2008
Epstein‐Barr virus‐induced gene 3 negatively regulates IL‐17, IL‐22 and RORγt
Yang J, Yang M, Htut TM, Ouyang X, Hanidu A, Li X, Sellati R, Jiang H, Zhang S, Li H, Zhao J, Ting AT, Mayer L, Unkeless JC, Labadia ME, Hodge M, Li J, Xiong H. Epstein‐Barr virus‐induced gene 3 negatively regulates IL‐17, IL‐22 and RORγt. European Journal Of Immunology 2008, 38: 1204-1214. PMID: 18412165, PMCID: PMC2989250, DOI: 10.1002/eji.200838145.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCD4-Positive T-LymphocytesCell DifferentiationForkhead Transcription FactorsGene ExpressionGene Expression RegulationInterferon-gammaInterleukin-17InterleukinsListeria monocytogenesListeriosisMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicMinor Histocompatibility AntigensNuclear Receptor Subfamily 1, Group F, Member 3OvalbuminReceptors, Antigen, T-CellReceptors, Retinoic AcidReceptors, Thyroid HormoneSpleenT-LymphocytesT-Lymphocytes, RegulatoryTumor Necrosis Factor-alphaConceptsIL-17IL-22Th17 cellsIL-27Spleen cellsRORgamma tEpstein-Barr virus-induced gene 3IL-17-producing cellsReduced bacterial loadIL-35Protective immunityIL-12p35Th17 conditionsAdaptive immunityEBI3Mouse studiesL. monocytogenesBacterial loadMiceElevated levelsAcute challengeGene 3High levelsP28Immunity
2007
Cooperation between MyD88 and TRIF pathways in TLR synergy via IRF5 activation
Ouyang X, Negishi H, Takeda R, Fujita Y, Taniguchi T, Honda K. Cooperation between MyD88 and TRIF pathways in TLR synergy via IRF5 activation. Biochemical And Biophysical Research Communications 2007, 354: 1045-1051. PMID: 17275788, DOI: 10.1016/j.bbrc.2007.01.090.Peer-Reviewed Original ResearchConceptsToll-like receptorsInterferon regulatory factor 5TLR synergyTRIF pathwayImmune systemMultiple Toll-like receptorsTranscription factor interferon regulatory factor 5Regulatory factor 5Agonist combinationsImmune cellsMyD88 adaptorInnate immunityIRF5 activationTRIF adaptorMyD88Synergistic inductionActivationFactor 5Target genesCross talkCellsAgonistsTRIFPathwayImmunity