2024
The protective role of GATA6+ pericardial macrophages in pericardial inflammation
Hughes D, Won T, Talor M, Kalinoski H, Jurčová I, Szárszoi O, Stříž I, Čurnová L, Bracamonte-Baran W, Melenovský V, Čiháková D. The protective role of GATA6+ pericardial macrophages in pericardial inflammation. IScience 2024, 27: 110244. PMID: 39040070, PMCID: PMC11260870, DOI: 10.1016/j.isci.2024.110244.Peer-Reviewed Original ResearchMyocardial infarctionMyocardial inflammationPericardial inflammationTrafficking of inflammatory monocytesCoxsackievirus B3-induced myocarditisUpregulation of inflammatory markersPreventing interstitial fibrosisCardiac function post-MIStimulated in vitroFunction post-MIInduced pericarditisInflammatory monocytesInflammatory markersBone marrowInterstitial fibrosisCardiac fibrosisAttenuated traffickingPost-MIInflammationInduced upregulationFibrosisMacrophagesGATA6Pericardial cavityCoxsackievirus B3
2020
Innate Lymphoid Cells Play a Pathogenic Role in Pericarditis
Choi H, Won T, Hou X, Chen G, Bracamonte-Baran W, Talor M, Jurčová I, Szárszoi O, Čurnova L, Stříž I, Hooper J, Melenovský V, Čiháková D. Innate Lymphoid Cells Play a Pathogenic Role in Pericarditis. Cell Reports 2020, 30: 2989-3003.e6. PMID: 32130902, PMCID: PMC7332109, DOI: 10.1016/j.celrep.2020.02.040.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell MovementChemokine CCL11Disease SusceptibilityEosinophilsFemaleFibroblastsGene Expression RegulationHeartHeart Function TestsHumansImmunity, InnateInterleukin-1 Receptor-Like 1 ProteinInterleukin-33Interleukin-5LymphocytesMaleMediastinumMice, Inbred BALB CPericarditisSignal TransductionUp-RegulationConceptsInnate lymphoid cellsEosinophilic pericarditisPathogenic roleMediastinal cavityLymphoid cellsGroup 2 innate lymphoid cellsCardiac fibroblastsDevelopment of pericarditisCardiac inflammationEotaxin-1Healthy controlsPericardial fluidCardiac diseasePericarditisB cellsSerous cavitiesILC2sEosinophilsPatientsMiceHeartCellsCritical roleFibroblastsInflammation