2022
Obstructive Sleep Apnea and Polycystic Ovary Syndrome
Chu Y, Hilbert J, Mohsenin V. Obstructive Sleep Apnea and Polycystic Ovary Syndrome. 2022, 393-409. DOI: 10.1007/978-3-030-92589-5_20.Peer-Reviewed Original ResearchPolycystic ovary syndromeObstructive sleep apneaCardiovascular outcomesOvary syndromeSleep apneaPathogenesis of OSAPrevalence of OSARepetitive upper airway obstructionsUntreated sleep-disordered breathingExcess of androgensUpper airway obstructionImproved cardiovascular outcomesSleep-disordered breathingSleep breathing disordersWeight-matched controlsImproved sleep qualityRates of obesityAirway obstructionNorepinephrine levelsCentral adiposityAtypical symptomsInsulin resistanceTreatment optionsSex hormonesTreatment benefit
2021
Pulmonary Hypertension in Obstructive Sleep Apnea
Mohsenin V. Pulmonary Hypertension in Obstructive Sleep Apnea. 2021, 69-76. DOI: 10.1007/978-3-030-57942-5_6.Peer-Reviewed Original ResearchMean pulmonary artery pressurePulmonary hypertensionChronic obstructive pulmonary diseaseMild pulmonary arterial hypertensionPulmonary artery pressurePulmonary arterial hypertensionThird of patientsChronic lung diseaseObstructive pulmonary diseaseObstructive sleep apneaTreatment of OSADaytime hypoxemiaArterial hypertensionArtery pressureObesity hypoventilationHeart failurePulmonary diseaseSleep apneaLung diseaseHypertensionOSAPatientsDiseaseCurrent definitionHypoxemia
2020
Obstructive Sleep Apnea Increases the Risk of Pulmonary Hypertension Independent of Relevant Risk Factors
Shojaee A, Mohsenin V. Obstructive Sleep Apnea Increases the Risk of Pulmonary Hypertension Independent of Relevant Risk Factors. 2020, a6252-a6252. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a6252.Peer-Reviewed Original Research
2016
Chitinase-3-like protein-1 (YKL-40) as a marker of endothelial dysfunction in obstructive sleep apnea
Jafari B, Mohsenin V. Chitinase-3-like protein-1 (YKL-40) as a marker of endothelial dysfunction in obstructive sleep apnea. Sleep Medicine 2016, 25: 87-92. PMID: 27823723, DOI: 10.1016/j.sleep.2016.08.001.Peer-Reviewed Original ResearchConceptsHypertensive OSAObstructive sleep apneaFlow-mediated vasodilationEndothelial dysfunctionYKL-40Sleep apneaEndothelial-dependent vasodilatory capacityNormotensive OSAChitinase-3-like protein 1Sleep-disordered breathingCharacteristic curve analysisChitinase-3-like proteinHypertension independentVasodilatory capacityCardiovascular morbidityEndothelial functionHypertension statusRisk factorsPrevalent disorderHypertensionNegative correlationDysfunctionPotential biomarkersSignificant negative correlationCurve analysis
2015
Pulmonary Hypertension in Obstructive Sleep Apnea: Is it Clinically Significant? a Critical Analysis of the Association and Pathophysiology
Kholdani C, Fares WH, Mohsenin V. Pulmonary Hypertension in Obstructive Sleep Apnea: Is it Clinically Significant? a Critical Analysis of the Association and Pathophysiology. Pulmonary Circulation 2015, 5: 220-227. PMID: 26064448, PMCID: PMC4449234, DOI: 10.1086/679995.Peer-Reviewed Original ResearchObstructive sleep apneaPulmonary hypertensionPulmonary venous hypertensionVenous hypertensionSleep apneaSetting of OSAPulmonary artery pressurePoor prognostic signHypoxic pulmonary vasoconstrictionMajority of patientsLeft heart dysfunctionAberrant vascular remodelingQuality of lifeResult of apneaVascular cell proliferationArtery pressurePulmonary vasoconstrictionEjection fractionIntermittent hypoxiaPrognostic signHeart dysfunctionLeft heartHigh prevalenceHypertensionVascular remodelingObstructive Sleep Apnea: A New Preventive and Therapeutic Target for Stroke A New Kid on the Block
Mohsenin V. Obstructive Sleep Apnea: A New Preventive and Therapeutic Target for Stroke A New Kid on the Block. The American Journal Of Medicine 2015, 128: 811-816. PMID: 25731137, DOI: 10.1016/j.amjmed.2015.01.037.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaSleep apneaRisk factorsPersistent neurologic impairmentStroke-related outcomesGood neurologic outcomePresence of hypertensionMajority of patientsRisk of strokeTraditional risk factorsCommon comorbid conditionsCause of deathNeurologic outcomeNeurologic recoverySecondary preventionComorbid conditionsNeurologic impairmentAtrial fibrillationDiagnostic workupEarly recognitionStroke rateApneaTherapeutic targetHealthcare providersStroke
2014
Increased Plasma YKL-40/Chitinase-3-Like-Protein-1 Is Associated with Endothelial Dysfunction in Obstructive Sleep Apnea
Jafari B, Elias JA, Mohsenin V. Increased Plasma YKL-40/Chitinase-3-Like-Protein-1 Is Associated with Endothelial Dysfunction in Obstructive Sleep Apnea. PLOS ONE 2014, 9: e98629. PMID: 24878721, PMCID: PMC4039537, DOI: 10.1371/journal.pone.0098629.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaFlow-mediated vasodilationVascular endothelial growth factorYKL-40/chitinaseApnea-hypopnea indexPlasma YKL-40YKL-40Endothelial dysfunctionVasodilatory capacitySleep apneaEndothelial-dependent vasodilatory capacityHypertensive OSANormotensive OSAApparent cardiovascular diseaseRisk of hypertensionProtein 1Events/hrEndothelial growth factorN-OSAVEGF receptor 1Oxygen desaturationSFlt-1Cardiovascular diseaseCommon disorderPositive correlation
2013
Hypertension and endothelial dysfunction in obstructive sleep apnea (OSA) – Is it related to hypoxia?
