Daniela Tirziu, PhD
Senior Research ScientistDownloadHi-Res Photo
Cards
Appointments
Cardiovascular Medicine
Primary
Additional Titles
Associate Director of Academic Research, Yale Cardiovascular Research Group
Contact Info
Appointments
Cardiovascular Medicine
Primary
Additional Titles
Associate Director of Academic Research, Yale Cardiovascular Research Group
Contact Info
Appointments
Cardiovascular Medicine
Primary
Additional Titles
Associate Director of Academic Research, Yale Cardiovascular Research Group
Contact Info
About
Titles
Senior Research Scientist
Associate Director of Academic Research, Yale Cardiovascular Research Group
Biography
Dr. Tirziu is a Research Scientist and Associate Director of Academic Research (YCRG) who’s oversaw and served as an instrumental member of numerous, innovative advancements in the cardiovascular medicine, specifically in the fields of atherosclerosis, angiogenesis, myocardial hypertrophy, heart failure and medical devices. Dr. Tirziu’s clinical research is focused on the design, reporting and regulatory documentations for interventional cardiovascular device trials, including First-in-Human, CE Mark, IDE/IND Phase III and IV trials and post marketing studies in the US and worldwide. She has made important contributions to clinical research documents, regulatory documents (clinical trial protocols and study reports) and meta-analyses to guide clinical investigation on several novel cardiovascular devices and cerebral embolic protection devices. Dr. Tirziu's research on the basic science front contributed to the understanding of cellular crosstalk in the heart and unraveled a novel molecular mechanism of endothelium-dependent regulation of myocardial hypertrophy and metabolism.
Appointments
Cardiovascular Medicine
Senior Research ScientistPrimary
Other Departments & Organizations
Education & Training
- Research Associate (postdoctoral training)
- Dartmouth Medical School, Dartmouth-Hitchcock Medical Center (2006)
- PhD
- Romanian Academy of Sciences (2000)
Research
Overview
Dr. Tirziu has made substantial contributions to scientifically sound clinical research documents, regulatory documents (clinical trial protocols and study reports) and meta-analyses to guide clinical investigation on several novel cardiovascular devices and cerebral embolic protection devices during transcatheter heart procedures.
On the basic science front, findings from Dr. Tirziu's laboratory showed that stimulation of angiogenesis in the heart promotes cardiomyocyte growth and myocardial hypertrophy through a nitric oxide (NO)-dependent mechanism involving the degradation of regulator of G protein signaling type 4 (RGS4) and de-repression of the Gβγ/PI3Kγ/Akt/mTORC1 pathway with the up-regulation of miR-182 and miR-146b expression in cardiomyocytes.
Medical Research Interests
Cardiovascular Diseases; Cell Communication; Clinical Trial; Endothelium, Vascular; Endothelium-Dependent Relaxing Factors; Gene Regulatory Networks; Heart Diseases; Heart Failure; MicroRNAs; Publication Characteristics
ORCID
0000-0003-4908-6493
Research at a Glance
Yale Co-Authors
Frequent collaborators of Daniela Tirziu's published research.
Publications Timeline
A big-picture view of Daniela Tirziu's research output by year.
Research Interests
Research topics Daniela Tirziu is interested in exploring.
