2021
Type I Interferon–Activated STAT4 Regulation of Follicular Helper T Cell–Dependent Cytokine and Immunoglobulin Production in Lupus
Dong X, Antao OQ, Song W, Sanchez GM, Zembrzuski K, Koumpouras F, Lemenze A, Craft J, Weinstein JS. Type I Interferon–Activated STAT4 Regulation of Follicular Helper T Cell–Dependent Cytokine and Immunoglobulin Production in Lupus. Arthritis & Rheumatology 2021, 73: 478-489. PMID: 33512094, PMCID: PMC7914134, DOI: 10.1002/art.41532.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsAntibody FormationAutoantibodiesB-LymphocytesCase-Control StudiesCytokinesDisease Models, AnimalFemaleHumansImmunoglobulinsInterferon Type IInterferon-gammaInterleukinsLupus Erythematosus, SystemicMaleMice, Inbred MRL lprMiddle AgedRNA-SeqSTAT4 Transcription FactorT Follicular Helper CellsConceptsSystemic lupus erythematosusTfh-like cellsTfh cellsIL-21Human lupusDisease activityCytokine productionSTAT4 activationImmunoglobulin productionPathogenic B cell responsesCourse of lupusClinical disease activityT cell secretionLupus-prone miceHealthy control subjectsCourse of diseaseB cell responsesCytokine interleukin-21Potential therapeutic targetType I IFNB cell maturationSLE patientsPathogenic cytokinesLupus erythematosusInterleukin-21
2007
Signaling requirements for translocation of P-Rex1, a key Rac2 exchange factor involved in chemoattractant-stimulated human neutrophil function
Zhao T, Nalbant P, Hoshino M, Dong X, Wu D, Bokoch GM. Signaling requirements for translocation of P-Rex1, a key Rac2 exchange factor involved in chemoattractant-stimulated human neutrophil function. Journal Of Leukocyte Biology 2007, 81: 1127-1136. PMID: 17227822, DOI: 10.1189/jlb.0406251.Peer-Reviewed Original ResearchConceptsProtein kinase AEndogenous P-Rex1P-Rex1Exchange factorBetagamma subunitsCAMP-dependent protein kinase ACell adhesionG protein betagamma subunitsHeterotrimeric G proteinsActivation of PKARac-specific guanineG protein-coupled receptorsProtein betagamma subunitsNeutrophil chemoattractant receptorsProtein-coupled receptorsTyrosine kinase activityDependent RacExtracellular stimuliSpatial regulationKinase AKinase activityF-actinG proteinsImportant regulatorRac2 activation
2005
P-Rex1 Is a Primary Rac2 Guanine Nucleotide Exchange Factor in Mouse Neutrophils
Dong X, Mo Z, Bokoch G, Guo C, Li Z, Wu D. P-Rex1 Is a Primary Rac2 Guanine Nucleotide Exchange Factor in Mouse Neutrophils. Current Biology 2005, 15: 1874-1879. PMID: 16243036, DOI: 10.1016/j.cub.2005.09.014.Peer-Reviewed Original ResearchMeSH KeywordsActinsAnimalsCaseinsCell LineChemotaxisCloning, MolecularEnzyme ActivationGene TargetingGuanine Nucleotide Exchange FactorsHumansImmunoprecipitationMiceMice, KnockoutNeuropeptidesNeutrophilsN-Formylmethionine Leucyl-PhenylalanineProtein TransportRac GTP-Binding ProteinsRac1 GTP-Binding ProteinSuperoxidesConceptsP-Rex1Exchange factorGuanine nucleotide exchange factorsNucleotide exchange factorsRegulation of RacF-actin formationMouse neutrophilsSmall GTPasesRho familyRac activityApparent high affinityRac activatorActin formationRac1 activationRac2 activationCdc42Mouse linesRacRac2RhoAMigration rateRegulationHigh affinityLeukocyte chemoattractantsGTPasesRegulation of PTEN by Rho small GTPases
Li Z, Dong X, Wang Z, Liu W, Deng N, Ding Y, Tang L, Hla T, Zeng R, Li L, Wu D. Regulation of PTEN by Rho small GTPases. Nature Cell Biology 2005, 7: 399-404. PMID: 15793569, DOI: 10.1038/ncb1236.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCdc42 GTP-Binding ProteinChemotaxisDictyosteliumHumansIntracellular Signaling Peptides and ProteinsLeukocytesMiceModels, BiologicalNeutrophilsPhosphoric Monoester HydrolasesProtein Serine-Threonine KinasesProtein TransportPTEN PhosphohydrolaseRhoA GTP-Binding ProteinRho-Associated KinasesTumor Suppressor ProteinsConceptsRegulation of PTENIntracellular localizationEmbryonic kidney cellsSmall GTPaseDownstream effectorsPhospholipid phosphatase activityRho small GTPasesRegulation of chemotaxisKidney cellsHuman embryonic kidney cellsSmall GTPasesRho familyPhosphoinositide substratesKey residuesActive RhoAPhosphatase activityPTENRhoAGTPaseRegulationHuman tumorsCellsDiverse rangeGTPasesCdc42