2015
Effects of ROS-relative NF-κB signaling on high glucose-induced TLR4 and MCP-1 expression in podocyte injury
Wei M, Li Z, Xiao L, Yang Z. Effects of ROS-relative NF-κB signaling on high glucose-induced TLR4 and MCP-1 expression in podocyte injury. Molecular Immunology 2015, 68: 261-271. PMID: 26364141, DOI: 10.1016/j.molimm.2015.09.002.Peer-Reviewed Original ResearchConceptsToll-like receptor 4Diabetic nephropathyMCP-1 expressionNF-κB inhibitionMCP-1High glucoseReactive oxygen speciesNF-κBSuppression of TLR4NF-κB-dependent signalingChemoattractant protein-1Effects of HGPotential therapeutic targetNF-κB signalingCell viabilityIntracellular reactive oxygen speciesEffects of ROSWestern blot analysisTLR-4Receptor 4Intracellular ROS generationPodocyte injuryPodocyte damageProtective effectCell injury
2014
Crosstalk between protective autophagy and NF-κB signal in high glucose-induced podocytes
Wei M, Li Z, Yang Z. Crosstalk between protective autophagy and NF-κB signal in high glucose-induced podocytes. Molecular And Cellular Biochemistry 2014, 394: 261-273. PMID: 24957786, DOI: 10.1007/s11010-014-2102-7.Peer-Reviewed Original Research
2012
Protective effects of leukemia inhibitory factor against oxidative stress during high glucose-induced apoptosis in podocytes
Xu J, Li Z, Xu P, Yang Z. Protective effects of leukemia inhibitory factor against oxidative stress during high glucose-induced apoptosis in podocytes. Cell Stress And Chaperones 2012, 17: 485-493. PMID: 22270613, PMCID: PMC3368028, DOI: 10.1007/s12192-012-0325-7.Peer-Reviewed Original ResearchConceptsHigh glucose-induced apoptosisLeukemia inhibitory factorGlucose-induced apoptosisOxidative stressInhibitory factorEffects of LIFNicotinamide adenine dinucleotide phosphate (NADPH) oxidaseHigh glucose-induced oxidative stressGlucose-induced oxidative stressElevated levelsAdenine Dinucleotide Phosphate OxidaseHigh glucose-induced cytotoxicityReactive oxygen speciesAnti-inflammatory stimuliLevels of SODDiabetic nephropathyDiphenyltetrazolium bromide assayInterleukin-6 familyCaspase-3 activityTubular regenerationProtective effectPotential therapyPleiotropic glycoproteinFlow cytometryFlow cytometric