StatesVeteransConceptsVeterans AffairsClinic visitsCohort studyVL testARV coverageCOVID-19 pandemicVeterans Aging Cohort StudyHIV healthcare deliveryNationwide cohort studyAging Cohort StudyViral load testsDifferentiated service deliveryHealthcare deliveryHIV careMost patientsPharmacy recordsVL testingCalendar periodHealthcare encountersOverall healthARVVirtual healthcareVirtual visitsVisitsService deliveryIncident Rheumatoid Arthritis in HIV Infection: Epidemiology and Treatment
Hanberg JS, Hsieh E, Akgün KM, Weinstein E, Fraenkel L, Justice AC, Team T. Incident Rheumatoid Arthritis in HIV Infection: Epidemiology and Treatment. Arthritis & Rheumatology 2021, 73: 2189-2199. PMID: 34042306, DOI: 10.1002/art.41802.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntirheumatic AgentsArthritis, RheumatoidComorbidityFemaleHIV InfectionsHumansIncidenceMaleMiddle AgedPrevalenceConceptsDisease-modifying antirheumatic drugsIncident rheumatoid arthritisDiagnosis of RARA patientsRheumatoid arthritisRheumatoid factorUninfected individualsRheumatology/European AllianceHigh titersVeterans Aging Cohort StudyRA-specific autoantibodiesRheumatology 2010 criteriaTenth Revision codesAging Cohort StudyIncidence rate ratiosHigh autoantibody titersICD-10 codesDMARD useUninfected veteransAntirheumatic drugsAutoantibody titersCohort studyImmunosuppressed populationHIV infectionMedical chartsBrief Report: Are Serious Falls Associated With Subsequent Fragility Fractures Among Veterans Living With HIV?
Womack JA, Murphy TE, Ramsey C, Bathulapalli H, Leo-Summers L, Smith AC, Bates J, Jarad S, Gill TM, Hsieh E, Rodriguez-Barradas MC, Tien PC, Yin MT, Brandt C, Justice AC. Brief Report: Are Serious Falls Associated With Subsequent Fragility Fractures Among Veterans Living With HIV? JAIDS Journal Of Acquired Immune Deficiency Syndromes 2021, 88: 192-196. PMID: 34506360, PMCID: PMC8513792, DOI: 10.1097/qai.0000000000002752.Peer-Reviewed Original ResearchConceptsSubsequent fragility fracturesFragility fracturesAntiretroviral therapySerious fallsRisk factorsVeterans Aging Cohort StudyAging Cohort StudyMultivariable logistic regressionUpper arm fracturesMiddle-aged populationYears of ageAlcohol use disorderCohort studyHip fractureVertebral fracturesArm fracturesInjury codesICD9 codesGeneral populationUse disordersLogistic regressionIntegrase inhibitorsOlder adultsRadiology reportsHIVValidation of a six-item dietary calcium screening tool among HIV patients in China
Tseng LY, Xie W, Pan W, Lyu H, Yu Z, Shi W, He Y, Chen W, Li T, Hsieh E. Validation of a six-item dietary calcium screening tool among HIV patients in China. Public Health Nutrition 2021, 24: 4786-4795. PMID: 33820577, PMCID: PMC8600937, DOI: 10.1017/s1368980021001427.Peer-Reviewed Original ResearchMeSH KeywordsAdultCalcium, DietaryChinaDiet RecordsDiet SurveysHIV InfectionsHumansMaleReproducibility of ResultsConceptsSix-item toolAdjacent quartilesClinical practiceScreening toolClinical risk factorsFollow-up screeningModerate relative validityTime-point studyHIV patientsAverage BMIBone healthMean ageOutpatient settingNutritional assessmentRisk factorsRoutine screeningDietary CaHealthy dietDisease preventionHIVFurther assessmentRelative validityAdequate CaChinese individualsTarget populationLong-term trabecular bone score and bone mineral density changes in Chinese antiretroviral-treated HIV-infected individuals
Guan W, Pan W, Yu W, Cao W, Lin Q, Zhang Z, Song X, Li Y, Tian J, Xu Y, Li T, Hsieh E. Long-term trabecular bone score and bone mineral density changes in Chinese antiretroviral-treated HIV-infected individuals. Archives Of Osteoporosis 2021, 16: 41. PMID: 33624129, PMCID: PMC9675940, DOI: 10.1007/s11657-021-00890-0.Peer-Reviewed Original ResearchMeSH KeywordsAbsorptiometry, PhotonAdultBone DensityCancellous BoneChinaHIV InfectionsHumansLumbar VertebraeRetrospective StudiesConceptsTrabecular bone scoreBone mineral densityTH bone mineral densityNormal bone mineral densityAntiretroviral therapyBone scoreART initiationFemoral neckMineral densityBone microarchitectureTotal hip (TH) BMDLumbar spine (LS) BMDBone mineral density changesFN bone mineral densityLarge tertiary care hospitalRetrospective chart reviewTertiary care hospitalMineral density changesMean percent decreaseResultsFour hundred fiftyPercent decreaseAdult PWHChart reviewCare hospitalBMD changesAging with HIV in Latin America and the Caribbean: a Systematic Review
