2015
Triptolide attenuated injury via inhibiting oxidative stress in Amyloid-Beta25–35-treated differentiated PC12 cells
Xu P, Wang H, Li Z, Yang Z. Triptolide attenuated injury via inhibiting oxidative stress in Amyloid-Beta25–35-treated differentiated PC12 cells. Life Sciences 2015, 145: 19-26. PMID: 26679104, DOI: 10.1016/j.lfs.2015.12.018.Peer-Reviewed Original ResearchConceptsDifferentiated PC12 cellsAβ25-35Alzheimer's diseaseOxidative stressPC12 cellsAβ25-35-induced apoptosisTreatment of ADReactive oxygen speciesPotential neuroprotective effectsEffects of triptolideAβ25-35-induced cytotoxicityDecreased oxidative stressSuperoxide dismutaseProtective functionNeuroprotective effectsImmunohistochemical stainingProtective effectResults of MTTAmyloid betaHerb TripterygiumNervous systemAbnormal depositionCytometry assaysWestern blotTriptolideTriptolide Inhibited Cytotoxicity of Differentiated PC12 Cells Induced by Amyloid-Beta25–35 via the Autophagy Pathway
Xu P, Li Z, Wang H, Zhang X, Yang Z. Triptolide Inhibited Cytotoxicity of Differentiated PC12 Cells Induced by Amyloid-Beta25–35 via the Autophagy Pathway. PLOS ONE 2015, 10: e0142719. PMID: 26554937, PMCID: PMC4640509, DOI: 10.1371/journal.pone.0142719.Peer-Reviewed Original ResearchConceptsDifferentiated PC12 cellsAlzheimer's diseaseAβ25-35Differentiated rat pheochromocytoma cell linePC12 cellsLight chain 3 IITreatment of ADCell apoptosisAutophagy pathwayMicrotubule-associated protein light chain 3 IIAβ25-35-induced cytotoxicityEffect of autophagyCell viabilityElevated cell viabilityLevel of autophagyRat pheochromocytoma cell lineTripterygium wilfordii HookActivation of autophagyNeuroprotective effectsNeurological damagePC12 cell apoptosisInhibited cytotoxicityProtective effectPheochromocytoma cell lineAbnormal depositionAutophagy Alleviates Melamine-Induced Cell Death in PC12 Cells Via Decreasing ROS Level
Wang H, Gao N, Li Z, Yang Z, Zhang T. Autophagy Alleviates Melamine-Induced Cell Death in PC12 Cells Via Decreasing ROS Level. Molecular Neurobiology 2015, 53: 1718-1729. PMID: 25724280, DOI: 10.1007/s12035-014-9073-2.Peer-Reviewed Original ResearchConceptsPC12 cellsLC3-II/LC3Western blot assaysCell deathReactive oxygen species levelsSuperoxide dismutase activityMDA levelsOxygen species levelsGeneration of ROSATG-7Autophagy markersBlot assaysIncrease of autophagosomesBeclin-1Oxidative stressDismutase activityROS levelsRapamycinExcessive generationExpression levelsCell viabilityOxidative damageAutophagyMalondialdehydeDeath
2013
The role of glycogen synthase kinase-3β in glioma cell apoptosis induced by remifentanil
Xu J, Xu P, Li Z, Xiao L, Yang Z. The role of glycogen synthase kinase-3β in glioma cell apoptosis induced by remifentanil. Cellular & Molecular Biology Letters 2013, 18: 494-506. PMID: 23990403, PMCID: PMC6275801, DOI: 10.2478/s11658-013-0102-3.Peer-Reviewed Original ResearchConceptsGlycogen synthase kinase-3βSynthase kinase-3βGSK-3β activationC6 cell apoptosisCell apoptosisHoechst 33342 stainingGSK-3βKinase-3βSelective small molecule inhibitorsSmall molecule inhibitorsGlioma cell apoptosisFlow cytometryCell deathReceptor signalingMolecule inhibitorsTime-dependent mannerNMDA receptor signalingTumor cell apoptosisTumor cell proliferationCellular levelCell proliferationApoptosisC6 cell deathN-methyl-D-aspartate receptorsCell viabilityNeuroprotective Effect of Leukemia Inhibitory Factor on Antimycin A-Induced Oxidative Injury in Differentiated PC12 Cells
Han Y, Xu J, Li Z, Yang Z. Neuroprotective Effect of Leukemia Inhibitory Factor on Antimycin A-Induced Oxidative Injury in Differentiated PC12 Cells. Journal Of Molecular Neuroscience 2013, 50: 577-585. PMID: 23636893, DOI: 10.1007/s12031-013-0004-x.Peer-Reviewed Original ResearchConceptsLeukemia inhibitory factorOxidative injuryNeuroprotective effectsPC12 cellsInhibitory factorOxidative stressExerts neuroprotective effectsSuperoxide dismutase levelsElevated reactive oxygen species (ROS) levelsPC12 cell viabilityReactive oxygen species levelsHoechst 33342 stainingNeuron injuryDifferentiated PC12 cellsDiphenyltetrazolium bromide assayNeuroendocrine effectsNeurotrophic cytokinesPresence of LIFOxygen species levelsDismutase levelsInjuryAntioxidative effectsBromide assayDimethylthiazol-2Cell viability
2011
Oxidative stress and apoptosis induced by hydroxyapatite nanoparticles in C6 cells
Xu J, Xu P, Li Z, Huang J, Yang Z. Oxidative stress and apoptosis induced by hydroxyapatite nanoparticles in C6 cells. Journal Of Biomedical Materials Research Part A 2011, 100A: 738-745. PMID: 22213249, DOI: 10.1002/jbm.a.33270.Peer-Reviewed Original ResearchConceptsC6 cell apoptosisC6 cellsCell apoptosisReactive oxygen speciesAnti-tumor effectsAnti-glioma treatmentHoechst 33342 stainingTime-dependent mannerC6 cell deathFlow cytometricTotal SODGlioma cellsOxidative stressIntracellular accumulationDimethylthiazol-2Human cancersDiphenyltetrazolium bromideApoptosisCell deathEffect of HACellular levelOxygen speciesCellsCancer