Autophagy ameliorates cognitive impairment through activation of PVT1 and apoptosis in diabetes mice
Li Z, Hao S, Yin H, Gao J, Yang Z. Autophagy ameliorates cognitive impairment through activation of PVT1 and apoptosis in diabetes mice. Behavioural Brain Research 2016, 305: 265-277. PMID: 26971628, DOI: 10.1016/j.bbr.2016.03.023.Peer-Reviewed Original ResearchMeSH KeywordsAdenineAnimalsAntibiotics, AntineoplasticApoptosisAutophagyBeclin-1Body WeightCognition DisordersDiabetes Mellitus, ExperimentalDisease Models, AnimalEatingExploratory BehaviorHippocampusHypoglycemic AgentsLong-Term PotentiationMaleMaze LearningMiceMice, Inbred C57BLMicrotubule-Associated ProteinsPerforant PathwayRNA, Long NoncodingStreptozocinConceptsDiabetic miceLong-term potentiationCognitive impairmentPaired-pulse facilitationAutophagic inhibitionSynaptic plasticityAutophagic suppressionAnxiety-like behaviorCell deathDiabetes micePVT1 expressionHippocampal neuronsPresynaptic functionDiabetesTerm potentiationCell death analysisMiceSpatial learningImpairmentDeath analysisApoptotic cell deathDepotentiationInhibitionDeathPVT1