2010
ERK1/2-Akt1 crosstalk regulates arteriogenesis in mice and zebrafish
Ren B, Deng Y, Mukhopadhyay A, Lanahan AA, Zhuang ZW, Moodie KL, Mulligan-Kehoe MJ, Byzova TV, Peterson RT, Simons M. ERK1/2-Akt1 crosstalk regulates arteriogenesis in mice and zebrafish. Journal Of Clinical Investigation 2010, 120: 1217-1228. PMID: 20237411, PMCID: PMC2846043, DOI: 10.1172/jci39837.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsArteriesCarrier ProteinsMaleMiceMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3MorphogenesisNeovascularization, PhysiologicNeuropeptidesPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktSignal TransductionVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-2ZebrafishZebrafish Proteins
2006
Arteriogenesis: Noninvasive Quantification with Multi–Detector Row CT Angiography and Three-dimensional Volume Rendering in Rodents
Zhuang ZW, Gao L, Murakami M, Pearlman JD, Sackett TJ, Simons M, de Muinck ED. Arteriogenesis: Noninvasive Quantification with Multi–Detector Row CT Angiography and Three-dimensional Volume Rendering in Rodents. Radiology 2006, 240: 698-707. PMID: 16926325, DOI: 10.1148/radiol.2403050976.Peer-Reviewed Original ResearchConceptsBone marrow-derived mononuclear cellsTotal arterial areaBlood vessel areaCT angiographyNonischemic legsBMC groupArterial areaMarrow-derived mononuclear cellsTotal blood vessel areaMulti-detector row CT angiographyVessel areaRight femoral arteryUnpaired Student's t-testTotal blood vessel volumeBlood vessel densityMulti-detector rowArterial growthBlood vessel volumeStudent's t-testTwo-way analysisRow CT angiographyBMC injectionBarium sulfate suspensionLewis ratsMore arteries