Alexandra Lansky, MD, FACC, FAHA, FESC
Helen Parise, ScD
Cody Pietras
Samit Shah, MD, PhD, FACC, FSCAI
John K Forrest, MD, FACC, FSCAI
Michael Cleman, MD
54Publications
1,234Citations
Endothelium, Vascular
MicroRNAs
Heart Failure
Cell Communication
Publications
2024
Symptom assessment and angina classification of patients with ischemia and nonobstructive coronary arteries undergoing invasive coronary function testing: from the DISCOVER INOCA multicenter registry
Shah S, Tremmel J, Henry T, Smilowitz N, Prasad M, Kobayashi Y, Henry G, Samady H, Samuels B, Lerman A, Moses J, Zhang Z, Tirziu D, Chamie D, Lansky A. Symptom assessment and angina classification of patients with ischemia and nonobstructive coronary arteries undergoing invasive coronary function testing: from the DISCOVER INOCA multicenter registry. European Heart Journal 2024, 45: ehae666.1617. DOI: 10.1093/eurheartj/ehae666.1617.Peer-Reviewed Original ResearchConceptsCoronary function testingCoronary microvascular dysfunctionInvasive coronary function testingNonobstructive coronary arteriesCanadian Cardiovascular SocietyVasospastic anginaAngina classificationCoronary flow reserveMulticenter registryClassification of patientsChest painCoronary angiographyFemale patientsCMD groupFunction testsAverage coronary flow reserveCoronary arteryPost-procedure diagnosesVasospastic angina groupPatients 4%Coronary vasomotor disordersSymptomatic myocardial bridgingRest symptomsShortness of breathDiagnostic phenotypesLong-term outcomes of ischaemia with no obstructive coronary artery disease (INOCA): a systematic review and meta-analysis
Odanović N, Schwann A, Zhang Z, Kapadia S, Kunnirickal S, Parise H, Tirziu D, Ilic I, Lansky A, Pietras C, Shah S. Long-term outcomes of ischaemia with no obstructive coronary artery disease (INOCA): a systematic review and meta-analysis. Open Heart 2024, 11: e002852. PMID: 39353703, PMCID: PMC11448144, DOI: 10.1136/openhrt-2024-002852.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsCoronary Vasomotor Disorders International Study GroupRate of MACEReduced coronary flow reserveCoronary flow reservePrognosis of patientsVasospastic anginaPatient yearsMyocardial infarctionPrimary outcomeIncidence of primary outcomeLong-term prognosis of patientsSystematic reviewMeta-analysisLong-term prognosisInternational Study GroupAdverse cardiovascular eventsLong-term outcomesImaging stress testsMeta-analysis of studiesRandom-effects modelWeb of ScienceINOCACardiovascular eventsFollow-upVasomotor disordersTCT-677 Evaluating Ischemia With Nonobstructive Coronary Arteries Using Invasive Coronary Function Testing: Insights From the DISCOVER INOCA Multicenter Registry
Shah S, Tremmel J, Smilowitz N, Prasad M, Kobayashi Y, Henry T, Henry G, Samady H, Samuels B, Lerman A, Moses J, Pietras C, Zhang Z, Tirziu D, Parise H, Cristea E, Chamie D, Henrici K, Latif N, Cigarroa N, Lansky A. TCT-677 Evaluating Ischemia With Nonobstructive Coronary Arteries Using Invasive Coronary Function Testing: Insights From the DISCOVER INOCA Multicenter Registry. Journal Of The American College Of Cardiology 2024, 84: b260. DOI: 10.1016/j.jacc.2024.09.802.Peer-Reviewed Original ResearchTCT-674 Diagnosis of Coronary Microvascular Dysfunction With Invasive Coronary Function Testing: Insights From the DISCOVER INOCA Multicenter Registry
