2017
Flavonoid-enriched extract from Hippophae rhamnoides seed reduces high fat diet induced obesity, hypertriglyceridemia, and hepatic triglyceride accumulation in C57BL/6 mice
Yang X, Wang Q, Pang Z, Pan M, Zhang W. Flavonoid-enriched extract from Hippophae rhamnoides seed reduces high fat diet induced obesity, hypertriglyceridemia, and hepatic triglyceride accumulation in C57BL/6 mice. Pharmaceutical Biology 2017, 55: 1207-1214. PMID: 28248545, PMCID: PMC6130443, DOI: 10.1080/13880209.2016.1278454.Peer-Reviewed Original ResearchConceptsHigh-fat dietAdipose tissueC57BL/6 miceFat dietFSH treatmentBody weightMRNA expressionAdipose tissue inflammationMolecular targetsLipid metabolism disordersObese mouse modelHepatic triglyceride accumulationEffect of FSHTNFα mRNA expressionPPARα mRNA expressionRegulation of PPARγBody weight gainPPARγ protein levelsPotential molecular targetsPPARα gene expressionFSH administrationMacrophage infiltrationTissue inflammationCholesterol levelsMetabolism disorders
2015
Myricetin suppresses differentiation of 3 T3-L1 preadipocytes and enhances lipolysis in adipocytes
Wang Q, Wang S, Yang X, You P, Zhang W. Myricetin suppresses differentiation of 3 T3-L1 preadipocytes and enhances lipolysis in adipocytes. Nutrition Research 2015, 35: 317-327. PMID: 25724338, DOI: 10.1016/j.nutres.2014.12.009.Peer-Reviewed Original ResearchMeSH Keywords3T3-L1 CellsAdipocytesAdipogenesisAnimalsAnti-Obesity AgentsCarrier ProteinsCCAAT-Enhancer-Binding Protein-betaCCAAT-Enhancer-Binding ProteinsCell DifferentiationCell SurvivalDown-RegulationFlavonoidsLipaseLipid MetabolismLipolysisLipoprotein LipaseMiceMitogen-Activated Protein KinasesPerilipin-1PhosphoproteinsPhosphorylationPPAR gammaRNA, MessengerSignal TransductionSterol EsteraseTriglyceridesConceptsJun N-terminal kinaseExtracellular signal-regulated kinaseT3-L1 preadipocytesN-terminal kinaseSignal-regulated kinaseTranscription factorsAdipogenesis-related transcription factorsT3-L1T3-L1 adipocytesAdipogenic transcription factorsGlucose transporter 4Phosphorylation of extracellular signal-regulated kinasePhosphorylation levels of extracellular signal-regulated kinaseDifferentiation of preadipocytesAdipocyte protein 2Levels of extracellular signal-regulated kinasePerilipin APeroxisome proliferator-activated receptor gAdipocyte differentiationDose-dependent increaseTransporter 4Adipocyte lipolysisPhosphorylation levelsProtein AMYR treatment