2016
Cumulative stress and autonomic dysregulation in a community sample
Lampert R, Tuit K, Hong KI, Donovan T, Lee F, Sinha R. Cumulative stress and autonomic dysregulation in a community sample. Stress 2016, 19: 269-279. PMID: 27112063, PMCID: PMC5072401, DOI: 10.1080/10253890.2016.1174847.Peer-Reviewed Original ResearchConceptsHeart rate variabilityAdverse life eventsChronic stressLife eventsPoor cardiovascular outcomesChronic stressorsCardiac autonomic functionPrimary preventive strategiesAmbulatory ECG monitoringCumulative stress scoreRegression analysisLow-frequency powerNon-invasive measureRecent life eventsCumulative stressCardiovascular outcomesAutonomic functionAutonomic dysregulationPreventive strategiesNN intervalsAutonomic statusHealthy individualsHealth behaviorsECG monitoringRate variability
2009
A Twin Study of Metabolic Syndrome and Autonomic Tone
GEHI AK, LAMPERT R, VELEDAR E, LEE F, GOLDBERG J, JONES L, MURRAH N, ASHRAF A, VACCARINO V. A Twin Study of Metabolic Syndrome and Autonomic Tone. Journal Of Cardiovascular Electrophysiology 2009, 20: 422-428. PMID: 19054251, PMCID: PMC2722434, DOI: 10.1111/j.1540-8167.2008.01363.x.Peer-Reviewed Original ResearchConceptsLower heart rate variabilityHeart rate variabilityAutonomic toneMetS componentsMetabolic syndromeMetS risk factorsHigher cardiovascular mortalityCoronary heart diseaseOne-unit incrementTwin pairsCardiovascular mortalityCardiac deathOverall mortalityAtrial fibrillationPotential confoundersHeart diseaseRisk factorsHeart StudyMiddle-aged male twinsAbnormal modulationRate variabilityMale twinsMetS.MetSSyndrome
2008
Decreased heart rate variability is associated with higher levels of inflammation in middle-aged men
Lampert R, Bremner JD, Su S, Miller A, Lee F, Cheema F, Goldberg J, Vaccarino V. Decreased heart rate variability is associated with higher levels of inflammation in middle-aged men. American Heart Journal 2008, 156: 759.e1-759.e7. PMID: 18926158, PMCID: PMC2587932, DOI: 10.1016/j.ahj.2008.07.009.Peer-Reviewed Original ResearchConceptsC-reactive proteinCoronary artery diseaseBody mass indexHeart rate variabilityTraditional risk factorsInterleukin-6Risk factorsAutonomic functionPhysical activityDevelopment of CADSymptomatic coronary artery diseaseTraditional CAD risk factorsHigh-density lipoprotein cholesterolRate variabilityGraded inverse relationshipCAD risk factorsMiddle-aged menHigh-density lipoproteinAmbulatory electrocardiogram monitoringHigh-frequency powerAutonomic dysfunctionLipoprotein cholesterolArtery diseaseMass indexAutonomic dysregulationDepressive Symptoms and Heart Rate Variability: Evidence for a Shared Genetic Substrate in a Study of Twins
Vaccarino V, Lampert R, Bremner JD, Lee F, Su S, Maisano C, Murrah NV, Jones L, Jawed F, Afzal N, Ashraf A, Goldberg J. Depressive Symptoms and Heart Rate Variability: Evidence for a Shared Genetic Substrate in a Study of Twins. Psychosomatic Medicine 2008, 70: 628-636. PMID: 18606724, PMCID: PMC5884077, DOI: 10.1097/psy.0b013e31817bcc9e.Peer-Reviewed Original Research
2005
Depressed autonomic nervous system function in African Americans and individuals of lower social class: A potential mechanism of race- and class-related disparities in health outcomes
Lampert R, Ickovics J, Horwitz R, Lee F. Depressed autonomic nervous system function in African Americans and individuals of lower social class: A potential mechanism of race- and class-related disparities in health outcomes. American Heart Journal 2005, 150: 153-160. PMID: 16084163, DOI: 10.1016/j.ahj.2004.08.008.Peer-Reviewed Original ResearchEffects of Psychologic Stress on Repolarization and Relationship to Autonomic and Hemodynamic Factors
LAMPERT R, SHUSTERMAN V, BURG MM, LEE FA, EARLEY C, GOLDBERG A, MCPHERSON CA, BATSFORD WP, SOUFER R. Effects of Psychologic Stress on Repolarization and Relationship to Autonomic and Hemodynamic Factors. Journal Of Cardiovascular Electrophysiology 2005, 16: 372-377. PMID: 15828878, DOI: 10.1046/j.1540-8167.2005.40580.x.Peer-Reviewed Original ResearchConceptsT-wave alternansMental stressVentricular arrhythmiasPsychological stressAmbulatory ECG monitoringT-wave amplitudePathophysiologic linkSusceptible patientsSystolic BPRepolarization indicesAlters indicesPsychologic stressRepolarization changesSudden deathPatientsHemodynamic factorsT-wave areaStress protocolECG monitoringArrhythmiasPhysiologic pathwaysRepolarizationMyocardial heterogeneityICDHr
2003
Effects of propranolol on recovery of heart rate variability following acute myocardial infarction and relation to outcome in the Beta-Blocker Heart Attack Trial
Lampert R, Ickovics JR, Viscoli CJ, Horwitz RI, Lee FA. Effects of propranolol on recovery of heart rate variability following acute myocardial infarction and relation to outcome in the Beta-Blocker Heart Attack Trial. The American Journal Of Cardiology 2003, 91: 137-142. PMID: 12521623, DOI: 10.1016/s0002-9149(02)03098-9.Peer-Reviewed Original ResearchConceptsBeta-Blocker Heart Attack TrialAcute myocardial infarctionHeart rate variabilityPlacebo-treated patientsHeart Attack TrialMyocardial infarctionEffect of propranololBeta blockersAttack TrialDepressed heart rate variabilityRate variabilityRecovery of HRVLF/HF ratioPropranolol-treated patientsWeeks of treatmentHF ratioHigh-frequency powerPropranolol therapyPropranolol treatmentSympathetic predominanceAutonomic toneParasympathetic toneSympathovagal balanceImproved outcomesSudden death
2001
Day-to-day reproducibility of mental stress-induced abnormal left ventricular function response in patients with coronary artery disease and its relationship to autonomic activation
Jain D, Joska T, Lee F, Burg M, Lampert R, Zaret B. Day-to-day reproducibility of mental stress-induced abnormal left ventricular function response in patients with coronary artery disease and its relationship to autonomic activation. Journal Of Nuclear Cardiology 2001, 8: 347-355. PMID: 11391305, DOI: 10.1067/mnc.2001.113517.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseSystolic blood pressureLV ejection fractionLV dysfunctionRate-pressure productBlood pressureAnger recallMS taskHeart rate variabilityAutonomic activationLVEF responseArtery diseaseMental stressSympathetic activationHeart rateSymptomatic coronary artery diseaseRate variabilityAbnormal LVEF responseVentricular function responseChronic stable anginaExercise-induced ischemiaLeft ventricular dysfunctionAdverse prognostic signLF/HFCardiac medications