Shah S, Samuels B, Tremmel J, Henry T, Smilowitz N, Prasad M, Kobayashi Y, Henry G, Samady H, Lerman A, Moses J, Pietras C, Zhang Z, Tirziu D, Parise H, Cristea E, Chamie D, Henrici K, Latif N, Cigarroa N, Lansky A. TCT-674 Diagnosis of Coronary Microvascular Dysfunction With Invasive Coronary Function Testing: Insights From the DISCOVER INOCA Multicenter Registry. Journal Of The American College Of Cardiology 2024, 84: b258-b259. DOI: 10.1016/j.jacc.2024.09.799.Peer-Reviewed Original ResearchTCT-671 Evaluation of Coronary Tortuosity in Patients With Ischemia and No Coronary Artery Disease: Insights From the DISCOVER INOCA Multicenter Registry
Sohal S, Cristea E, Higney J, Williams O, Ohadi L, Samuels B, Tremmel J, Henry T, Smilowitz N, Prasad M, Kobayashi Y, Henry G, Samady H, Lerman A, Moses J, Pietras C, Zhang Z, Tirziu D, Parise H, Chamie D, Henrici K, Latif N, Lansky A, Shah S. TCT-671 Evaluation of Coronary Tortuosity in Patients With Ischemia and No Coronary Artery Disease: Insights From the DISCOVER INOCA Multicenter Registry. Journal Of The American College Of Cardiology 2024, 84: b258. DOI: 10.1016/j.jacc.2024.09.796.Peer-Reviewed Original ResearchClinical Significance of Diffusion-Weighted Brain MRI Lesions After TAVR Results of a Patient-Level Pooled Analysis
Lansky A, Grubman D, Dwyer M, Zivadinov R, Parise H, Moses J, Shah T, Pietras C, Tirziu D, Gambone L, Leon M, Nazif T, Messé S. Clinical Significance of Diffusion-Weighted Brain MRI Lesions After TAVR Results of a Patient-Level Pooled Analysis. Journal Of The American College Of Cardiology 2024, 84: 712-722. PMID: 39142725, DOI: 10.1016/j.jacc.2024.05.055.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsTranscatheter aortic valve replacementClinical ischemic strokeAcute brain infarctionDW-MRIReceiver operating characteristicIschemic strokeTranscatheter aortic valve replacement resultBrain infarctionPatient-level pooled analysisC-statisticBrain MRI lesionsAcute ischemic brain injuryDiffusion-weighted magnetic resonance imagingAortic valve replacementIndividual lesion volumesCore laboratory analysisIschemic brain injuryPredicting ischemic strokeMagnetic resonance imagingStroke Prevention TrialMRI lesionsValve replacementDW-MRI acquisitionsPatient-level dataPooled analysisDetermining the Cause of Coronary Vasomotor Disorders in Patients With Ischemia and Nonobstructive Coronary Arteries: Design and Rationale of the DISCOVER INOCA Prospective, Multicenter Registry
Shah S, Tremmel J, Henry T, Smilowitz N, Prasad M, Kobayashi Y, Henry G, Samady H, Samuels B, Lerman A, Moses J, Pietras C, Zhang Z, Tirziu D, Parise H, Cristea E, Chamié D, Grubman D, Henrici K, Matmusaeva E, Latif N, Cigarroa N, Lansky A. Determining the Cause of Coronary Vasomotor Disorders in Patients With Ischemia and Nonobstructive Coronary Arteries: Design and Rationale of the DISCOVER INOCA Prospective, Multicenter Registry. Journal Of The Society For Cardiovascular Angiography & Interventions 2024, 3: 102046. PMID: 39132594, PMCID: PMC11308755, DOI: 10.1016/j.jscai.2024.102046.Peer-Reviewed Original ResearchConceptsCoronary function testingObstructive coronary artery diseaseCoronary artery diseaseNonobstructive coronary arteriesLong-term outcomesFollow-upVasomotor disordersEnd pointsComposite of cardiovascular deathCoronary arteryLong-term follow-upCoronary microvascular dysfunctionDiagnostic coronary angiographyCardiovascular adverse eventsAdverse cardiovascular eventsCoronary vasomotor disordersOptical coherence tomographySymptomatic myocardial bridgingShort-term end pointsAtherosclerotic plaque burdenIschemic heart diseaseLong-term end pointsINOCA patientsAcetylcholine provocationPatient-reported outcome measuresSAFETY AND EFFICACY OF ENDOVASCULAR TREATMENT MODALITIES FOR BELOW-THE-KNEE PERIPHERAL ARTERIAL DISEASE: A SYSTEMATIC REVIEW AND NETWORK META-ANALYSIS