Mohsenin V, Jafari B. Hypertension and endothelial dysfunction in obstructive sleep apnea (OSA) – Is it related to hypoxia? Sleep Medicine 2013, 14: e210. DOI: 10.1016/j.sleep.2013.11.503.Peer-Reviewed Original ResearchObstructive sleep apneaEndothelial dysfunctionSFlt-1Fms-like tyrosine kinase-1Endothelial-dependent vasodilatory capacitySevere obstructive sleep apneaAngiogenic inhibitorsN-OSACardiovascular adverse outcomesNon-OSA patientsNormotensive OSAS patientsTarget organ damageApnea-hypopnea indexDevelopment of hypertensionArterial oxygen saturationTyrosine kinase-1Significant inverse correlationImpaired FMDIntermittent hypoxemiaSEng concentrationsVasodilatory capacityOSA patientsSympathetic toneIntermittent hypoxiaOrgan damage
2011
Role Of Nitric Oxide-Dependent Vasodilatation And Carbon Monoxide In Developing Hypertension In Obstructive Sleep Apnea (OSA)
Jafari B, Mohsenin V. Role Of Nitric Oxide-Dependent Vasodilatation And Carbon Monoxide In Developing Hypertension In Obstructive Sleep Apnea (OSA). 2011, a2218-a2218. DOI: 10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a2218.Peer-Reviewed Original ResearchObstructive sleep apneaNitric oxide-dependent vasodilatationSleep apneaHypertensionVasodilatationApnea
2004
Is sleep apnea a risk factor for stroke? A critical analysis.
Mohsenin V. Is sleep apnea a risk factor for stroke? A critical analysis. Minerva Medica 2004, 95: 291-305. PMID: 15334043.Peer-Reviewed Original ResearchConceptsModifiable risk factorsSleep apneaRisk factorsSleep-related breathing disordersSerious long-term disabilityDevelopment of strokeObstructive sleep apneaCoronary artery diseaseLong-term disabilityManagement of strokePathogenesis of strokeRecent large epidemiological studiesCause of deathLarge epidemiological studiesArterial hypertensionNeurologic recoveryAcute strokeArtery diseaseHemodynamic changesSignificant morbidityBreathing disordersProspective studyCardiac diseaseTherapeutic approachesApnea
2001
Gender Differences in the Expression of Sleep-Disordered Breathing Role of Upper Airway Dimensions
Mohsenin V. Gender Differences in the Expression of Sleep-Disordered Breathing Role of Upper Airway Dimensions. CHEST Journal 2001, 120: 1442-1447. PMID: 11713117, DOI: 10.1378/chest.120.5.1442.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaSleep-disordered breathingUpper airway sizeUpper airway dimensionsSleep apneaAirway sizeMale patientsFemale patientsAirway dimensionsUpper airwayEvaluation of SDBPrevalence of OSAPharyngeal sizeGreater total body fatMild obstructive sleep apneaUpper airway resistance syndromeSevere obstructive sleep apneaPharyngeal muscle toneUpper airway patencyEffect of obesityExcessive daytime sleepinessSimilar clinical presentationUpper airway narrowingDifferent pathogenetic mechanismsMajor risk factor
1999
Quality of Life in Patients with Obstructive Sleep Apnea Effect of Nasal Continuous Positive Airway Pressure—A Prospective Study
D’Ambrosio C, Bowman T, Mohsenin V. Quality of Life in Patients with Obstructive Sleep Apnea Effect of Nasal Continuous Positive Airway Pressure—A Prospective Study. CHEST Journal 1999, 115: 123-129. PMID: 9925072, DOI: 10.1378/chest.115.1.123.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaQuality of lifeMental healthMedical Outcomes Study Short Form-36 questionnaireNasal continuous positive airway pressure treatmentEffect of OSAContinuous positive airway pressure (CPAP) treatmentNasal continuous positive airway pressureDiagnosis of OSASocial functioningPositive airway pressure treatmentContinuous positive airway pressureShort Form-36 questionnaireEffect of nCPAPPositive airway pressureRespiratory disturbance indexSleep-disordered breathingBody mass indexEvents/hGender-matched populationCase series analysisSeverity of diseaseMagnitude of improvementNCPAP levelNCPAP therapy