Cabrera DM, Diaz MM, Grimshaw A, Salvatierra J, Garcia PJ, Hsieh E. Aging with HIV in Latin America and the Caribbean: a Systematic Review. Current HIV/AIDS Reports 2021, 18: 1-47. PMID: 33400168, PMCID: PMC8059362, DOI: 10.1007/s11904-020-00538-7.Peer-Reviewed Original ResearchConceptsNon-communicable diseasesSystematic reviewCommon non-communicable diseasesChronic non-communicable diseasesAntiretroviral treatment programLongitudinal studyPrevalence of illnessPurpose of ReviewWithAge-related findingsChronic comorbiditiesOlder PWHMiddle-income countriesHIVSummaryOur resultsScreening instrumentTreatment programPopulation 40Recent FindingsOfPWHAvailable evidencePeer-reviewed literatureSignificant predictorsComorbiditiesAgeBurdenKnowledge and Impact of COVID-19 on Middle-Aged and Older People Living with HIV in Lima, Peru
Diaz MM, Cabrera DM, Gil-Zacarias M, Ramirez V, Saavedra M, Cárcamo C, Hsieh E, Garcia PJ. Knowledge and Impact of COVID-19 on Middle-Aged and Older People Living with HIV in Lima, Peru. Journal Of The International Association Of Providers Of AIDS Care (JIAPAC) 2021, 20: 23259582211056760. PMID: 34870508, PMCID: PMC8655474, DOI: 10.1177/23259582211056760.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCOVID-19Cross-Sectional StudiesFemaleHIV InfectionsHumansMaleMiddle AgedPeruSARS-CoV-2ConceptsLow educational levelCOVID-19Large HIV clinicMajority of PWHCross-sectional telephone surveyHealthcare systemCOVID-19 symptomsHealth impactsHigher COVID-19 case ratesEducational levelMental health impactCOVID-19 case ratesHIV clinicOlder PWHFemale sexRisk factorsPWHMedical careCase ratesNationwide quarantineOlder peopleVulnerable populationsTelephone surveySocioeconomic supportHIV
2020
Longitudinal change in bone mineral density among Chinese individuals with HIV after initiation of antiretroviral therapy
Guo F, Song X, Li Y, Guan W, Pan W, Yu W, Li T, Hsieh E. Longitudinal change in bone mineral density among Chinese individuals with HIV after initiation of antiretroviral therapy. Osteoporosis International 2020, 32: 321-332. PMID: 32803316, PMCID: PMC9509525, DOI: 10.1007/s00198-020-05584-w.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnti-HIV AgentsAsiaBone DensityChinaHIV InfectionsHumansMaleMiddle AgedRetrospective StudiesConceptsTenofovir disoproxil fumarateLong-term clinical managementBone mineral density lossMineral density lossAntiretroviral therapyDisoproxil fumarateClinical managementRisk factorsGreater bone mineral density lossInitiation of TDFDual-energy x-ray absorptiometry testingHIV-specific parametersNon-TDF groupUndetectable viral loadOutpatient HIV clinicRelated risk factorsLarge tertiary hospitalBone mineral densityDensity lossAntiretroviral initiationTDF groupWeek 96HIV clinicWeek 48HIV diagnosisIncidence of hypertension among persons living with HIV in China: a multicenter cohort study
Fan H, Guo F, Hsieh E, Chen WT, Lv W, Han Y, Xie J, Li Y, Song X, Li T. Incidence of hypertension among persons living with HIV in China: a multicenter cohort study. BMC Public Health 2020, 20: 834. PMID: 32487185, PMCID: PMC7268367, DOI: 10.1186/s12889-020-08586-9.Peer-Reviewed Original ResearchConceptsIncidence of hypertensionAntiretroviral therapyChinese PLWHIncident hypertensionInitiation of ARTProspective longitudinal multicenter studyReceipt of ARTCox proportional hazards modelART-naïve patientsDetectable HIV viremiaMulticenter cohort studyCox regression analysisBody mass indexRecent viral loadLongitudinal multicenter studyProportional hazards modelHIV viremiaMedian followZidovudine exposureChronic comorbiditiesHIV careViral suppressionCohort studyConclusionsThe incidenceMass index
2018
Continued Interest and Controversy: Vitamin D in HIV