Tirziu D, Saleh A, Huang H, Akhlaghi N, Breen T, Parikh S, Rosenfield K, Armstrong E, Geraghty P, Brodmann M, Adams G, Snyder D, Zilinyi R, Altin S, Parise H, Lansky A. SAFETY AND EFFICACY OF ENDOVASCULAR TREATMENT MODALITIES FOR BELOW-THE-KNEE PERIPHERAL ARTERIAL DISEASE: A SYSTEMATIC REVIEW AND NETWORK META-ANALYSIS. Journal Of The American College Of Cardiology 2024, 83: 843. DOI: 10.1016/s0735-1097(24)02833-x.Peer-Reviewed Original Research
2023
Impact of sex on Transcatheter aortic valve replacement outcomes: Results of a single-center study
See C, Wang Y, Yang Y, Tirziu D, Papoutsidakis N, Francese D, Kaple R, Cleman M, Lansky A, Forrest J. Impact of sex on Transcatheter aortic valve replacement outcomes: Results of a single-center study. International Journal Of Cardiology 2023, 398: 131643. PMID: 38065329, DOI: 10.1016/j.ijcard.2023.131643.Peer-Reviewed Original ResearchCitationsConceptsNew-generation valvesTranscatheter Aortic Valve Replacement OutcomesImpact of sexTAVR outcomesArtery diseaseYale-New Haven HospitalSTS mortality scorePeripheral artery diseaseSingle-center studyCoronary artery diseaseKaplan-Meier curvesLog-rank testNew Haven HospitalSex-based disparitiesSignificant differencesCardiovascular comorbiditiesSAPIEN 3Transfemoral accessSAPIEN XTConsecutive patientsCox modelingMortality scoreEvolut RFemale sexEvolut PROPercutaneous Transluminal Angioplasty for Infrapopliteal Chronic Limb-Threatening Ischemia: A Systematic Review and Meta-analysis of Primary Patency and Binary Restenosis Rates.
Snyder D, Zilinyi R, Pruthi S, George S, Tirziu D, Lansky A, Mintz A, Sethi S, Parikh S. Percutaneous Transluminal Angioplasty for Infrapopliteal Chronic Limb-Threatening Ischemia: A Systematic Review and Meta-analysis of Primary Patency and Binary Restenosis Rates. Journal Of Endovascular Therapy 2023, 15266028231212133. PMID: 38008929, DOI: 10.1177/15266028231212133.Peer-Reviewed Original ResearchCitationsAltmetricConceptsChronic limb-threatening ischemiaPercutaneous transluminal angioplastyBinary restenosis ratePrimary patencyPrimary patency rateBinary restenosisTransluminal angioplastyRestenosis rateFuture RCTsPatency ratesTrial dataChronic limb threatening ischemiaLimb threatening ischemiaLimb-threatening ischemiaRandom-effects modelMeta-analysis demonstrateIntermittent claudicationEndovascular therapyCochrane CENTRALPower calculationMeta-analysis estimatesControl armPatencyRCTsSystematic review
Academic Achievements & Community Involvement
honor FAHA
National AwardAmerican Heart AssociationDetails11/11/2013United Stateshonor “Junior Investigator Award”
National AwardThe Society for Vascular Medicine and the North American Vascular Biology OrganizationDetails06/18/2005United Stateshonor “Magna cum laudae”
International AwardRomanian Academy of Sciences, Institute of Cellular Biology and Pathology “Nicolae Simionescu”, RomaniaDetails12/21/2000United Stateshonor “Constantin Velican Award” for research in atherosclerosis and cardiovascular diseases
International AwardRomanian Society for Cell BiologyDetails06/10/1998United States
News
News
- April 01, 2024
Yale Faculty Present Groundbreaking Clinical Research at the 2024 American College of Cardiology Scientific Sessions
- February 01, 2023
2023 American College of Cardiology late-breaking clinical trials and abstracts from Yale
- July 15, 2021
Discoveries & Impact (July 2021)
- April 29, 2021
ACC 2021: Late-Breaking Studies Highlight New Treatment Protocols