2024
Mechanistic Differences between Torsemide and Furosemide.
Rao V, Cox Z, Ivey-Miranda J, Neville D, Balkcom N, Moreno-Villagomez J, Ramos-Mastache D, Maulion C, Bellumkonda L, Tang W, Collins S, Velazquez E, Mentz R, Wilson F, Turner J, Wilcox C, Ellison D, Fang J, Testani J. Mechanistic Differences between Torsemide and Furosemide. Journal Of The American Society Of Nephrology 2024 PMID: 39196651, DOI: 10.1681/asn.0000000000000481.Peer-Reviewed Original ResearchTorsemide groupDiuretic doseTubular site of actionHigher diuretic dosesDose of furosemideProportion of dosesOral furosemideSite of actionPrescribed doseNeurohormonal activationMechanistic substudyClinical outcomesPharmacodynamic advantagesKidney dysfunctionPharmacodynamic parametersKidney functionRandomized trialsNatriuresisTubular sitesFurosemideTorsemideDoseTRANSFORM-HFPlasma volumeBody weight
2019
Renal Diuretic Delivery is Highly Variable in Hospitalized Decompensated Heart Failure Patients and Associated with Diuretic Resistance
Wycallis E, Stewart B, Ivey-Miranda J, Griffin M, Gomez N, Thomas A, Barnett J, Pattoli M, Struyk G, Fleming J, Shamlian P, Raghavendra P, Rao V, Cox Z, Testani J. Renal Diuretic Delivery is Highly Variable in Hospitalized Decompensated Heart Failure Patients and Associated with Diuretic Resistance. Journal Of Cardiac Failure 2019, 25: s3. DOI: 10.1016/j.cardfail.2019.07.018.Peer-Reviewed Original ResearchLoop diureticsADHF patientsTubular sitesRenal perfusionSite of actionRenal urea handlingDecompensated heart failure patientsYale-New Haven HospitalGood urine outputHospitalized ADHF patientsNT-proBNP levelsHeart failure patientsRoute of administrationNew Haven HospitalUrea handlingDiuretic doseDiuretic resistanceFurosemide equivalentsSolute handlingRenal dysfunctionBlood pressureEjection fractionFailure patientsFractional excretionUrine output