2015
Triptolide attenuated injury via inhibiting oxidative stress in Amyloid-Beta25–35-treated differentiated PC12 cells
Xu P, Wang H, Li Z, Yang Z. Triptolide attenuated injury via inhibiting oxidative stress in Amyloid-Beta25–35-treated differentiated PC12 cells. Life Sciences 2015, 145: 19-26. PMID: 26679104, DOI: 10.1016/j.lfs.2015.12.018.Peer-Reviewed Original ResearchConceptsDifferentiated PC12 cellsAβ25-35Alzheimer's diseaseOxidative stressPC12 cellsAβ25-35-induced apoptosisTreatment of ADReactive oxygen speciesPotential neuroprotective effectsEffects of triptolideAβ25-35-induced cytotoxicityDecreased oxidative stressSuperoxide dismutaseProtective functionNeuroprotective effectsImmunohistochemical stainingProtective effectResults of MTTAmyloid betaHerb TripterygiumNervous systemAbnormal depositionCytometry assaysWestern blotTriptolideEffects of ROS-relative NF-κB signaling on high glucose-induced TLR4 and MCP-1 expression in podocyte injury
Wei M, Li Z, Xiao L, Yang Z. Effects of ROS-relative NF-κB signaling on high glucose-induced TLR4 and MCP-1 expression in podocyte injury. Molecular Immunology 2015, 68: 261-271. PMID: 26364141, DOI: 10.1016/j.molimm.2015.09.002.Peer-Reviewed Original ResearchConceptsToll-like receptor 4Diabetic nephropathyMCP-1 expressionNF-κB inhibitionMCP-1High glucoseReactive oxygen speciesNF-κBSuppression of TLR4NF-κB-dependent signalingChemoattractant protein-1Effects of HGPotential therapeutic targetNF-κB signalingCell viabilityIntracellular reactive oxygen speciesEffects of ROSWestern blot analysisTLR-4Receptor 4Intracellular ROS generationPodocyte injuryPodocyte damageProtective effectCell injury
2012
Protective effects of leukemia inhibitory factor against oxidative stress during high glucose-induced apoptosis in podocytes
Xu J, Li Z, Xu P, Yang Z. Protective effects of leukemia inhibitory factor against oxidative stress during high glucose-induced apoptosis in podocytes. Cell Stress And Chaperones 2012, 17: 485-493. PMID: 22270613, PMCID: PMC3368028, DOI: 10.1007/s12192-012-0325-7.Peer-Reviewed Original ResearchConceptsHigh glucose-induced apoptosisLeukemia inhibitory factorGlucose-induced apoptosisOxidative stressInhibitory factorEffects of LIFNicotinamide adenine dinucleotide phosphate (NADPH) oxidaseHigh glucose-induced oxidative stressGlucose-induced oxidative stressElevated levelsAdenine Dinucleotide Phosphate OxidaseHigh glucose-induced cytotoxicityReactive oxygen speciesAnti-inflammatory stimuliLevels of SODDiabetic nephropathyDiphenyltetrazolium bromide assayInterleukin-6 familyCaspase-3 activityTubular regenerationProtective effectPotential therapyPleiotropic glycoproteinFlow cytometryFlow cytometric
2011
Oxidative stress and apoptosis induced by hydroxyapatite nanoparticles in C6 cells
Xu J, Xu P, Li Z, Huang J, Yang Z. Oxidative stress and apoptosis induced by hydroxyapatite nanoparticles in C6 cells. Journal Of Biomedical Materials Research Part A 2011, 100A: 738-745. PMID: 22213249, DOI: 10.1002/jbm.a.33270.Peer-Reviewed Original ResearchConceptsC6 cell apoptosisC6 cellsCell apoptosisReactive oxygen speciesAnti-tumor effectsAnti-glioma treatmentHoechst 33342 stainingTime-dependent mannerC6 cell deathFlow cytometricTotal SODGlioma cellsOxidative stressIntracellular accumulationDimethylthiazol-2Human cancersDiphenyltetrazolium bromideApoptosisCell deathEffect of HACellular levelOxygen speciesCellsCancer