2021
Endothelial Stromal PD-L1 (Programmed Death Ligand 1) Modulates CD8+ T-Cell Infiltration After Heart Transplantation
Bracamonte-Baran W, Gilotra N, Won T, Rodriguez K, Talor M, Oh B, Griffin J, Wittstein I, Sharma K, Skinner J, Johns R, Russell S, Anders R, Zhu Q, Halushka M, Brandacher G, Čiháková D. Endothelial Stromal PD-L1 (Programmed Death Ligand 1) Modulates CD8+ T-Cell Infiltration After Heart Transplantation. Circulation Heart Failure 2021, 14: e007982. PMID: 34555935, PMCID: PMC8550427, DOI: 10.1161/circheartfailure.120.007982.Peer-Reviewed Original ResearchConceptsPD-L1 expressionT cell infiltrationPD-L1Heart transplantationEndothelial cellsHemodynamic parametersPD1/PD-L1 axisCD8 T-cell ratioMultivariate logistic regression analysisPeripheral blood mononuclear cellsMurine model resultsGraft endothelial cellsHeart transplant patientsPD-L1 axisT cell frequenciesT cell ratioHeart transplantation modelSurveillance endomyocardial biopsiesBlood mononuclear cellsHuman heart transplantationLogistic regression analysisGraft expressionLeukocyte compartmentLeukocyte patternModulates CD8
2017
Donor-derived exosomes
Morelli A, Bracamonte-Baran W, Burlingham W. Donor-derived exosomes. Current Opinion In Organ Transplantation 2017, 22: 46-54. PMID: 27898464, PMCID: PMC5407007, DOI: 10.1097/mot.0000000000000372.Peer-Reviewed Original ResearchConceptsDonor MHC moleculesAntigen-presenting cellsSemidirect pathwayLymphoid organsMHC moleculesT cellsPassenger leukocytesDendritic cellsRecipient antigen-presenting cellsDonor antigen-presenting cellsAcute rejection responseDraining lymphoid organsHost dendritic cellsT cell allosensitizationT cell effectorsT helper cellsT cell helpAlloreactive T helper cellsExtracellular vesiclesAcute rejectionAlloantigen exposureDonor exosomesHeart transplantationMaternal microchimerismMaternal antigens