Hsieh E, Yin MT. Continued Interest and Controversy: Vitamin D in HIV. Current HIV/AIDS Reports 2018, 15: 199-211. PMID: 29713871, PMCID: PMC6003869, DOI: 10.1007/s11904-018-0401-4.BooksMeSH KeywordsAnti-HIV AgentsBone DensityDietary SupplementsFemaleHIVHIV InfectionsHumansMaleRiskTenofovirVitamin DVitamin D DeficiencyConceptsVitD deficiencyVitD supplementationExtra-skeletal outcomesSetting of HIVSubgroup of HIVBone mineral densityRecent FindingsRecent studiesART regimensD deficiencyClinical outcomesPoor outcomeSummaryFurther researchVitamin DChronic diseasesClinical trialsDifferent demographic strataMineral densityClinical roleHIVGreater riskDemographic strataSignificant heterogeneityOutcomesRiskSupplementation
2017
Cardiovascular disease risk among Chinese antiretroviral-naïve adults with advanced HIV disease
Guo F, Hsieh E, Lv W, Han Y, Xie J, Li Y, Song X, Li T. Cardiovascular disease risk among Chinese antiretroviral-naïve adults with advanced HIV disease. BMC Infectious Diseases 2017, 17: 287. PMID: 28427339, PMCID: PMC5397830, DOI: 10.1186/s12879-017-2358-0.Peer-Reviewed Original ResearchConceptsCVD risk factorsFramingham risk scoreRisk factorsRisk scoreCVD riskAtherosclerotic cardiovascular disease risk scoreCommon CVD risk factorsCardiovascular disease risk scoreAdvanced HIV diseaseD risk scoreTreatment-naïve HIVLipid-lowering therapyPrevalence of hypertensionRisk factor treatmentBurden of CVDCardiovascular disease riskTreatment-naïve individualsMulticenter clinical trialAntiretroviral-naïve adultsDisease risk scoreRoutine clinical assessmentHIV providersAdverse eventsBackgroundCardiovascular diseaseHIV disease
2016
Longitudinal increase in vitamin D binding protein levels after initiation of tenofovir/lamivudine/efavirenz among individuals with HIV
Hsieh E, Fraenkel L, Han Y, Xia W, Insogna KL, Yin MT, Zhu T, Cheng X, Li T. Longitudinal increase in vitamin D binding protein levels after initiation of tenofovir/lamivudine/efavirenz among individuals with HIV. AIDS 2016, 30: 1935-1942. PMID: 27124896, PMCID: PMC4949136, DOI: 10.1097/qad.0000000000001131.Peer-Reviewed Original ResearchConceptsTenofovir disoproxil fumarateVitamin DProcollagen type 1 N-terminal propeptideInitiation of TDFTenofovir/lamivudine/efavirenzVitamin D binding protein (VDBP) levelsCollagen type 1 cross-linked C-telopeptideIntact parathyroid hormone levelsCross-linked C-telopeptideIntact parathyroid hormoneParathyroid hormone levelsTotal procollagen type 1 N-terminal propeptideBinding protein levelsProtein levelsMulticenter clinical trialPlasma samplesOngoing multicenter clinical trialsN-terminal propeptideClinical characteristicsParathyroid hormoneBone lossFormation markersDisoproxil fumarateC-telopeptideBone resorptionExploring HIV-related stigma among HIV-infected men who have sex with men in Beijing, China: a correlation study
Li Z, Hsieh E, Morano JP, Sheng Y. Exploring HIV-related stigma among HIV-infected men who have sex with men in Beijing, China: a correlation study. AIDS Care 2016, 28: 1394-1401. PMID: 27137205, PMCID: PMC5069196, DOI: 10.1080/09540121.2016.1179713.Peer-Reviewed Original ResearchConceptsHIV transmissionHIV stigmaStigma scoresPoor self-rated health statusBerger HIV Stigma ScaleSelf-rated health statusHIV-positive MSMIncidence of HIVMultivariable linear regression modelsHuman immunodeficiency virusLevels of HIVHIV Stigma ScaleAdverse health outcomesCross-sectional survey studySocial support networksAntiretroviral therapyHIV statusOpportunistic infectionsImmunodeficiency virusPoor adherenceSocio-demographic characteristicsRisk factorsStudy populationHIVHealth outcomesWhich HIV patients should be screened for osteoporosis
Alvarez E, Belloso WH, Boyd MA, Inkaya AÇ, Hsieh E, Kambugu A, Kaminski G, Martinez E, Stellbrink HJ, Walmsley S, Brown TT, Mallon PW. Which HIV patients should be screened for osteoporosis. Current Opinion In HIV And AIDS 2016, 11: 268-276. PMID: 26895510, DOI: 10.1097/coh.0000000000000269.Peer-Reviewed Original ResearchMeSH KeywordsAbsorptiometry, PhotonHIV InfectionsHumansInternationalityMass ScreeningOsteoporosisRisk AssessmentConceptsBone mineral densityLow bone mineral densityFracture Risk Assessment ToolMeasurement of BMDDual-energy X-ray absorptiometryEnergy X-ray absorptiometryImpact of comorbiditiesManagement of osteoporosisTenofovir disoproxil fumarateX-ray absorptiometryLong-term managementRisk assessment toolHIV physiciansHIV patientsConsensus guidelinesDisoproxil fumaratePhysicians' knowledgeRisk factorsMineral densityCare differsGeneral populationClinical approachPLWHOverall risk estimationSubstance abuse