Triptolide attenuated injury via inhibiting oxidative stress in Amyloid-Beta25–35-treated differentiated PC12 cells
Xu P, Wang H, Li Z, Yang Z. Triptolide attenuated injury via inhibiting oxidative stress in Amyloid-Beta25–35-treated differentiated PC12 cells. Life Sciences 2015, 145: 19-26. PMID: 26679104, DOI: 10.1016/j.lfs.2015.12.018.Peer-Reviewed Original ResearchConceptsDifferentiated PC12 cellsAβ25-35Alzheimer's diseaseOxidative stressPC12 cellsAβ25-35-induced apoptosisTreatment of ADReactive oxygen speciesPotential neuroprotective effectsEffects of triptolideAβ25-35-induced cytotoxicityDecreased oxidative stressSuperoxide dismutaseProtective functionNeuroprotective effectsImmunohistochemical stainingProtective effectResults of MTTAmyloid betaHerb TripterygiumNervous systemAbnormal depositionCytometry assaysWestern blotTriptolideTriptolide Inhibited Cytotoxicity of Differentiated PC12 Cells Induced by Amyloid-Beta25–35 via the Autophagy Pathway
Xu P, Li Z, Wang H, Zhang X, Yang Z. Triptolide Inhibited Cytotoxicity of Differentiated PC12 Cells Induced by Amyloid-Beta25–35 via the Autophagy Pathway. PLOS ONE 2015, 10: e0142719. PMID: 26554937, PMCID: PMC4640509, DOI: 10.1371/journal.pone.0142719.Peer-Reviewed Original ResearchConceptsDifferentiated PC12 cellsAlzheimer's diseaseAβ25-35Differentiated rat pheochromocytoma cell linePC12 cellsLight chain 3 IITreatment of ADCell apoptosisAutophagy pathwayMicrotubule-associated protein light chain 3 IIAβ25-35-induced cytotoxicityEffect of autophagyCell viabilityElevated cell viabilityLevel of autophagyRat pheochromocytoma cell lineTripterygium wilfordii HookActivation of autophagyNeuroprotective effectsNeurological damagePC12 cell apoptosisInhibited cytotoxicityProtective effectPheochromocytoma cell lineAbnormal deposition