Antigen Presentation by Liver Cells Controls Intrahepatic T Cell Trapping, Whereas Bone Marrow-Derived Cells Preferentially Promote Intrahepatic T Cell Apoptosis
Mehal W, Azzaroli F, Crispe I. Antigen Presentation by Liver Cells Controls Intrahepatic T Cell Trapping, Whereas Bone Marrow-Derived Cells Preferentially Promote Intrahepatic T Cell Apoptosis. The Journal Of Immunology 2001, 167: 667-673. PMID: 11441069, DOI: 10.4049/jimmunol.167.2.667.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigen PresentationApoptosisBone Marrow CellsBone Marrow TransplantationCD8-Positive T-LymphocytesCell MovementCells, CulturedCytotoxicity, ImmunologicLiverLymphocyte ActivationLymphocyte CountLymphocyte DepletionMiceMice, Inbred C57BLMice, TransgenicRadiation ChimeraSpleenStem Cell TransplantationStem CellsConceptsMarrow-derived cellsNon-bone marrow-derived cellsT cellsT cell apoptosisAg presentationLiver injuryBone marrow-derived cellsCell apoptosisSuch liver injuryT cell trappingT cell accumulationBone marrow chimerasTCR transgenic miceT cell populationsT cell deletionAdoptive transferIntrahepatic accumulationLiver damageHepatocyte damageSystemic activationAntigen presentationBone marrowCell accumulationClonal expansionCell deletionInvolvement of CD1 in Peripheral Deletion of T Lymphocytes Is Independent of NK T Cells
Dao T, Exley M, Mehal W, Tahir S, Snapper S, Taniguchi M, Balk S, Crispe I. Involvement of CD1 in Peripheral Deletion of T Lymphocytes Is Independent of NK T Cells. The Journal Of Immunology 2001, 166: 3090-3097. PMID: 11207260, DOI: 10.4049/jimmunol.166.5.3090.Peer-Reviewed Original ResearchConceptsNK T cellsPeripheral T cell deletionT cell deletionT cellsCell deletionCD1-deficient miceBone marrow chimerasExpression of CD1T cell activationMHC-like moleculesNonlymphoid organsLymph nodesPeripheral deletionNormal miceT lymphocytesCell activationMutant mouse linesMouse linesAttenuated accumulationMiceLymphocytesNovel roleCD1Ab resultsLiver